Identification of distinct conformations of the angiotensin-II type 1 receptor associated with the Gq/11 protein pathway and the β-arrestin pathway using molecular dynamics simulations

Journal of Biological Chemistry

Volumn 290, Issue 25, 2015, Pages 15835-15854

  Cabana, Jérôme ^a,c   Holleran, Brian ^a   Leduc, Richard ^a   Escher, Emanuel ^a   Guillemette, Gaétan ^a   Lavigne, Pierre ^b,c  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITY OF SHERBROOKE   (Canada)

^c UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; GROUND STATE; LIGANDS; PROTEINS;

ANGIOTENSIN II; AT1-RECEPTOR; CONFORMATIONAL TRANSITIONS; CONSTITUTIVELY ACTIVES; G PROTEIN COUPLED RECEPTORS; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN PATHWAYS; STRUCTURAL REARRANGEMENT;

MOLECULAR DYNAMICS;

ANGIOTENSIN 1 RECEPTOR; ASPARAGINE; ASPARTIC ACID; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; GLYCINE; ISOLEUCINE; PROTEIN GQ 11; SERINE; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PROTEIN BINDING; RETINA S ANTIGEN;

ALPHA HELIX; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; WILD TYPE; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE;

AMINO ACID SUBSTITUTION; ARRESTINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; RECEPTOR, ANGIOTENSIN, TYPE 1; SIGNAL TRANSDUCTION;

EID: 84940203325     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.627356     Document Type: Article

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