Food specific oral immunotherapy: A potential treatment for food allergy

Expert Review of Gastroenterology and Hepatology

Volumn 9, Issue 9, 2015, Pages 1147-1159

  Burbank, Allison J ^a   Burks, Wesley ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Desensitization; Double blind placebo controlled food challenge; Food allergy; Omalizumab; Oral immunotherapy; Probiotic; Sustained unresponsiveness; Tolerance

Indexed keywords

ADRENALIN; CD4 ANTIGEN; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN G4 ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ABDOMINAL DISEASE; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTIGEN SPECIFICITY; CLINICAL EFFECTIVENESS; CLINICAL PROTOCOL; CLINICAL TRIAL (TOPIC); CLONAL ANERGY; CYTOKINE PRODUCTION; DENDRITIC CELL; DESENSITIZATION; EGG ALLERGY; EOSINOPHILIC ESOPHAGITIS; FISH ALLERGY; FOOD ALLERGY; FOOD INTAKE; HUMAN; IMMUNOLOGICAL TOLERANCE; LYMPHOID TISSUE; MILK ALLERGY; MOLECULAR DYNAMICS; MUCOSAL ASSOCIATED LYMPHOID TISSUE; NONHUMAN; ORAL IMMUNOTHERAPY; OUTCOME ASSESSMENT; PATIENT SAFETY; PEANUT ALLERGY; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT DISEASE; REVIEW; SHELLFISH ALLERGY; SOY ALLERGY; TH2 CELL; WHEAT ALLERGY; FOOD HYPERSENSITIVITY; IMMUNOLOGY; ORAL DRUG ADMINISTRATION; PROCEDURES; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; DESENSITIZATION, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; HUMANS; IMMUNE TOLERANCE; TREATMENT OUTCOME;

EID: 84939788212     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/17474124.2015.1065177     Document Type: Review

References (88)

