The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 18872-18884

  Wilson, Parker C ^a   Lee, Mi Hye ^a   Appleton, Kathryn M ^b   El Shewy, Hesham M ^a   Morinelli, Thomas A ^a   Peterson, Yuri K ^b   Luttrell, Louis M ^a,c   Jaffa, Ayad A ^a,d  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^d AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATION; INTRACELLULAR CALCIUM; LIGAND-BINDING SITES; RADIOLIGAND BINDING; RECEPTOR ACTIVATION; RECEPTOR SIGNALING; RENIN-ANGIOTENSIN SYSTEM; VASCULAR SMOOTH MUSCLE CELLS;

BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION;

LIGANDS;

ADENYLATE CYCLASE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II [1 SARCOSINE 4 ISOLEUCINE 8 ISOLEUCINE]; ANGIOTENSIN II DERIVATIVE; ARRESTIN 3; BRADYKININ; BRADYKININ B2 RECEPTOR; CALCIUM; HETERODIMER; KALLIKREIN; KININ; LOSARTAN; RENIN; RETINA S ANTIGEN; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; LIGAND BINDING; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANGIOTENSIN; ARRESTIN; BIASED AGONISM; BRADYKININ; G PROTEIN-COUPLED RECEPTORS (GPCR); G PROTEINS; HETERODIMERIZATION; SEQUESTRATION; SIGNAL TRANSDUCTION;

ALLOSTERIC SITE; ANGIOTENSIN II; ANIMALS; AORTA; ARRESTINS; CALCIUM; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; HEK293 CELLS; HEMODYNAMICS; HUMANS; KALLIKREINS; LIGANDS; LOSARTAN; MYOCYTES, SMOOTH MUSCLE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, BRADYKININ B2; SIGNAL TRANSDUCTION;

EID: 84879563066     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.472381     Document Type: Article

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