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Volumn 7, Issue 5, 2012, Pages

KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; BRAF PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; RAS PROTEIN;

EID: 84860617477     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036653     Document Type: Article
Times cited : (69)

References (38)
  • 1
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, et al. (2004) Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer. N Engl J Med 351: 337-345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5
  • 2
    • 13744251436 scopus 로고    scopus 로고
    • Systemic Therapy for Colorectal Cancer
    • Meyerhardt JA, Mayer RJ, (2005) Systemic Therapy for Colorectal Cancer. N Engl J Med 352: 476-487.
    • (2005) N Engl J Med , vol.352 , pp. 476-487
    • Meyerhardt, J.A.1    Mayer, R.J.2
  • 3
    • 34147103678 scopus 로고    scopus 로고
    • Open-Label Phase III Trial of Panitumumab Plus Best Supportive Care Compared With Best Supportive Care Alone in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer
    • Van Cutsem E, Peeters M, Siena S, Humblet Y, et al. (2007) Open-Label Phase III Trial of Panitumumab Plus Best Supportive Care Compared With Best Supportive Care Alone in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer. Journal of Clinical Oncology 25: 1658-1664.
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 1658-1664
    • van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4
  • 4
    • 77951936254 scopus 로고    scopus 로고
    • Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review
    • Tol J, Punt C, (2010) Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review. Clin Ther 32: 437-53.
    • (2010) Clin Ther , vol.32 , pp. 437-453
    • Tol, J.1    Punt, C.2
  • 5
    • 3242686833 scopus 로고    scopus 로고
    • The price tag on progress-chemotherapy for colorectal cancer
    • Schrag D, (2004) The price tag on progress-chemotherapy for colorectal cancer. N Engl J Med 351: 317-319.
    • (2004) N Engl J Med , vol.351 , pp. 317-319
    • Schrag, D.1
  • 7
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic Activation of the RAS/RAF Signaling Pathway Impairs the Response of Metastatic Colorectal Cancers to Anti-Epidermal Growth Factor Receptor Antibody Therapies
    • Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, et al. (2007) Oncogenic Activation of the RAS/RAF Signaling Pathway Impairs the Response of Metastatic Colorectal Cancers to Anti-Epidermal Growth Factor Receptor Antibody Therapies. Cancer Research 67: 2643-2648.
    • (2007) Cancer Research , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5
  • 8
    • 44449090596 scopus 로고    scopus 로고
    • Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone
    • Freeman D, Juan T, Reiner M, Hecht JR, Meropol, et al. (2008) Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone. Clin Colorectal Cancer 7: 184-190.
    • (2008) Clin Colorectal Cancer , vol.7 , pp. 184-190
    • Freeman, D.1    Juan, T.2    Reiner, M.3    Hecht, J.R.4    Meropol5
  • 9
    • 84860632995 scopus 로고    scopus 로고
    • Class Labeling Changes to Anti-EGFR Monoclonal Antibodies, Cetuximab (Erbitux) and Panitumumab (Vectibix): KRAS Mutations
    • Food and Drug Administration, Accessed 07 October2011
    • Food and Drug Administration (2011) Class Labeling Changes to Anti-EGFR Monoclonal Antibodies, Cetuximab (Erbitux) and Panitumumab (Vectibix): KRAS Mutations. http://www.fda.gov/AboutFDA/CentersOffices/CDER/ucm172905.htm Accessed 07 October2011.
    • (2011)
  • 11
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
    • Moroni M, Veronese S, Benvenuti S, Marrapese G, Sartore-Bianchi A, et al. (2005) Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. The Lancet Oncology 6: 279-286.
    • (2005) The Lancet Oncology , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3    Marrapese, G.4    Sartore-Bianchi, A.5
  • 12
    • 63949084084 scopus 로고    scopus 로고
    • Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant
    • Molinari F, Martin V, Saletti P, Saletti P, De Dosso S, et al. (2009) Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant. Br J Cancer 100: 1087-1094.
    • (2009) Br J Cancer , vol.100 , pp. 1087-1094
    • Molinari, F.1    Martin, V.2    Saletti, P.3    Saletti, P.4    de Dosso, S.5
  • 13
    • 35348908314 scopus 로고    scopus 로고
    • PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
    • Frattini M, Saletti P, Romagnani E, Martin V, Molinari F, et al. (2007) PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 97: 1139-1145.
