Activation of autophagic flux against xenoestrogen bisphenol-A-induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of rapamycin (mTOR) pathways

Journal of Biological Chemistry

Volumn 290, Issue 34, 2015, Pages 21163-21184

  Agarwal, Swati ^a,b   Tiwari, Shashi Kant ^a,b   Seth, Brashket ^a,b   Yadav, Anuradha ^a,b   Singh, Anshuman ^a   Mudawal, Anubha ^a,b   Chauhan, Lalit Kumar Singh ^c   Gupta, Shailendra Kumar ^b,f   Choubey, Vinay ^d   Tripathi, Anurag ^b,e   Kumar, Amit ^a,b   Ray, Ratan Singh ^b,f   Shukla, Shubha ^g   Parmar, Devendra ^a,b   Chaturvedi, Rajnish Kumar ^a,b  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c Central Instrumentation Facility   (India)

^d Faculty of Medicine   (Estonia)

^e Food   (India)

^f Systems Toxicology and Health Risk Assessment Group   (India)

^g CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; ENZYMES; GENE EXPRESSION; HEALTH HAZARDS; MAMMALS; PHENOLS; PHOSPHORYLATION; STEM CELLS;

ACETYL-COA CARBOXYLASE; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MITOCHONDRIAL TRANSLOCATION; MOLECULAR MECHANISM; NEURODEGENERATION; PHARMACOLOGICAL ACTIVATOR; REACTIVE OXYGEN SPECIES; TARGET OF RAPAMYCIN;

ANTIBIOTICS;

4,4' ISOPROPYLIDENEDIPHENOL; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; BECLIN 1; CASPASE 3; CELL PROTEIN; HEAT SHOCK COGNATE PROTEIN 60; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK COGNATE PROTEIN 71; HEAT SHOCK PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; LC3 II PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MALONALDEHYDE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PARKIN; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; S6 KINASE; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; WORTMANNIN; AMP-ACTIVATED PROTEIN KINASE KINASE; ANDROSTANE DERIVATIVE; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, RAT; BENZHYDRYL DERIVATIVE; LC3 PROTEIN, RAT; MACROLIDE; MICROTUBULE ASSOCIATED PROTEIN; MTOR PROTEIN, RAT; PHENOL DERIVATIVE; POLLUTANT; PROTEIN KINASE; SQSTM1 PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATG12 GENE; ATG3 GENE; ATG5 GENE; AUTOPHAGY; BECLIN 1 GENE; BIOENERGY; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; HIPPOCAMPUS; HMGB1 GENE; IN VITRO STUDY; LAMP 2 GENE; LC3 GENE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL LOSS; MITOPHAGY; MOLECULAR DYNAMICS; NERVE DEGENERATION; NEURAL STEM CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARK2 GENE; PARKIN GENE; PINK1 GENE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEOMICS; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NERVE CELL; NEWBORN; PATHOLOGY; POLLUTANT; PRIMARY CELL CULTURE; TOXICITY; WISTAR RAT;

MAMMALIA; RAPTORES;

ANDROSTADIENES; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BENZHYDRYL COMPOUNDS; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HIPPOCAMPUS; HUMANS; MACROLIDES; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; OXIDATIVE STRESS; PHENOLS; PRIMARY CELL CULTURE; PROTEIN KINASES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84939838851     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.648998     Document Type: Article

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