Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism

Xenobiotica

Volumn 41, Issue 6, 2011, Pages 464-475

  Serres, Mark D E ^a   Bowers, Gary ^a   Boyle, Gary ^b   Beaumont, Claire ^b   Castellino, Steve ^a   Sigafoos, James ^a   Dave, Mehul ^b   Roberts, Andrew ^b   Shah, Vishal ^a   Olson, Katie ^a   Patel, Dipak ^a   Wagner, David ^a   Yeager, Russell ^a   Serabjit Singh, Cosette ^a  

^a GLAXOSMITHKLINE   (United States)

^b Ware   (United Kingdom)

Author keywords

(uPA+ +) SCID; Chimeric mouse; human hepatocyte; liver; metabolism

Indexed keywords

DENAGLIPTIN; GW 695634; SB 406725; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DOSE ESCALATION; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PREDICTION; SCID MOUSE; SINGLE DRUG DOSE; URINARY EXCRETION;

ANIMALS; BENZOPHENONES; CHIMERA; FEMALE; HUMANS; LIVER; MALE; MICE; MICE, SCID; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHENYLALANINE; PYRROLIDINES; SULFONAMIDES; TETRAHYDROISOQUINOLINES;

MUS;

EID: 79956361372     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.560295     Document Type: Article

References (22)

1. Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M. (2007). Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/-mice. Nat Biotechnol 25:903-910.
2. Cheng Z, Herron C, Bowers G, de Serres M. (2006). Assessment of cryopreserved hepatocytes as an alternative to fresh hepatocytes for comparative interspecies metabolism studies with suitable acceptance criteria. Drug Metabolism Letters 1: 109-120.
3. Dear GJ, Roberts AD, Beaumont C, North SE. (2008). Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 876: 182-190.
4. de Serres M, Moss L, Sigafoos J, Sefer A, Castellino S, Bowers G, Serabjit-Singh C. (2010). Te disposition and metabolism of GW695634: a non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS. Xenobiotica 40: 437-445.
5. Ekins S, Ring BJ, Grace J, McRobie-Belle DJ, Wrighton SA. (2000). Present and future in vitro approaches for drug metabolism. J Pharmacol Toxicol Methods 44:313-324. (Pubitemid 32239483)
6. Inoue T, Nitta K, Sugihara K, Horie T, Kitamura S, Ohta S. (2008). CYP2C9-catalized metabolism of S-Warfn to 7-Hydroxywarfn in vivo and in vitro in chimeric mice with humanized liver. Drug Metabolism and Disposition 36:2429-2433.
7. Inoue T, Sugihara K, Ohshita H, Horie T, Kitamura S, Ohta S. (2009). Prediction of human disposition toward S-3H-warfarin using chimeric mice with humanized liver. Drug Metab Pharmacokinet 24:153-160.
8. Katoh M, Sawada T, Soeno Y, Nakajima M, Tateno C, Yoshizato K, Yokoi T. (2007). In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver. J Pharm Sci 96:428-437. (Pubitemid 46363572)
9. Katoh M, Yokoi T. (2007). Application of chimeric mice with humanized liver for predictive ADME. Drug Metab Rev 39:145-157.
10. Katoh M, Tateno C, Yoshizato K, Yokoi T. (2008). Chimeric mice with humanized liver. Toxicology 246:9-17.
11. Lootens L, Meuleman P, Pozo OJ, Van Eenoo P, Leroux-Roels G, Delbeke FT. (2009). uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study. Clin Chem 55:1783-1793.
12. Meuleman P, Libbrecht L, De Vos R, de Hemptinne B, Gevaert K, Vandekerckhove J, Roskams T, Leroux-Roels G. (2005). Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology 41: 847-856. (Pubitemid 40462948)
13. ® mice with humanized liver. Toxicological Sciences 97:533-538. (Pubitemid 47073867)
14. Peterson RA, Krull DL, Brown HR, de Serres M. (2010). Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model. Drug Metab Lett 4: 180-184.
15. Prous J. (2004). Annual Update 2003/2004-Treatment of Neurological Disorders. Drugs of the Future 29:253-317.
16. Romines KR, Freeman GA, Schaller LT, Cowan JR, Gonzales SS, Tidwell JH, Andrews CW 3rd, Stammers DK, Hazen RJ, Ferris RG, Short SA, Chan JH, Boone LR. (2006). Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor. J Med Chem 49:727-739. (Pubitemid 43157502)
17. gnull mice. Biochemical and Biophysical Research Communications 377:248-252.
18. Sato Y, Yamada H, Iwasaki K, Tateno C, Yokoi T, Yoshizato K, Horii I. (2008). Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen. Toxicol Pathol 36: 581-591.
19. Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, Tachibana A, Soeno Y, Asahina K, Hino H, Asahara T, Yokoi T, Furukawa T, Yoshizato K. (2004). Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol 165:901-912. (Pubitemid 39129297)
20. Utoh R, Tateno C, Kataoka M, Tachibana A, Masumoto N, Yamasaki C, Shimada T, Itamoto T, Asahara T, Yoshizato K. (2010). Hepatic hyperplasia associated with discordant xenogeneic parenchymal-nonparenchymal interactions in human hepatocyte-repopulated mice. Am J Pathol 177:654-665.
21. Wua J, Chenb Y, Shia X, Gua W. (2009). Dipeptidyl peptidase IV(DPP IV): a novel emerging target for the treatment of type 2 diabetes. Journal of Nanjing Medical University 23: 228-235.
22. Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S. (2010). Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry. Chem Res Toxicol 23: 152-158.