Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver

Drug Metabolism and Disposition

Volumn 36, Issue 7, 2008, Pages 1202-1205

  Kitamura, Shigeyuki ^a,b,c   Nitta, Kayoko ^a,b,c   Tayama, Yoshitaka ^a,b,c   Tanoue, Chiaki ^a,b,c   Sugihara, Kazumi ^a,b,c   Inoue, Tae ^a,b,c   Horie, Toru ^a,b,c   Ohta, Shigeru ^a,b,c  

^a HIROSHIMA UNIVERSITY   (Japan)

^b PhoenixBio   (Japan)

^c NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLNICOTINAMIDE; ALDEHYDE OXIDASE; N1 METHYL 2 PYRIDINE 5 CARBOXAMIDE; N1 METHYL 4 PYRIDONE 5 CARBOXAMIDE; PYRIDONE DERIVATIVE; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EXCRETION; DRUG METABOLISM; DRUG OXIDATION; DRUG URINE LEVEL; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SINGLE DRUG DOSE; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALDEHYDE OXIDASE; ANIMALS; CATALYSIS; CHIMERA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LIVER; MICE; MICE, SCID; NIACINAMIDE;

MUS;

EID: 46449106279     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.019075     Document Type: Article

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