메뉴 건너뛰기




Volumn 172, Issue 1, 2013, Pages 207-218

Chitosan-based siRNA delivery systems

Author keywords

Chitosan; Delivery barriers; Ligand; Nanoparticles; RNA interference; siRNA

Indexed keywords

BIOLOGICAL FLUIDS; DELIVERY BARRIERS; RNA INTERFERENCE; SIRNA; SMALL INTERFERING RNA (SIRNA); SYSTEMIC DELIVERIES; TARGETING LIGANDS; THERAPEUTIC APPLICATION;

EID: 84883878577     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.08.005     Document Type: Review
Times cited : (230)

References (70)
  • 1
    • 75149133614 scopus 로고    scopus 로고
    • Chitosan-based formulations for delivery of DNA and siRNA
    • S. Mao, W. Sun, and T. Kissel Chitosan-based formulations for delivery of DNA and siRNA Adv. Drug Deliv. Rev. 62 2010 12 27
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 12-27
    • Mao, S.1    Sun, W.2    Kissel, T.3
  • 2
    • 33749844509 scopus 로고    scopus 로고
    • Development and characterisation of chitosan nanoparticles for siRNA delivery
    • DOI 10.1016/j.jconrel.2006.07.021, PII S0168365906003683
    • H. Katas, and H.O. Alpar Development and characterisation of chitosan nanoparticles for siRNA delivery J. Control. Release 115 2006 216 225 (Pubitemid 44559708)
    • (2006) Journal of Controlled Release , vol.115 , Issue.2 , pp. 216-225
    • Katas, H.1    Alpar, H.O.2
  • 3
    • 33751419974 scopus 로고    scopus 로고
    • The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing
    • DOI 10.1016/j.biomaterials.2006.11.004, PII S0142961206009501
    • X. Liu, K.A. Howard, M. Dong, M.O. Andersen, U.L. Rahbek, M.G. Johnsen, O.C. Hansen, F. Besenbacher, and J. Kjems The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing Biomaterials 28 2007 1280 1288 (Pubitemid 44816373)
    • (2007) Biomaterials , vol.28 , Issue.6 , pp. 1280-1288
    • Liu, X.1    Howard, K.A.2    Dong, M.3    Andersen, M.O.4    Rahbek, U.L.5    Johnsen, M.G.6    Hansen, O.C.7    Besenbacher, F.8    Kjems, J.9
  • 4
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • A.L. Jackson, and P.S. Linsley Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application Nat. Rev. Drug Discov. 9 2010 57 67
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 5
    • 77249111686 scopus 로고    scopus 로고
    • The safety of chitosan as a pharmaceutical excipient
    • P. Baldrick The safety of chitosan as a pharmaceutical excipient Regul. Toxicol. Pharmacol. 56 2010 290 299
    • (2010) Regul. Toxicol. Pharmacol. , vol.56 , pp. 290-299
    • Baldrick, P.1
  • 7
    • 84862646294 scopus 로고    scopus 로고
    • Chitosan-based drug nanocarriers: Where do we stand?