    • (2007) Br J Cancer , vol.97 , pp. 1139-1145
    • Frattini, M.1    Saletti, P.2    Romagnani, E.3    Martin, V.4    Molinari, F.5
  • 14
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies
    • Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, et al. (2009) PIK3CA Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies. Cancer Research 69: 1851-1857.
    • (2009) Cancer Research , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3    Veronese, S.4    Nichelatti, M.5
  • 15
    • 79955928991 scopus 로고    scopus 로고
    • Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients
    • Shen H, Yuan Y, Hu H, Zhong X, Ye XX, et al. (2011) Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients. World J Gastroenterol 17: 809-816.
    • (2011) World J Gastroenterol , vol.17 , pp. 809-816
    • Shen, H.1    Yuan, Y.2    Hu, H.3    Zhong, X.4    Ye, X.X.5
  • 16
    • 80755132294 scopus 로고    scopus 로고
    • Mutations in BRAF correlate with poor survival of colorectal cancers in Chinese population
    • Liou JM, Wu MS, Shun CT, Chiu HM, Chen MJ, et al. (2011) Mutations in BRAF correlate with poor survival of colorectal cancers in Chinese population. Int J Colorectal Dis 6: 1387-1395.
    • (2011) Int J Colorectal Dis , vol.6 , pp. 1387-1395
    • Liou, J.M.1    Wu, M.S.2    Shun, C.T.3    Chiu, H.M.4    Chen, M.J.5
  • 17
    • 79954490871 scopus 로고    scopus 로고
    • KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer
    • Li HT, Lu YY, An YX, Wang X, Zhao QC, (2011) KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer. Oncol Rep 25: 1691-1697.
    • (2011) Oncol Rep , vol.25 , pp. 1691-1697
    • Li, H.T.1    Lu, Y.Y.2    An, Y.X.3    Wang, X.4    Zhao, Q.C.5
  • 19
    • 75549090214 scopus 로고    scopus 로고
    • Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    • Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A, (2009) Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol Res Pract 205: 858-62.
    • (2009) Pathol Res Pract , vol.205 , pp. 858-862
    • Neumann, J.1    Zeindl-Eberhart, E.2    Kirchner, T.3    Jung, A.4
  • 21
    • 77952892341 scopus 로고    scopus 로고
    • Integrated molecular dissection of the epidermal growth factor receptor (EFGR) oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer
    • Sartore-Bianchi A, Bencardino K, Di Nicolantonio F, Pozzi F, Funaioli C, et al. (2010) Integrated molecular dissection of the epidermal growth factor receptor (EFGR) oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer. Targeted Oncology 5: 19-28.
    • (2010) Targeted Oncology , vol.5 , pp. 19-28
    • Sartore-Bianchi, A.1    Bencardino, K.2    Di Nicolantonio, F.3    Pozzi, F.4    Funaioli, C.5
  • 22
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, et al. (2010) Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. The Lancet Oncology 11: 753-762.
    • (2010) The Lancet Oncology , vol.11 , pp. 753-762
    • de Roock, W.1    Claes, B.2    Bernasconi, D.3    de Schutter, J.4    Biesmans, B.5
  • 23
    • 78649988884 scopus 로고    scopus 로고
    • Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer
    • doi:10.1038/sj.bjc.6606008
    • Di Fiore F, Sesboue R, Michel P, Sabourin JC, Frebourg T, (2010) Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer. Br J Cancer doi:10.1038/sj.bjc.6606008.
    • (2010) Br J Cancer
    • Di Fiore, F.1    Sesboue, R.2    Michel, P.3    Sabourin, J.C.4    Frebourg, T.5
  • 24
    • 77954215850 scopus 로고    scopus 로고
    • Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
    • Tol J, Dijkstra JR, Klomp M, Teerenstra S, Dommerholt M, et al. (2010) Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. European Journal of Cancer 46: 1997-2009.
    • (2010) European Journal of Cancer , vol.46 , pp. 1997-2009
    • Tol, J.1    Dijkstra, J.R.2    Klomp, M.3    Teerenstra, S.4    Dommerholt, M.5
  • 25
    • 32044455746 scopus 로고    scopus 로고
    • BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
    • Li W, Kawakami K, Ruszkiewicz A, Bennett G, Moore J, et al. (2006) BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. Mol Cancer 5: 2.
