Convenient gram-scale metabolite synthesis by engineered fission yeast strains expressing functional human P450 systems

Applied Biochemistry and Biotechnology

Volumn 163, Issue 8, 2011, Pages 965-980

  Drǎgan, Cǎlin Aurel ^a   Peters, Frank T ^b   Bour, Pierre ^a   Schwaninger, Andrea E ^b   Schaan, Stefanie M ^b   Neunzig, Ina ^a   Widjaja, Maria ^a   Zapp, Josef ^a   Kraemer, Thomas ^b   Maurer, Hans H ^b   Bureik, Matthias ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

CYP; Cytochrome P450; Diclofenac; Fission yeast; Hydroxydiclofenac; Phase 1 metabolism; Schizosaccharomyces pombe

Indexed keywords

CYP; CYTOCHROME P450; DICLOFENAC; FISSION YEAST; HYDROXYDICLOFENAC; PHASE 1 METABOLISM; SCHIZOSACCHAROMYCES POMBE;

ANIMALS; BIOCONVERSION; BIOMOLECULES; GLUCOSE; METABOLISM; METABOLITES; PHYSIOLOGY; STRAIN; SYNTHESIS (CHEMICAL);

YEAST;

CYTOCHROME P450 REDUCTASE; GLUCOSE;

ARTICLE; COST BENEFIT ANALYSIS; IN VITRO STUDY; INCUBATION TIME; NONHUMAN; PH MEASUREMENT; PROTEIN SYNTHESIS; SCHIZOSACCHAROMYCES POMBE; TEMPERATURE SENSITIVITY;

CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION; GENE EXPRESSION REGULATION, FUNGAL; GENETIC ENGINEERING; HUMANS; ISOENZYMES; SCHIZOSACCHAROMYCES;

ANIMALIA; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 79952694528     PISSN: 02732289     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12010-010-9100-3     Document Type: Article

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