    • M. Garcia-Fuentes, and M.J. Alonso Chitosan-based drug nanocarriers: where do we stand? J. Control. Release 161 2012 496 504
    • (2012) J. Control. Release , vol.161 , pp. 496-504
    • Garcia-Fuentes, M.1    Alonso, M.J.2
  • 10
    • 84863418151 scopus 로고    scopus 로고
    • Action and reaction: The biological response to siRNA and its delivery vehicles
    • R.L. Kanasty, K.A. Whitehead, A.J. Vegas, and D.G. Anderson Action and reaction: the biological response to siRNA and its delivery vehicles Mol. Ther. 20 2012 513 524
    • (2012) Mol. Ther. , vol.20 , pp. 513-524
    • Kanasty, R.L.1    Whitehead, K.A.2    Vegas, A.J.3    Anderson, D.G.4
  • 11
    • 67649295505 scopus 로고    scopus 로고
    • SiRNA delivery systems for cancer treatment
    • Y.K. Oh, and T.G. Park siRNA delivery systems for cancer treatment Adv. Drug Deliv. Rev. 61 2009 850 862
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 850-862
    • Oh, Y.K.1    Park, T.G.2
  • 12
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
    • DOI 10.1016/S0142-9612(02)00445-3, PII S0142961202004453
    • D. Fischer, Y. Li, B. Ahlemeyer, J. Krieglstein, and T. Kissel In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 24 2003 1121 1131 (Pubitemid 36069121)
    • (2003) Biomaterials , vol.24 , Issue.7 , pp. 1121-1131
    • Fischer, D.1    Li, Y.2    Ahlemeyer, B.3    Krieglstein, J.4    Kissel, T.5
  • 13
    • 84869194894 scopus 로고    scopus 로고
    • Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions
    • B. Ballarin-Gonzalez, and K.A. Howard Polycation-based nanoparticle delivery of RNAi therapeutics: adverse effects and solutions Adv. Drug Deliv. Rev. 64 2012 1717 1729
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 1717-1729
    • Ballarin-Gonzalez, B.1    Howard, K.A.2
  • 14
    • 84863903929 scopus 로고    scopus 로고
    • Nucleic acid delivery: The missing pieces of the puzzle?
    • J. Nguyen, and F.C. Szoka Nucleic acid delivery: the missing pieces of the puzzle? Acc. Chem. Res. 45 2012 1153 1162
    • (2012) Acc. Chem. Res. , vol.45 , pp. 1153-1162
    • Nguyen, J.1    Szoka, F.C.2
  • 15
    • 84862118004 scopus 로고    scopus 로고
    • Analysis of immediate stress mechanisms upon injection of polymeric micelles and related colloidal drug carriers: Implications on drug targeting
    • T. Miller, A. Hill, S. Uezguen, M. Weigandt, and A. Goepferich Analysis of immediate stress mechanisms upon injection of polymeric micelles and related colloidal drug carriers: implications on drug targeting Biomacromolecules 13 2012 1707 1718
    • (2012) Biomacromolecules , vol.13 , pp. 1707-1718
    • Miller, T.1    Hill, A.2    Uezguen, S.3    Weigandt, M.4    Goepferich, A.5
  • 19
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • S.K. Lai, Y.Y. Wang, and J. Hanes Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues Adv. Drug Deliv. Rev. 61 2009 158 171
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 158-171
    • Lai, S.K.1    Wang, Y.Y.2    Hanes, J.3
  • 20
    • 84865331409 scopus 로고    scopus 로고
    • Topical drug delivery using chitosan nano- and microparticles
    • A.D. Sezer, and E. Cevher Topical drug delivery using chitosan nano- and microparticles Expert Opin. Drug Deliv. 9 2012 1129 1146
    • (2012) Expert Opin. Drug Deliv. , vol.9 , pp. 1129-1146
    • Sezer, A.D.1    Cevher, E.2
  • 21
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-targeted therapeutics in anticancer therapy
    • DOI 10.1038/nrc903
    • T.M. Allen Ligand-targeted therapeutics in anticancer therapy Nat. Rev. Cancer 2 2002 750 763 (Pubitemid 37328910)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.10 , pp. 750-763
