Generation of reactive oxygen species in sperms of rats as an earlier marker for evaluating the toxicity of endocrine-disrupting chemicals

Free Radical Research

Volumn 44, Issue 12, 2010, Pages 1398-1406

  Minamiyama, Yukiko ^a,b   Ichikawa, Hiroshi ^c   Takemura, Shigekazu ^d   Kusunoki, Hiroshi ^e   Naito, Yuji ^b   Yoshikawa, Toshikazu ^b  

^a KYOTO PREFECTURAL UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c DOSHISHA UNIVERSITY   (Japan)

^d OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e KOBE UNIVERSITY   (Japan)

Author keywords

biological marker; mitochondria; Sperm toxicity; superoxide; xenobiotic agent

Indexed keywords

4 HYDROXYNONENAL; 4,4' ISOPROPYLIDENEDIPHENOL; ACETYLCYSTEINE; DIETHYLSTILBESTROL; PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PROTEIN MODIFICATION; RAT; REPRODUCTIVE TOXICITY; SPERM; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TOXICITY TESTING;

ANIMALS; BIOLOGICAL MARKERS; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTORS; LIPID PEROXIDATION; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATION-REDUCTION; PHENOLS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; SUPEROXIDES;

RATTUS; RATTUS NORVEGICUS;

EID: 78149278173     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2010.510523     Document Type: Article

References (16)

1. Desai N, Sabanegh E, Jr, Kim T, Agarwal A. Free radical theory of aging: implications in male infertility. Urology 2009; 75:14-19.
2. Shamsi MB, Kumar R, Bhatt A, Bamezai RN, Kumar R, Gupta NP, Das TK, Dada R. Mitochondrial DNA mutations in etiopathogenesis of male infertility. Indian J Urol 2008; 24:150-154.
3. Venkatesh S, Deecaraman M, Kumar R, Shamsi MB, Dada R. Role of reactive oxygen species in the pathogenesis of mito-chondrial DNA (mtDNA) mutations in male infertility. Indian J Med Res 2009;129:127-137.
4. Tremellen K. Oxidative stress and male infertility-a clinical perspective. Hum Reprod Update 2008;14:243-258.
5. Donnelly ET, McClure N, Lewis SE. Glutathione and hypotaurine in vitro : effects on human sperm motility, DNA integrity and production of reactive oxygen species. Mutagen-esis 2000;15:61-68.
6. Akingbemi BT, Sottas CM, Koulova AI, Klinefelter GR, Hardy M P. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 2004;145:592-603.
7. Adachi T, Sakurai K, Fukata H, Komiyama M, Shibayama T, Iguchi T, Mori C. A DNA microarray analysis for the effect of spermatogenesis to phytoestrogen and endocrine disrup-tors in mice. Chiba Medicine 2001;77:151-158.
8. Gill WB, Schumacher GF, Bibbo M. Structural and functional abnormalities in the sex organs of male offspring of mothers treated with diethylstilbestrol (DES). J Reprod Med 1976;16:147-153.
9. Isobe T. Assesment of fertility by sperm mechanical energy using computer-assisted sperm analysis system. Reprod Med Biol 2009;8:25-31.
10. Imada I, Sato EF, Miyamoto M, Ichimori Y, Minamiyama Y, Konaka R, Inoue M. Analysis of reactive oxygen species generated by neutrophils using a chemiluminescence probe L-012. Anal Biochem 1999;271:53-58.
11. Minamiyama Y, Bito Y, Takemura S, Takahashi Y, Kodai S, Mizuguchi S, Nishikawa Y, Suehiro S, Okada S. Calorie restriction improves cardiovascular risk factors via reduction of mito chondrial reactive oxygen species in type II diabetic rats. J Pharmacol Exp Ther 2007;320:535-543.
12. Tunc O, Thompson J, Tremellen K. Improvement in sperm DNA quality using an oral antioxidant therapy. Reprod Biomed Online 2009;18:761-768.
13. Conte G, Milardi D, De Marinis L, Mancini A. Reactive oxygen species in male infertility. Review of literature and personal observations. Panminerva Med 1999;41:45-53.
14. Ford WC. Regulation of sperm function by reactive oxygen species. Hum Reprod Update 2004;10:387-399.
15. Kumar R, Venkatesh S, Kumar M, Tanwar M, Shasmsi MB, Kumar R, Gupta NP, Sharma RK, Talwar P, Dada R. Oxida-tive stress and sperm mitochondrial DNA mutation in idio-pathic oligoasthenozoospermic men. Indian J Biochem Biophys 2009;46:172-177.
16. Franca LR, Ogawa T, Avarbock MR, Brinster RL, Russell LD. Germ cell genotype controls cell cycle during spermatogenesis in the rat. Biol Reprod 1998;59:1371-1377.