Relationship between expression of ras p21 oncoprotein and mutation status of the K-ras gene in sporadic colorectal cancer patients in tunisia

Applied Immunohistochemistry and Molecular Morphology

Volumn 20, Issue 2, 2012, Pages 146-152

  Sammoud, Souraya ^a   Khiari, Meriem ^a   Semeh, Amara ^a   Amine, Lounis ^a   Ines, Chaar ^a   Amira, Arfaoui ^a   Lilia, Kriaa ^a   Taher, Khalfallah ^b   Sabeh, Mzabi ^b   Saadia, Bouraoui ^a,b  

^a UNIVERSITY OF TUNIS   (Tunisia)

^b MONGI SLIM HOSPITAL   (Tunisia)

Author keywords

colorectal cancer; immunohistochemical; K ras mutations; ras p21 expression

Indexed keywords

K RAS PROTEIN; PROTEIN P21;

ADULT; ARTICLE; CANCER PATIENT; CODON; COLORECTAL CANCER; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PATHOLOGY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; TUNISIA;

ADULT; AGED; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; ONCOGENE PROTEIN P21(RAS); POINT MUTATION; RETROSPECTIVE STUDIES; TUNISIA;

EID: 84857913195     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e3182240de1     Document Type: Article

References (32)

1. Fearon ER, Vogelstein B. A genetic model for colorectal tumor-igenesis. Cell. 1990;61:759-767.
2. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319: 525-532.
3. Egan SE, Weinberg RA. The pathway to signal achievement. Nature. 1993;365:781-783. (Pubitemid 23341020)
4. McDermott U, Longley DB, Johnston PG. Molecular and biochemical markers in colorectal cancer. Ann Oncol. 2002;13(suppl 4): 235-245. (Pubitemid 35363779)
5. Edkins S, O'Meara S, Parker A, et al. Recurrent KRAS codon 146 mutations in human colorectal cancer. Cancer Biol Ther. 2006;5: 928-932.
6. Russo A, Bazan V, Agnese V, et al. Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies. Ann Oncol. 2005;16(suppl 4): iv44-iv49. (Pubitemid 43084945)
7. Andreyev HJ, Norman AR, Cunningham D, et al. Kirsten ras mutations in patients with colorectal cancer: the "RASCAL II" study. Br J Cancer. 2001;85:692-696. (Pubitemid 32929467)
8. Urosevic N, Krtolica K, Skaro-Milic A, et al. Prevalence of G-to-C tranversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia. Int J Cancer. 1993;54:249-254. (Pubitemid 23154890)
9. Bos JL. The ras gene family and human carcinogenesis. Mutat Res. 1988;195:255-271.
10. Capella G, Cronauer-Mitra S, Pienado MA, et al. Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect. 1991;93:125-131.
11. Akkiprik M, Celikel CA, Dusunceli F, et al. Relationship between overexpression of ras p21 oncoprotein and K-ras codon 12 and 13 mutations in Turkish colorectal cancer patients. Turk J Gastro-enterol. 2008;19:22-27. (Pubitemid 351677154)
12. Viguier J, Bourlier P, Karsenti D, et al. Colon cancer. Medico-Surgical encyclopedia. 2003;18. 9-068-6-10.
13. Françoise P, Laurent M, Caroline C, et al. Genetic pathways in colorectal cancer: interest for the pathologist. Annales de pathologie. 2002;22:277-288.
14. Olschwang S. Cell cycle, proliferation and colon cancer. Annals of Pathology. 1997;S14-S15.
15. Bazan V, Migliavacca M, Zanna I, et al. Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol. 2002;13:1438-1446.
16. Hanski C. Is mucinous carcinoma of the colorectum a distinct genetic entity? Br J Cancer. 1995;72:1350-1356. (Pubitemid 26002642)
17. Ikeda S, Shimizu Y, Fujimori M, et al. Immunohistochemical and mutational analyses of beta-catenin, Ki-ras, and p53 in two subtypes of colorectal mucinous carcinoma. Clin Cancer Res. 2003;9: 5660-5665. (Pubitemid 37499488)
18. Chiang JM, Wu Chou YH, Ma SC, et al. Influence of age on adenomatous polyposis coli and p53 mutation frequency in sporadic colorectal cancerFrarity of co-occurrence of mutations in APC, K-ras, and p53 genes. Virchows Arch. 2004;445:465-471.
19. Sundstrom M, Edlund K, Lindell M, et al. KRAS analysis in colorectal carcinoma: analytical aspects of pyrosequencing and allele-specific PCR in clinical practice. BMC Cancer. 2010;10:660.
20. Wojcik P, Kulig J, Okor K, et al. KRAS mutation profile in colorectal carcinoma and novel mutation-internal tandem duplication in KRAS. Pol J Pathol. 2008;59:93-96. (Pubitemid 352029608)
21. Servomaa K, Kiuru A, Kosma VM, et al. p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women. Mol Pathol. 2000;53:24-30. (Pubitemid 30075071)
22. Morin M, Kelly M, Barrett N, et al. Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance. Gut. 1994;35:1627-1631. (Pubitemid 24339267)
23. Sameer AS, Chwdhri NA, Abdullah S, et al. Mutation pattern of K-ras gene of colorectal cancer patients in Kashmir: a report. Indian J Cancer. 2009;46:219-225.
24. Scheffzek K, Ahmadian M, Wittinghofer A. GTPase-activating proteins: helping hands to complement an active site. Trends Biochem Sci. 1998;23:257-262. (Pubitemid 28343370)
25. Slattery ML, Curtin K, Anderson K, et al. Associations between dietary intake and K-ras mutations in colon tumors: a population based study. Cancer Res. 2000;60:6935-6941. (Pubitemid 32059166)
26. Benhattar J, Losi L, Chaubert P, et al. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology. 1993;104: 1044-1048. (Pubitemid 23090756)
27. Cerottini JP, Caplin S, Saraga E, et al. The type of K-ras mutation determines prognosis in colorectal cancer. Am J Surg. 1998; 175:198-202. (Pubitemid 28173710)
28. Samowitz WS, Curtin K, Schaffer D, et al. Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol Biomarkers Prev. 2000; 9:1193-1197.
29. Al-Mulla F, Going JJ, Sowden ET, et al. Heterogeneity of mutant versus wild-type in primary and metastatic colorectal carcinomas, and association of codon 12 valine with early mortality. J Pathol. 1998;185:130-138. (Pubitemid 28270924)
30. Delattre O, Olschwang S, Law DJ, et al. Multiple genetic alterations in distal and proximal colorectal cancer. Lancet. 1989;2:353-356. (Pubitemid 19189066)
31. Oudejans JJ, Slebos RJ, Zoetmulder FA, et al. Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver. Int J Cancer. 1991;49: 875-879.
32. McMicheal AJ, Potter JD. Do intrinsic sex differences in lower alimentary tract physiology influence the sex-specific risks of bowel cancer and other biliary and intestinal diseases? Am J Epidemiol. 1983;118:620-627. (Pubitemid 14230038)