TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Pla, A ^a   Pascual, M ^a   Renau Piqueras, J ^b   Guerri, C ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

autophagy lysosome pathway; brain damage; ethanol; TLR4; ubiquitin proteasome pathway

Indexed keywords

ALCOHOL; AUTOPHAGY PROTEIN 5; CATHEPSIN B; MAMMALIAN TARGET OF RAPAMYCIN; PROTEASOME; PROTEASOME 20S; PROTEASOME ALPHA2; PROTEASOME BETA5; PROTEIN; PROTEIN ATG12; PROTEIN BETA2I; PROTEIN BETA5I; PROTEIN LC3; PROTEIN P62; PROTEIN PA28 ALPHA; TOLL LIKE RECEPTOR 4; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN CORTEX; BRAIN DAMAGE; CELL VACUOLE; CONTROLLED STUDY; GLIA; KNOCKOUT MOUSE; LYSOSOME; MALE; MOLECULAR BIOLOGY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; AUTOPHAGY; CATHEPSIN B; CEREBRAL CORTEX; ETHANOL; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN KINASE INHIBITORS; PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 84896750265     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.46     Document Type: Article

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