Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery

Journal of Controlled Release

Volumn 205, Issue , 2015, Pages 231-239

  Zheng, Nan ^a   Song, Ziyuan ^a   Liu, Yang ^a   Zhang, Rujing ^a   Zhang, Ruoyan ^a   Yao, Catherine ^a   Uckun, Fatih M ^b   Yin, Lichen ^c   Cheng, Jianjun ^a  

^a University of Illinois at Urbana Champaign   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

Cationic helical polypeptide; Complex stability siRNA encapsulation; Crosslinking; RNA interference; Thiolation

Indexed keywords

COVALENT BONDS; CROSSLINKING; GENES; RNA; SULFUR COMPOUNDS;

CELLULAR INTERNALIZATION; COMPLEX STABILITY; CROSS-LINKED COMPLEX; EXTRACELLULAR ENVIRONMENTS; HELICAL POLYPEPTIDES; RNA INTERFERENCE; SECONDARY STRUCTURES; THIOLATION;

PEPTIDES;

CATION; CROSS LINKING REAGENT; GLUTATHIONE; LUCIFERASE; PEPTIDE; PIPERIDINE DERIVATIVE; POLY(GAMMA-(4-((2-(PIPERIDIN-1-YL)ETHYL)AMINOMETHYL)BENZYL)GLUTAMATE); POLYGLUTAMIC ACID; SMALL INTERFERING RNA; THIOL DERIVATIVE;

ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMISTRY; CONFORMATION; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HELA CELL LINE; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; PROCEDURES; PROTEIN SECONDARY STRUCTURE; REPORTER GENE; RNA INTERFERENCE; RNA STABILITY; RNAI THERAPEUTICS;

CATIONS; CELL SURVIVAL; CROSS-LINKING REAGENTS; GENES, REPORTER; GLUTATHIONE; HELA CELLS; HUMANS; LUCIFERASES; NUCLEIC ACID CONFORMATION; OXIDATION-REDUCTION; PEPTIDES; PIPERIDINES; POLYGLUTAMIC ACID; PROTEIN STRUCTURE, SECONDARY; RNA INTERFERENCE; RNA STABILITY; RNA, SMALL INTERFERING; RNAI THERAPEUTICS; SULFHYDRYL COMPOUNDS; TRANSFECTION;

EID: 84939971061     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.02.014     Document Type: Article

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