Inactivation of O6-methyguanine-DNA methyltransferase by promoter hypermethylation: Association of epithelial ovarian carcinogenesis in specific histological types

Journal of Obstetrics and Gynaecology Research

Volumn 37, Issue 7, 2011, Pages 851-860

  Roh, Hyun Jin ^a   Suh, Dong Soo ^b,c   Choi, Kyung Un ^b,c   Yoo, Hang Jo ^a   Joo, Won Deok ^a   Yoon, Man Soo ^b,c  

^a University of Ulsan College of Medicine   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Pusan National University   (South Korea)

Author keywords

DNA hypermethylation; microsatellite instability; negative GMTexpression; O6 methyguanine DNA methyltransferase; ovarian cancer

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TUMOR PROTEIN;

ADULT; ARTICLE; CANCER STAGING; CANCER TISSUE; CLEAR CELL CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CPG ISLAND; DNA METHYLATION; EPITHELIUM TUMOR; FEMALE; FLUORESCENCE ANALYSIS; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; MUCINOUS CARCINOMA; OVARY CANCER; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; ADOLESCENT; AGED; DOWN REGULATION; DRUG ANTAGONISM; GENETICS; METABOLISM; MIDDLE AGED; NEOPLASM; OVARY TUMOR; PATHOLOGY; PROMOTER REGION;

ADOLESCENT; ADULT; AGED; DNA METHYLATION; DOWN-REGULATION; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASMS, GLANDULAR AND EPITHELIAL; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OVARIAN NEOPLASMS; PROMOTER REGIONS, GENETIC; YOUNG ADULT;

EID: 80052699883     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/j.1447-0756.2010.01452.x     Document Type: Article

References (32)