    • (2006) Mol Cancer , vol.5 , pp. 2
    • Li, W.1    Kawakami, K.2    Ruszkiewicz, A.3    Bennett, G.4    Moore, J.5
  • 28
    • 77949435827 scopus 로고    scopus 로고
    • Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer
    • Bardelli A, Siena S, (2010) Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer. Journal of Clinical Oncology 28: 1254-1261.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 29
    • 79954490871 scopus 로고    scopus 로고
    • KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer
    • Li H, Lu Y, An Y, Wang X, Zhao QC, (2011) KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer. Oncol Rep 25: 1691-1697.
    • (2011) Oncol Rep , vol.25 , pp. 1691-1697
    • Li, H.1    Lu, Y.2    An, Y.3    Wang, X.4    Zhao, Q.C.5
  • 30
    • 84860635583 scopus 로고    scopus 로고
    • PIK3CA mutations and expressions status of PTEN in Guangxi Zhuang populations colorectal cancer and their relationship
    • Huang WF, Peng LY, Jiang JK, Li X, Chen L, (2010) PIK3CA mutations and expressions status of PTEN in Guangxi Zhuang populations colorectal cancer and their relationship. Med J Chin PAPF 21: 925-929.
    • (2010) Med J Chin PAPF , vol.21 , pp. 925-929
    • Huang, W.F.1    Peng, L.Y.2    Jiang, J.K.3    Li, X.4    Chen, L.5
  • 31
    • 84860634396 scopus 로고    scopus 로고
    • PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
    • doi:10.1093/annonc/mdr464
    • Mao C, Yang ZY, Hu XF, Chen Q, Tang JL, (2011) PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Ann Oncol doi:10.1093/annonc/mdr464.
    • (2011) Ann Oncol
    • Mao, C.1    Yang, Z.Y.2    Hu, X.F.3    Chen, Q.4    Tang, J.L.5
  • 33
    • 66849140563 scopus 로고    scopus 로고
    • PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer
    • Loupakis F, Pollina L, Stasi I, Ruzzo A, Scartozzi M, et al. (2009) PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer. Journal of Clinical Oncology 27: 2622-2629.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 2622-2629
    • Loupakis, F.1    Pollina, L.2    Stasi, I.3    Ruzzo, A.4    Scartozzi, M.5
  • 34
    • 70350028742 scopus 로고    scopus 로고
    • Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer
    • Sartore-Bianchi A, Di Nicolantonio F, Nichelatti M, Molinari F, De Dosso S, et al. (2009) Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer. PLoS One 2 4: e7287.
    • (2009) PLoS One , vol.2-4
    • Sartore-Bianchi, A.1    Di Nicolantonio, F.2    Nichelatti, M.3    Molinari, F.4    de Dosso, S.5
  • 35
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer
    • Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, et al. (2009) Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer. Journal of Clinical Oncology 27: 5924-5930.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.B.5
  • 36
    • 84860649959 scopus 로고    scopus 로고
    • Expressions of CD44v6 and PTEN in colorectal cancer and correlation study. (in Chinese)
    • He X, He X, Zheng J, (2009) Expressions of CD44v6 and PTEN in colorectal cancer and correlation study. (in Chinese). Modern Practical Medcine 21: 698-699.
    • (2009) Modern Practical Medcine , vol.21 , pp. 698-699
    • He, X.1    He, X.2    Zheng, J.3
  • 37
    • 84860633240 scopus 로고    scopus 로고
    • Expression of CDX2,PTEN,Ki-67 and their correlativity of DNA ploidy in colorectal carcinoma(in Chinese)
    • Lu X, Qi G, Yang Z, (2009) Expression of CDX2,PTEN,Ki-67 and their correlativity of DNA ploidy in colorectal carcinoma(in Chinese). Cancer Research and Clinic 21: 588-90,596.
    • (2009) Cancer Research and Clinic , vol.21
    • Lu, X.1    Qi, G.2    Yang, Z.3
  • 38
    • 74249093155 scopus 로고    scopus 로고
    • PTEN status in advanced colorectal cancer treated with cetuximab
    • Negri F, Bozzetti C, Lagrasta C, Crafa P, et al. (2010) PTEN status in advanced colorectal cancer treated with cetuximab. Br J Cancer 102: 162-164.
    • (2010) Br J Cancer , vol.102 , pp. 162-164
    • Negri, F.1    Bozzetti, C.2    Lagrasta, C.3    Crafa, P.4


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