Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology

Human Pathology

Volumn 29, Issue 1, 1998, Pages 34-40

  Mandai, M ^a   Konishi, I ^a   Kuroda, H ^a   Komatsu, T ^a   Yamamoto, S ^a   Nanbu, K ^a   Matsushita, K ^a   Fukumoto, M ^a   Yamabe, H ^a   Mori, T ^a  

^a KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

Adenoma carcinoma sequence; Heterogeneity; K ras mutation; Microdissection; Mucinous ovarian tumor

Indexed keywords

ADENOMA; ARTICLE; CANCER INVASION; CARCINOGENESIS; CHROMOSOME MICRODISSECTION; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALIGNANT TRANSFORMATION; ONCOGENE K RAS; OVARY TUMOR; POLYMERASE CHAIN REACTION; SALPINGOOOPHORECTOMY; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0031964463     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(98)90387-2     Document Type: Article

References (28)

1. National Institutes of Health Ovarian cancer: Screening, treatment, and follow up NIH Consensus Statement 12 1994 1 30
2. A Okamoto Y Sameshima S Yokoyama Frequent allelic losses and mutations of the p53 gene in human ovarian cancer Cancer Res 51 1991 5171 5176
3. JR Marks AM Davidoff BJ Kerns Overexpression and mutation of p53 in epithelial ovarian cancer Cancer Res 51 1991 2979 2984
4. M Koshiyama I Konishi M Mandai Immunohistochemical analysis of p53 protein and 72 kDa heat shock protein (HSP72) expression in ovarian carcinomas: Correlation with clinicopathology and sex steroid receptor status Virchows Arch 425 1995 603 609
5. DJ Slamon W Godolphin LA Jones Studies of HER-2/ neu proto-oncogene in human breast and ovarian cancer Science 244 1989 707 712
6. A Berchuck A Kamel R Whitaker Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer Cancer Res 50 1990 4087 4091
7. M Mandai I Konishi M Koshiyama Expression of metastasis-related nm23-H1 and nm23-H2 genes in ovarian carcinomas: Correlation with clinicopathology, EGFR , c- erb B-2, and c- erb B-3 genes, and sex steroid receptor expression Cancer Res 54 1994 1825 1830
8. T Enomoto CM Weghorst M Inoue K- ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary Am J Pathol 139 1991 777 785
9. Y Ichikawa M Nishida H Suzuki Mutation of K- ras protooncogene is associated with histological subtypes in human mucinous ovarian tumors Cancer Res 54 1994 33 35
10. M Mandai I Konishi T Komatsu Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K- ras mutation in ovarian carcinoma: Correlation with tumor progression and nm23 gene expression Br J Cancer 72 1995 691 695
11. DE Powell L Puls J van Nagell Current concepts in epithelial ovarian tumors: Does benign to malignant transformation occur? Hum Pathol 23 1992 846 847
12. RE Scully Tumors of the ovary and maldeveloped gonads ed 2 Atlas of Tumor Pathology 1979 Armed Forces Institute of Pathology Washington, DC 75 91 2nd series, Fascicle 16
13. DA Bell RE Scully Early de novo ovarian carcinoma: A study of fourteen cases Cancer 73 1994 1859 1864
14. LE Puls DE Powell PD Depriest Transition from benign to malignant epithelium in mucinous and serous ovarian cystadenocarcinoma Gynecol Oncol 47 1992 53 57
15. Z Zhuang P Bertheau MR Emmert-Buck A microdissection technique for archival DNA analysis of specific cell populations in lesions <1 mm in size Am J Pathol 146 1995 620 625
16. BJ Youngson A Anelli KJ van Zee Microdissection and molecular genetic analysis of HER2/neu in breast carcinoma Am J Surg Pathol 19 1995 1354 1358
17. M Ohue N Tomita T Monden A frequent alterations of p53 gene in carcinoma in adenoma of colon Cancer Res 54 1994 4798 4804
18. WR Hart HJ Norris Borderline and malignant mucinous tumors of the ovary: Histologic criteria and clinical behavior Cancer 31 1973 1031 1045
19. SC Mok DA Bell RC Knapp Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy Cancer Res 53 1993 1489 1492
20. MG Teneriello M Ebina RI Linnoila p53 and Ki- ras gene mutations in epithelial ovarian neoplasms Cancer Res 53 1993 3103 3108
21. A Yanagisawa K Ohtake K Ohnishi Frequent c-Ki-ras oncogene activation in mucous cell hyperplasia of pancreas suffering from chronic inflammation Cancer Res 53 1993 953 956
22. T Kobayashi H Tsuda M Noguchi Association of point mutation in c-Ki- ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes Cancer 66 1990 289 294
23. H Miki M Ohmori AO Perantoni K- ras activation in gastric epithelial tumors in Japanese Cancer Letters 58 1991 107 113
24. ER Fearon B Vogelstein A genetic model for colorectal tumorigenesis Cell 61 1990 759 767
25. A Berchuck MF Kohler MP Hopikins Overexpression of p53 is not a feature of benign and early-stage borderline epithelial ovarian tumors Gynecol Oncol 52 1994 232 236
26. RJ Kurman CL Trimble The behavior of serous tumors of low malignant potential: Are they ever malignant? Int J Gynecol Pathol 12 1993 120 127
27. J Zheng M Wan S Zweizig Histologically benign or low-grade malignant tumors adjacent to high grade ovarian carcinomas contain molecular characteristics of high-grade carcinomas Cancer Res 53 1993 4138 4142
28. J Zheng WF Benedict HJ Xu Genetic disparity between morphologically benign cysts contiguous to ovarian carcinoma and solitary cystadenomas J Natl Cancer Inst 87 1995 1146 1153