1. NIH consensus conference. Ovarian cancer. Screening, treat-ment, and follow-up. NIH consensus development panel on ovarian cancer. JAMA 1995; 273: 491-497.
2. Engel J, Eckel R, Schubert-Fritschle G et al. Moderate progress for ovarian cancer in the last 20 years: prolongation of sur-vival, but no improvement in the cure rate. Eur J Cancer 2002; 38: 2435-2445. (Pubitemid 35387497)
3. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hyperm-ethylation profile of human cancer. Cancer Res 2001; 61: 3225-3229. (Pubitemid 32695003)
4. Yang HJ, Liu VW, Wang Y, Tsang PC, Ngan HY. Differential DNA methylation profiles in gynecological cancers and cor-relation with clinico-pathological data. BMC Cancer 2006; 6: 212.
5. Akahira J, Sugihashi Y, Ito K, Niikura H, Okamura K, Yae-gashi N. Promoter methylation status and expression of TMS1 gene in human epithelial ovarian cancer. Cancer Sci 2004; 95: 40-43. (Pubitemid 38208405)
6. Furlan D, Carnevali I, Marcomini B et al. The high frequency of de novo promoter methylation in synchronous primary endometrial and ovarian carcinomas. Clin Cancer Res 2006; 12: 3329-3336.
7. Hengstler JG, Tanner B, Moller L, Meinert R, Kaina B. Activity of O(6)-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer. Int J Cancer 1999; 84: 388-395. (Pubitemid 29337125)
8. Katsaros D, Cho W, Singal R et al. Methylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancer. Gynecol Oncol 2004; 94: 685-692. (Pubitemid 39194461)
9. Makarla PB, Saboorian MH, Ashfaq R et al. Promoter hyper-methylation profile of ovarian epithelial neoplasms. Clin Cancer Res 2005; 11: 5365-5369. (Pubitemid 41060809)
10. Virmani AK, Muller C, Rathi A, Zoechbauer-Mueller S, Mathis M, Gazdar AF. Aberrant methylation during cervical carcinogenesis. Clin Cancer Res 2001; 7: 584-589. (Pubitemid 32707982)
11. Yang HJ, Liu VW, Wang Y, et al. Detectionofhypermethylated genes in tumor and plasma of cervical cancer patients. Gynecol Oncol 2004; 93: 435-440. (Pubitemid 38507614)
12. Liu L, Gerson SL. Targeted modulation of MGMT: clinical implications. Clin Cancer Res 2006; 12: 328-331. (Pubitemid 43166117)
13. Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS, Futscher BW. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol 1997; 17: 5612-5619. (Pubitemid 27357657)
14. Al-Kuraya K, Narayanappa R, Siraj AK et al. High frequency and strong prognostic relevance of O6-methylguanine DNA methyltransferase silencing in diffuse large B-cell lymphomas from the Middle East. Hum Pathol 2006; 37: 742-748. (Pubitemid 43956546)
15. Bae SI, Lee HS, Kim SH, Kim WH. Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers. Br J Cancer 2002; 86: 1888-1892.
16. Brell M, Tortosa A, Verger E et al. Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. Clin Cancer Res 2005; 11: 5167-5174. (Pubitemid 41003702)
17. Chu LC, Eberhart CG, Grossman SA, Herman JG. Epigenetic silencing of multiple genes in primary CNS lymphoma. Int J Cancer 2006; 119: 2487-2491. (Pubitemid 44546976)
18. Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999; 59: 793-797. (Pubitemid 29086728)
19. Fox EJ, Leahy DT, Geraghty R et al. Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer. J Mol Diagn 2006; 8: 68-75. (Pubitemid 43257436)
20. Hegi ME, Diserens AC, Gorlia T et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005; 352: 997-1003. (Pubitemid 40349502)
21. Lin Z, Gao M, Zhang X et al. The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions. J Cancer Res Clin Oncol 2005; 131: 364-370. (Pubitemid 40674621)
22. Boland CR, Thibodeau SN, Hamilton SR et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58: 5248-5257. (Pubitemid 28521189)
23. Dellas A, Puhl A, Schraml P et al. Molecular and clinicopatho-logical analysis of ovarian carcinomas with and without microsatellite instability. Anticancer Res 2004; 24: 361-369. (Pubitemid 38279733)
24. Haas CJ, Diebold J, Hirschmann A, Rohrbach H, Schmid S, Lohrs U. Microsatellite analysis in serous tumors of the ovary. Int J Gynecol Pathol 1999; 18: 158-162. (Pubitemid 29153283)
25. Sood AK, Holmes R, Hendrix MJ, Buller RE. Application of the National Cancer Institute international criteria for deter-mination of microsatellite instability in ovarian cancer. Cancer Res 2001; 61: 4371-4374. (Pubitemid 32685761)
26. Tavassoéli FA, Devilee P. Pathology and Genetics of Tumors of the Breast and Female Genital Organs. World Health Organization Classification of Tumors. Lyon: IARC Press, 2003.
27. Frederick LG, David LP, Irvin DF et al. AJCC Cancer Staging Manual, 6th edn. New York: Springer Verlag, 2002.
28. Silverberg SG. Histopathologic grading of ovarian carcinoma: a review and proposal. Int J Gynecol Pathol 2000; 19: 7-15. (Pubitemid 30010638)
29. Cai KQ, Albarracin C, Rosen D et al. Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma. Hum Pathol 2004; 35: 552-559. (Pubitemid 38656938)
30. Liu J, Albarracin CT, Chang KH et al. Microsatellite instability and expression of hMLH1 and hMSH2 proteins in ovarian endometrioid cancer. Mod Pathol 2004; 17: 75-80. (Pubitemid 41656455)
31. Gryfe R, Kim H, Hsieh ET et al. Tumor microsatellite instabil-ity and clinical outcome in young patients with colorectal cancer. N Engl J Med 2000; 342: 69-77. (Pubitemid 30036597)
32. Chen SS, Citron M, Spiegel G, Yarosh D. O6-methylguanine-DNA methyltransferase in ovarian malignancy and its corre-lation with postoperative response to chemotherapy. Gynecol Oncol 1994; 52: 172-174.