Manifold active-state conformations in GPCRs: Agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor

FEBS Letters

Volumn 581, Issue 13, 2007, Pages 2517-2522

  Lee, ChangWoo ^a,b   Hwang, Si Ae ^b   Jang, Sei Heon ^b   Chung, Hye Shin ^c   Bhat, Manjunatha B ^a   Karnik, Sadashiva S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Daegu University   (South Korea)

^c Hannam University   (South Korea)

Author keywords

Arrestin; Angiotensin II receptor; G protein

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; BETA ARRESTIN 1; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SUBSTITUTION; ANIMALS; ARRESTINS; ASPARAGINE; BINDING SITES; CALCIUM; CALCIUM SIGNALING; CLONING, MOLECULAR; GLYCINE; KINETICS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS;

EID: 34248578204     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.04.069     Document Type: Article

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