Expression of p53, DCC, and HER-2/neu in mucinous carcinoma of the breast

Kaohsiung Journal of Medical Sciences

Volumn 21, Issue 5, 2005, Pages 197-202

  Hsu, Yung Hsiang ^a   Shaw, Cheng Kuang ^a  

^a BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

Author keywords

Breast cancer; DCC; HER 2 neu; Mucinous carcinoma; p53

Indexed keywords

CHROMOGENIC SUBSTRATE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; MUCIN; ONCOPROTEIN; PROGESTERONE RECEPTOR; PROTEIN P53;

ADULT; AGE; ARTICLE; BREAST CARCINOMA; CHROMOSOME 17Q; CONTROLLED STUDY; DCC GENE; FEMALE; GENE EXPRESSION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MUCINOUS CARCINOMA; PROGNOSIS; STATISTICAL ANALYSIS; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

EID: 20444380691     PISSN: 02575655     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1607-551x(09)70188-3     Document Type: Article

References (25)

1. Weinberg RA. Tumor suppressor genes. Science 1991;254: 1138-45.
2. Fearon ER, Cho KR, Nigro JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990;247:49-56.
3. Vogelstein B, Fearon ER, Kern SE, et al. Allelotype of colorectal carcinomas. Science 1989;244:207-11.
4. Itoh F, Hinoda Y, Ohe M, et al. Decreased expression of DCC mRNA in human colorectal cancer. Int J Cancer 1993;53:260-3.
5. Jen J, Kim H, Piantadosi S, et al. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 1994; 331:213-21.
6. Kashiwaba M, Tamura G, Ishida M. Frequent loss of heterozygosity at the deleted colorectal carcinoma gene locus and its association with histologic phenotypes in breast carcinoma. Virchows Arch 1995;426:441-6.
7. Wakita K, Kohno N, Sakoda Y, et al. Decreased expression of the DCC gene in human breast carcinoma. Surg Today 1996; 26:900-3.
8. Ho KY, Kalle WH, Lo TH, et al. Reduced expression of APC and DCC gene protein in breast cancer. Histopathology 1999; 35:249-56.
9. Donehower LA, Bradley A. The tumor suppressor p53. Biochem Biophys Acta 1993;1155:181-205.
10. Lipponen P, Ji H, Aaltomaa S, et al. p53 protein expression in breast cancer as related to histopathological characteristics and prognosis. Int J Cancer 1993;55:51-6.
11. Slamon DJ, Godolphin W, Jones LA, et al. Studies of HER-2/ neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12.
12. Komaki K, Sakamoto G, Sugano H, et al. Mucinous carcinoma of the breast in Japan. A prognostic analysis based on morphologic features. Cancer 1988;61:989-96.
13. Scopsi L, Andreola S, Pilotti S, et al. Mucinous carcinoma of the breast. A clinicopathologic, histochemical, and immunocytochemical study with special reference to neuroendocrine differentiation. Am J Surg Pathol 1994; 18:702-11.
14. Toikkanen S, Kujari H. Pure and mixed mucinous carcinomas of the breast: a clinicopathologic analysis of 61 cases with long-term follow-up. Hum Pathol 1989;20:758-64.
15. Avisar E, Khan MA, Axelrod D, Oza K. Pure mucinous carcinoma of the breast: a clinicopathologic correlation study. Ann Surg Oncol 1998;5:447-51.
16. Chuong CM, Jiang TX, Yin E, Widelitz RB. cDCC (chicken homologue to gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial-mesenchymal interaction. Dev Biol 1994; 164:383-97.
17. Brown RW, Chirala R. Utility of microwave-citrate antigen retrieval in diagnostic immunohistochemistry. Mod Pathol 1995;8:515-20.
18. Shibata D, Reale MA, Lavin P, et al. The DCC protein and prognosis in colorectal cancer. N Engl J Med 1996;335:1727-32.
19. Press MF, Pike MC, Hung G, et al. Amplification and overexpression of HER-2/neu in carcinomas of the salivary gland: correlation with poor prognosis. Cancer Res 1994;54: 5675-82.
20. Hedrick L, Cho KR, Fearon ER, et al. The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Dev 1994;8:1174-83.
21. Saegusa M, Okayasu I. DCC expression is related to mucinous differentiation but not changes in expression of p21(WAF1/ Cip1) and p27Kip1, apoptosis, cell proliferation and human papillomavirus infection in uterine cervical adenocarcinomas. Br J Cancer 1999;80:51-8.
22. Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-82.
23. Bland KI, Konstadoulakis MM, Vezeridis MP, Wanebo HJ. Oncogene protein coexpression. Value of Ha-ras, c-myc, c-fos, and p53 as prognostic discriminants for breast carcinoma. Ann Surg 1995;211:706-18.
24. Shousha S, Coady AT, Stamp T, et al. Estrogen receptors in mucinous carcinoma of the breast: an immunohistochemical study using paraffin wax sections. J Clin Pathol 1989;42:902-5.
25. Chu JS, Chang KJ. Mucin expression in mucinous carcinoma and other invasive carcinomas of the breast. Cancer Lett 1999; 142:121-7.