    • Allen, T.M.1
  • 22
    • 19744372388 scopus 로고    scopus 로고
    • Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis
    • DOI 10.1002/jgm.696
    • A. Akinc, M. Thomas, A.M. Klibanov, and R. Langer Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis J. Gene Med. 7 2005 657 663 (Pubitemid 40744532)
    • (2005) Journal of Gene Medicine , vol.7 , Issue.5 , pp. 657-663
    • Akinc, A.1    Thomas, M.2    Klibanov, A.M.3    Langer, R.4
  • 23
    • 84871918550 scopus 로고    scopus 로고
    • The possible "proton sponge " effect of polyethylenimine (PEI) does not include change in lysosomal pH
    • R.V. Benjaminsen, M.A. Mattebjerg, J.R. Henriksen, S.M. Moghimi, and T.L. Andresen The possible "proton sponge " effect of polyethylenimine (PEI) does not include change in lysosomal pH Mol. Ther. 21 2013 149 157
    • (2013) Mol. Ther. , vol.21 , pp. 149-157
    • Benjaminsen, R.V.1    Mattebjerg, M.A.2    Henriksen, J.R.3    Moghimi, S.M.4    Andresen, T.L.5
  • 24
    • 21744437897 scopus 로고    scopus 로고
    • Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes
    • DOI 10.1016/j.jconrel.2005.03.024, PII S0168365905001331
    • T.H. Kim, S.I. Kim, T. Akaike, and C.S. Cho Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes J. Control. Release 105 2005 354 366 (Pubitemid 40941999)
    • (2005) Journal of Controlled Release , vol.105 , Issue.3 , pp. 354-366
    • Tae, H.K.1    Su, I.K.2    Akaike, T.3    Chong, S.C.4
  • 25
    • 61349123258 scopus 로고    scopus 로고
    • Nucleic acid delivery with chitosan and its derivatives
    • W.F. Lai, and M.C. Lin Nucleic acid delivery with chitosan and its derivatives J. Control. Release 134 2009 158 168
    • (2009) J. Control. Release , vol.134 , pp. 158-168
    • Lai, W.F.1    Lin, M.C.2
  • 26
    • 84875819123 scopus 로고    scopus 로고
    • Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: Optimization studies
    • J.C. Fernandes, X. Qiu, F.M. Winnik, M. Benderdour, X. Zhang, K. Dai, and Q. Shi Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: optimization studies Int. J. Nanomedicine 7 2012 5833 5845
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 5833-5845
    • Fernandes, J.C.1    Qiu, X.2    Winnik, F.M.3    Benderdour, M.4    Zhang, X.5    Dai, K.6    Shi, Q.7
  • 28
    • 84655167822 scopus 로고    scopus 로고
    • Phosphorylatable short peptide conjugated low molecular weight chitosan for efficient siRNA delivery and target gene silencing
    • F. Kong, G. Liu, B. Sun, S. Zhou, A. Zuo, R. Zhao, and D. Liang Phosphorylatable short peptide conjugated low molecular weight chitosan for efficient siRNA delivery and target gene silencing Int. J. Pharm. 422 2012 445 453
    • (2012) Int. J. Pharm. , vol.422 , pp. 445-453
    • Kong, F.1    Liu, G.2    Sun, B.3    Zhou, S.4    Zuo, A.5    Zhao, R.6    Liang, D.7
  • 29
    • 84855772609 scopus 로고    scopus 로고
    • Biophysical properties of chitosan/siRNA polyplexes: Profiling the polymer/siRNA interactions and bioactivity
    • P. Holzerny, B. Ajdini, W. Heusermann, K. Bruno, M. Schuleit, L. Meinel, and M. Keller Biophysical properties of chitosan/siRNA polyplexes: profiling the polymer/siRNA interactions and bioactivity J. Control. Release 157 2012 297 304
    • (2012) J. Control. Release , vol.157 , pp. 297-304
    • Holzerny, P.1    Ajdini, B.2    Heusermann, W.3    Bruno, K.4    Schuleit, M.5    Meinel, L.6    Keller, M.7
  • 30
    • 84858709347 scopus 로고    scopus 로고
    • SiRNA delivery with chitosan nanoparticles: Molecular properties favoring efficient gene silencing
