Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 7-8, 2010, Pages 667-674

  de Vlieger, Jon S B ^a   Kolkman, Ard J ^b   Ampt, Kirsten A M ^b   Commandeur, Jan N M ^a   Vermeulen, Nico P E ^a   Kool, Jeroen ^a   Wijmenga, Sybren S ^b   Niessen, Wilfried M A ^a   Irth, Hubertus ^a   Honing, Maarten ^c  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bioaffinity; Biosynthetic enzymes; High resolution mass spectrometry; High resolution screening; Human estrogen receptor; Hyphenation; Liquid chromatography mass spectrometry; Nuclear magnetic resonance spectroscopy

Indexed keywords

BIOAFFINITY; BIOSYNTHETIC ENZYMES; HIGH RESOLUTION MASS SPECTROMETRY; HIGH RESOLUTION SCREENING; HUMAN ESTROGEN RECEPTORS; HYPHENATION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY;

ASSAYS; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSTS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ENZYMES; LIGANDS; LIQUIDS; MAGNETIC RESONANCE SPECTROMETERS; MASS SPECTROMETERS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE DETECTORS; RESONANCE;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

CYTOCHROME P450; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; NORETHISTERONE;

ARTICLE; BIOTRANSFORMATION; ENZYME SYNTHESIS; ESTROGEN SYNTHESIS; LIGAND BINDING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; RECEPTOR AFFINITY;

BIOREACTORS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DISCOVERY; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; ETHINYL ESTRADIOL; HUMANS; MASS SPECTROMETRY; NORETHINDRONE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 76549089021     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.01.035     Document Type: Article

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