Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype

Annals of Oncology

Volumn 13, Issue 9, 2002, Pages 1438-1446

  Salerno, S ^a   Bazan, V ^b   Tomasino, R M ^c   Migliavacca, M ^b   Labianca, R ^d   Zanna, I ^b   Gebbia, N ^a   Tubiolo, C ^b   Grassi, N ^e   Russo, A ^b   Latteri, M A ^e   La Farina, M ^f   Albanese, I ^f   Dardanoni, G ^g  

^a Section of Medical Oncology   (Italy)

^b Section of Molecular Oncology   (Italy)

^c School of Medicine   (Italy)

^d Ospedali Riuniti Bergamo   (Italy)

^e Reg Ref Ctr for the Biomolec Charact of Neoplasms and Genetic Screening of Hered Tumors   (Italy)

^f UNIVERSITY OF PALERMO   (Italy)

^g Sicilian Regional Centre of Pharmacovigilance   (Italy)

Author keywords

Colorectal carcinoma; DNA ploidy; K ras mutations; Prognosis

Indexed keywords

ADENINE; GUANINE; ONCOPROTEIN;

ARTICLE; CANCER MORTALITY; CANCER RECURRENCE; CANCER STAGING; CARCINOGENESIS; CELL CYCLE S PHASE; CODON; COLORECTAL CANCER; COLORECTAL SURGERY; CONTROLLED STUDY; DISEASE ASSOCIATION; FOLLOW UP; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MULTIVARIATE ANALYSIS; ONCOGENE K RAS; OUTCOMES RESEARCH; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RISK ASSESSMENT; SINGLE STRAND CONFORMATION POLYMORPHISM; TISSUE DIFFERENTIATION; TISSUE TYPES;

ADENOCARCINOMA; ADULT; AGED; ANALYSIS OF VARIANCE; BIOPSY, NEEDLE; CODON; COLORECTAL NEOPLASMS; CULTURE TECHNIQUES; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; GENES, RAS; GENETIC MARKERS; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTATION; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; PROBABILITY; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 0036739336     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/mdf226     Document Type: Article

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