    • J. Malmo, H. Sorgard, K.M. Varum, and S.P. Strand siRNA delivery with chitosan nanoparticles: molecular properties favoring efficient gene silencing J. Control. Release 158 2012 261 268
    • (2012) J. Control. Release , vol.158 , pp. 261-268
    • Malmo, J.1    Sorgard, H.2    Varum, K.M.3    Strand, S.P.4
  • 31
    • 84864711649 scopus 로고    scopus 로고
    • An inhalable beta(2)-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung
    • Y. Luo, X. Zhai, C. Ma, P. Sun, Z. Fu, W. Liu, and J. Xu An inhalable beta(2)-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung J. Control. Release 162 2012 28 36
    • (2012) J. Control. Release , vol.162 , pp. 28-36
    • Luo, Y.1    Zhai, X.2    Ma, C.3    Sun, P.4    Fu, Z.5    Liu, W.6    Xu, J.7
  • 35
    • 79955430184 scopus 로고    scopus 로고
    • Effect of chitosan chain architecture on gene delivery: Comparison of self-branched and linear chitosans
    • J. Malmo, K.M. Varum, and S.P. Strand Effect of chitosan chain architecture on gene delivery: comparison of self-branched and linear chitosans Biomacromolecules 12 2011 721 729
    • (2011) Biomacromolecules , vol.12 , pp. 721-729
    • Malmo, J.1    Varum, K.M.2    Strand, S.P.3
  • 36
    • 83655166996 scopus 로고    scopus 로고
    • Chitosan-based therapeutic nanoparticles for combination gene therapy and gene silencing of in vitro cell lines relevant to type 2 diabetes
    • M. Jean, M. Alameh, J.D. De, M. Thibault, M. Lavertu, V. Darras, M. Nelea, M.D. Buschmann, and A. Merzouki Chitosan-based therapeutic nanoparticles for combination gene therapy and gene silencing of in vitro cell lines relevant to type 2 diabetes Eur. J. Pharm. Sci. 45 2012 138 149
    • (2012) Eur. J. Pharm. Sci. , vol.45 , pp. 138-149
    • Jean, M.1    Alameh, M.2    De, J.D.3    Thibault, M.4    Lavertu, M.5    Darras, V.6    Nelea, M.7    Buschmann, M.D.8    Merzouki, A.9
  • 37
    • 58149215702 scopus 로고    scopus 로고
    • Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    • K.A. Howard, S.R. Paludan, M.A. Behlke, F. Besenbacher, B. Deleuran, and J. Kjems Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model Mol. Ther. 17 2009 162 168
    • (2009) Mol. Ther. , vol.17 , pp. 162-168
    • Howard, K.A.1    Paludan, S.R.2    Behlke, M.A.3    Besenbacher, F.4    Deleuran, B.5    Kjems, J.6
  • 42
    • 84871663410 scopus 로고    scopus 로고
    • Chitosan-hyaluronic acid nanoparticles for gene silencing: The role of hyaluronic acid on the nanoparticles' formation and activity
    • S. Al-Qadi, M. Alatorre-Meda, E.M. Zaghloul, P. Taboada, and C. Remunan-Lopez Chitosan-hyaluronic acid nanoparticles for gene silencing: the role of hyaluronic acid on the nanoparticles' formation and activity Colloids Surf. B Biointerfaces 103C 2012 615 623
    • (2012) Colloids Surf. B Biointerfaces , vol.103 C , pp. 615-623
    • Al-Qadi, S.1    Alatorre-Meda, M.2    Zaghloul, E.M.3    Taboada, P.4    Remunan-Lopez, C.5
  • 43
    • 84870307914 scopus 로고    scopus 로고
    • Synthesis of TAT peptide-tagged PEGylated chitosan nanoparticles for siRNA delivery targeting neurodegenerative diseases
    • M. Malhotra, C. Tomaro-Duchesneau, and S. Prakash Synthesis of TAT peptide-tagged PEGylated chitosan nanoparticles for siRNA delivery targeting neurodegenerative diseases Biomaterials 34 2013 1270 1280
    • (2013) Biomaterials , vol.34 , pp. 1270-1280
    • Malhotra, M.1    Tomaro-Duchesneau, C.2    Prakash, S.3
  • 44
    • 77957298626 scopus 로고    scopus 로고
    • Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly(gamma-glutamic acid)
