Selective whole-cell biosynthesis of the designer drug metabolites 15- or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants

Journal of Molecular Catalysis B: Enzymatic

Volumn 121, Issue , 2015, Pages 64-74

  Reinen, Jelle ^a   Vredenburg, Galvin ^a   Klaering, Karoline ^a   Vermeulen, Nico P E ^a   Commandeur, Jan N M ^a   Honing, Maarten ^a   Vos, J Chris ^a  

^a AMSTERDAM INSTITUTE FOR MOLECULES   (Netherlands)

Author keywords

Biotechnology; Cytochrome P450 BM3; Norethisterone; Stereo and regioselectivity; Whole cell biocatalysis

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; BIOTECHNOLOGY; COST EFFECTIVENESS; CYTOLOGY; ESCHERICHIA COLI; FERMENTERS; HYDROXYLATION; STEREOSELECTIVITY; YEAST;

CYTOCHROME P450 BM3; MUTANT LIBRARIES; NORETHISTERONE; OXIDATION SYSTEMS; RESTING AND GROWING CELLS; STEREOSELECTIVE HYDROXYLATIONS; WHOLE-CELL BIOCATALYSIS; WHOLE-CELL BIOTRANSFORMATIONS;

CELLS;

15BETA HYDROXYNORETHISTERONE; 16BETA HYDROXYNORETHISTERONE; CYTOCHROME P450 BM3; DRUG METABOLITE; NORETHISTERONE; UNCLASSIFIED DRUG;

ARTICLE; BIOREACTOR; BIOSYNTHESIS; DRUG HYDROXYLATION; DRUG TRANSFORMATION; ESCHERICHIA COLI; OXIDATION; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; STEREOCHEMISTRY; STEROID HYDROXYLATION; WHOLE CELL;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

EID: 84939799920     PISSN: 13811177     EISSN: 18733158     Source Type: Journal    
DOI: 10.1016/j.molcatb.2015.08.003     Document Type: Article

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