Regulation of intestinal cytochrome p450 expression by hepatic cytochrome p450: Possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure

Molecular Pharmacology

Volumn 85, Issue 1, 2014, Pages 139-147

  Zhu, Yi ^a   Ding, Xinxin ^a   Fang, Cheng ^a   Zhang, Qing Yu ^a  

^a NEW YORK STATE DEPARTMENT OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALPH MURICHOLIC ACID; BETA MUROCHOLIC ACID; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B; CYTOCHROME P450 2C; CYTOCHROME P450 3A; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 19; GAMMA INTERFERON; GASTROINTESTINAL HORMONE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; MESSENGER RNA; MEVINOLIN; PREGNANE X RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; SIMVASTATIN; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EXPOSURE; DRUG HALF LIFE; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; FIRST PASS EFFECT; GENETIC TRANSCRIPTION; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE;

EID: 84890671843     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.088914     Document Type: Article

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