    • Z.X. Liao, Y.C. Ho, H.L. Chen, S.F. Peng, C.W. Hsiao, and H.W. Sung Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly(gamma-glutamic acid) Biomaterials 31 2010 8780 8788
    • (2010) Biomaterials , vol.31 , pp. 8780-8788
    • Liao, Z.X.1    Ho, Y.C.2    Chen, H.L.3    Peng, S.F.4    Hsiao, C.W.5    Sung, H.W.6
  • 45
    • 69949128210 scopus 로고    scopus 로고
    • Preparation and characterization of chitosan/polyguluronate nanoparticles for siRNA delivery
    • D.W. Lee, K.S. Yun, H.S. Ban, W. Choe, S.K. Lee, and K.Y. Lee Preparation and characterization of chitosan/polyguluronate nanoparticles for siRNA delivery J. Control. Release 139 2009 146 152
    • (2009) J. Control. Release , vol.139 , pp. 146-152
    • Lee, D.W.1    Yun, K.S.2    Ban, H.S.3    Choe, W.4    Lee, S.K.5    Lee, K.Y.6
  • 47
    • 80052367899 scopus 로고    scopus 로고
    • Chitosan-graft-(PEI-beta-cyclodextrin) copolymers and their supramolecular PEGylation for DNA and siRNA delivery
    • Y. Ping, C. Liu, Z. Zhang, K.L. Liu, J. Chen, and J. Li Chitosan-graft-(PEI-beta-cyclodextrin) copolymers and their supramolecular PEGylation for DNA and siRNA delivery Biomaterials 32 2011 8328 8341
    • (2011) Biomaterials , vol.32 , pp. 8328-8341
    • Ping, Y.1    Liu, C.2    Zhang, Z.3    Liu, K.L.4    Chen, J.5    Li, J.6
  • 49
    • 73249126217 scopus 로고    scopus 로고
    • Development of pH-responsive nanocarriers using trimethylchitosans and methacrylic acid copolymer for siRNA delivery
    • V. Dehousse, N. Garbacki, A. Colige, and B. Evrard Development of pH-responsive nanocarriers using trimethylchitosans and methacrylic acid copolymer for siRNA delivery Biomaterials 31 2010 1839 1849
    • (2010) Biomaterials , vol.31 , pp. 1839-1849
    • Dehousse, V.1    Garbacki, N.2    Colige, A.3    Evrard, B.4
  • 50
    • 84876464768 scopus 로고    scopus 로고
    • Ternary polymeric nanoparticles for oral siRNA delivery
    • J. Zhang, C. He, C. Tang, and C. Yin Ternary polymeric nanoparticles for oral siRNA delivery Pharm. Res. 30 2013 1228 1239
    • (2013) Pharm. Res. , vol.30 , pp. 1228-1239
    • Zhang, J.1    He, C.2    Tang, C.3    Yin, C.4
  • 55
    • 70349492117 scopus 로고    scopus 로고
    • Hyaluronic acid complexed to biodegradable poly l-arginine for targeted delivery of siRNAs
    • E.J. Kim, G. Shim, K. Kim, I.C. Kwon, Y.K. Oh, and C.K. Shim Hyaluronic acid complexed to biodegradable poly l-arginine for targeted delivery of siRNAs J. Gene Med. 11 2009 791 803
    • (2009) J. Gene Med. , vol.11 , pp. 791-803
    • Kim, E.J.1    Shim, G.2    Kim, K.3    Kwon, I.C.4    Oh, Y.K.5    Shim, C.K.6
  • 56
    • 67651202350 scopus 로고    scopus 로고
    • Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
    • O.M. Merkel, D. Librizzi, A. Pfestroff, T. Schurrat, K. Buyens, N.N. Sanders, S.C. De Smedt, M. Behe, and T. Kissel Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging J. Control. Release 138 2009 148 159
    • (2009) J. Control. Release , vol.138 , pp. 148-159
    • Merkel, O.M.1    Librizzi, D.2    Pfestroff, A.3    Schurrat, T.4    Buyens, K.5    Sanders, N.N.6    De Smedt, S.C.7    Behe, M.8    Kissel, T.9
  • 57
    • 78650342641 scopus 로고    scopus 로고
    • Chitosan mediated targeted drug delivery system: A review
    • M.P. Patel, R.R. Patel, and J.K. Patel Chitosan mediated targeted drug delivery system: a review J. Pharm. Pharm. Sci. 13 2010 536 557
    • (2010) J. Pharm. Pharm. Sci. , vol.13 , pp. 536-557
    • Patel, M.P.1    Patel, R.R.2    Patel, J.K.3
  • 58
    • 79959872019 scopus 로고    scopus 로고
    • Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles
    • P.M. Valencia, M.H. Hanewich-Hollatz, W. Gao, F. Karim, R. Langer, R. Karnik, and O.C. Farokhzad Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles Biomaterials 32 2011 6226 6233
    • (2011) Biomaterials , vol.32 , pp. 6226-6233
    • Valencia, P.M.1    Hanewich-Hollatz, M.H.2    Gao, W.3    Karim, F.4    Langer, R.5    Karnik, R.6    Farokhzad, O.C.7
  • 59
    • 84868563717 scopus 로고    scopus 로고
    • RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis
    • F. Danhier, B.A. Le, and V. Preat RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis Mol. Pharm. 9 2012 2961 2973
    • (2012) Mol. Pharm. , vol.9 , pp. 2961-2973
    • Danhier, F.1    Le, B.A.2    Preat, V.3
  • 60
    • 41449098351 scopus 로고    scopus 로고
    • Targeted drug delivery via folate receptors
    • DOI 10.1517/17425247.5.3.309
    • X. Zhao, H. Li, and R.J. Lee Targeted drug delivery via folate receptors Expert Opin. Drug Deliv. 5 2008 309 319 (Pubitemid 351454380)
    • (2008) Expert Opinion on Drug Delivery , vol.5 , Issue.3 , pp. 309-319
    • Zhao, X.1    Li, H.2    Lee, R.J.3
  • 61
    • 70849097385 scopus 로고    scopus 로고
    • Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy
    • K. Buyens, M. Meyer, E. Wagner, J. Demeester, S.C. De Smedt, and N.N. Sanders Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy J. Control. Release 141 2010 38 41
    • (2010) J. Control. Release , vol.141 , pp. 38-41
    • Buyens, K.1    Meyer, M.2    Wagner, E.3    Demeester, J.4    De Smedt, S.C.5    Sanders, N.N.6
  • 62
    • 83255185737 scopus 로고    scopus 로고
    • Special delivery: Targeted therapy with small RNAs
    • D. Peer, and J. Lieberman Special delivery: targeted therapy with small RNAs Gene Ther. 18 2011 1127 1133
    • (2011) Gene Ther. , vol.18 , pp. 1127-1133
    • Peer, D.1    Lieberman, J.2
  • 63
    • 80052627990 scopus 로고    scopus 로고
    • Current progress of siRNA/shRNA therapeutics in clinical trials
    • J.C. Burnett, J.J. Rossi, and K. Tiemann Current progress of siRNA/shRNA therapeutics in clinical trials Biotechnol. J. 6 2011 1130 1146
    • (2011) Biotechnol. J. , vol.6 , pp. 1130-1146
    • Burnett, J.C.1    Rossi, J.J.2    Tiemann, K.3
  • 64
    • 84857198814 scopus 로고    scopus 로고
    • Local delivery of chitosan/VEGF siRNA nanoplexes reduces angiogenesis and growth of breast cancer in vivo
    • E. Salva, L. Kabasakal, F. Eren, N. Ozkan, F. Cakalagaoglu, and J. Akbuga Local delivery of chitosan/VEGF siRNA nanoplexes reduces angiogenesis and growth of breast cancer in vivo Nucleic Acid Ther. 22 2012 40 48
    • (2012) Nucleic Acid Ther. , vol.22 , pp. 40-48
    • Salva, E.1    Kabasakal, L.2    Eren, F.3    Ozkan, N.4    Cakalagaoglu, F.5    Akbuga, J.6
  • 67
    • 77957858210 scopus 로고    scopus 로고
    • Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFalpha prevents radiation-induced fibrosis
    • I. Nawroth, J. Alsner, M.A. Behlke, F. Besenbacher, J. Overgaard, K.A. Howard, and J. Kjems Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFalpha prevents radiation-induced fibrosis Radiother. Oncol. 97 2010 143 148
    • (2010) Radiother. Oncol. , vol.97 , pp. 143-148
    • Nawroth, I.1    Alsner, J.2    Behlke, M.A.3    Besenbacher, F.4    Overgaard, J.5    Howard, K.A.6    Kjems, J.7
  • 68
  • 70
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • DOI 10.1016/j.ijpharm.2005.10.010, PII S037851730500668X
    • D.E. Owens III, and N.A. Peppas Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int. J. Pharm. 307 2006 93 102 (Pubitemid 41773257)
    • (2006) International Journal of Pharmaceutics , vol.307 , Issue.1 , pp. 93-102
    • Owens III, D.E.1    Peppas, N.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.