1. Gupta RS, Springston EE, Warrier MR, et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics 2011;128(1):e9-17
2. Chafen JJ, Newberry SJ, Riedl MA, et al. Diagnosing and managing common food allergies: a systematic review. JAMA 2010; 303(18):1848-56
3. Varshney P, Jones SM, Scurlock AM, et al. A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol 2011;127(3): 654-60.
4. Soller L, Ben-Shoshan M, Harrington DW, et al. Adjusting for nonresponse bias corrects overestimates of food allergy prevalence. J Allergy Clin Immunol Pract 2015;3(2):291-293 e2
5. Osborne NJ, Koplin JJ, Martin PE, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol 2011;127(3):668-76
6. Eggesbo M, Botten G, Halvorsen R, Magnus P. The prevalence of CMA/CMPI in young children: the validity of parentally perceived reactions in a population-based study. Allergy 2001;56(5):393-402
7. Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy 1990; 45(8):587-96
8. Eggesbo M, Botten G, Halvorsen R, Magnus P. The prevalence of allergy to egg: a population-based study in young children. Allergy 2001;56(5):403-11
9. Kim J, Kwon J, Noh G, Lee SS. The effects of elimination diet on nutritional status in subjects with atopic dermatitis. Nutr Res Pract 2013;7(6):488-94
10. Hobbs CB, Skinner AC, Burks AW, Vickery BP. Food allergies affect growth in children. J Allergy Clin Immunol Pract 2015;3(1):133; 4 e1
11. Turner PJ, Gowland MH, Sharma V, et al. Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data 1992-2012. J Allergy Clin Immunol 2015;135(4):956-63 e1
12. Nowak-Wegrzyn A, Sampson HA. Future therapies for food allergies. J Allergy Clin Immunol 2011;127(3):558-73; quiz 574-5
13. Nurmatov U, Venderbosch I, Devereux G, et al. Allergen-specific oral immunotherapy for peanut allergy. Cochrane Database Syst Rev 2012;9:CD009014
14. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol 2010; 125(2 Suppl 2):S116-25
15. Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol 2007;119(4):1016-18
16. Wensing M, Penninks AH, Hefle SL, et al. The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind, placebo-controlled food challenges. Clin Exp Allergy 2002;32(12): 1757-62
17. Nguyen-Luu NU, Ben-Shoshan M, Alizadehfar R, et al. Inadvertent exposures in children with peanut allergy. Pediatr Allergy Immunol 2012;23(2):133-9
18. Sampson MA, Munoz-Furlong A, Sicherer SH. Risk-taking and coping strategies of adolescents and young adults with food allergy. J Allergy Clin Immunol 2006;117(6):1440-5
19. Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001;107(1): 191-3
20. Lieberman JA, Sicherer SH. Quality of life in food allergy. Curr Opin Allergy Clin Immunol 2011;11(3):236-42
21. Sicherer SH, Munõz-Furlong A, Godbold JH, Sampson HA. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol 2010;125(6):1322-6
22. Vickery BP, Scurlock AM, Jones SM, Burks AW. Mechanisms of immune tolerance relevant to food allergy. J Allergy Clin Immunol 2011;127(3):576-84; quiz 585-6
23. Faria AM, Weiner HL. Oral tolerance. Immunol Rev 2005;206:232-59
24. Vickery BP, Burks AW. Immunotherapy in the treatment of food allergy: focus on oral tolerance. Curr Opin Allergy Clin Immunol 2009;9(4):364-70
25. Chehade M, Mayer L. Oral tolerance and its relation to food hypersensitivities. J Allergy Clin Immunol 2005;115(1):3-12; quiz 13
26. Michael JG. The role of digestive enzymes in orally induced immune tolerance. Immunol Invest 1989;18(9-10):1049-54
27. Friedman A, Weiner HL. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci USA 1994;91(14): 6688-92
28. Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003;3(4):331-41
29. Vickery BP, Lin J, Kulis M, et al. Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens. J Allergy Clin Immunol 2013;131(1): 128-34
30. Gorelik M, Narisety SD, Guerrerio AL, et al. Suppression of the immunologic response to peanut during immunotherapy is often transient. J Allergy Clin Immunol 2015;135(5):1283-92
31. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009;124(2):292-300.
32. Syed A, Garcia MA, Lyu SC, et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol 2014;133(2):500-10
33. Chen Y, Inobe J, Marks R, et al. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 1995;376(6536):177-80
34. Oppenheimer JJ, Nelson HS, Bock SA, et al. Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol 1992;90(2):256-62
35. Nelson HS, Lahr J, Rule R, et al. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol 1997;99(6 Pt 1):744-51
36. Hofmann AM, Scurlock AM, Jones SM, et al. Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol 2009;124(2):286-91
37. Kulis M, Wright BL, Jones SM, Burks AW. Diagnosis, management, and investigational therapies for food allergies. Gastroenterology 2015;148(6):1132-42
38. Vickery BP, Scurlock AM, Kulis M, et al. Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy. J Allergy Clin Immunol 2014;133(2):468-75
39. Moran TP, Vickery BP, Burks AW. Oral and sublingual immunotherapy for food allergy: Current progress and future directions. Curr Opin Immunol 2013;25(6): 781-7
40. Staden U, Rolinck-Werninghaus C, Brewe F, et al. Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007;62(11):1261-9
41. Longo G, Barbi E, Berti I, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008;121(2):343-7
42. Zapatero L, Alonso E, Fuentes V, Martnez MI. Oral desensitization in children with cow's milk allergy. J Investig Allergol Clin Immunol 2008;18(5):389-96
43. Skripak JM, Nash SD, Rowley H, et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2008;122(6): 1154-60.
44. Narisety SD, Skripak JM, Steele P, et al. Open-label maintenance after milk oral immunotherapy for IgE-mediated cow's milk allergy. J Allergy Clin Immunol 2009; 124(3):610-12
45. Salmivesi S, Korppi M, Mäkelä MJ, Paassilta M. Milk oral immunotherapy is effective in school-aged children. Acta Paediatr 2013;102(2):172-6
46. Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, et al. The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol 2012; 129(2):448-55.
47. Keet CA, Seopaul S, Knorr S, et al. Long-term follow-up of oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2013;132(3): 737-739 e6
48. Buchanan AD, Green TD, Jones SM, et al. Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 2007;119(1):199-205
49. Itoh N, Itagaki Y, Kurihara K. Rush specific oral tolerance induction in school-age children with severe egg allergy: one year follow up. Allergol Int 2010;59(1):43-51
50. Garcia Rodriguez R, Urra JM, Feo-Brito F, et al. Oral rush desensitization to egg: efficacy and safety. Clin Exp Allergy 2011; 41(9):1289-96
51. Meglio P, Giampietro PG, Carello R, et al. Oral food desensitization in children with IgE-mediated hen's egg allergy: a new protocol with raw hen's egg. Pediatr Allergy Immunol 2013;24(1):75-83
52. Dello Iacono I, Tripodi S, Calvani M, et al. Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: a randomized controlled trial. Pediatr Allergy Immunol 2013;24(1):66-74
53. Burks AW, Jones SM, Wood RA, et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med 2012; 367(3):233-43.
54. Caminiti L, Pajno GB, Crisafulli G, et al. Oral immunotherapy for egg allergy: A double-blind placebo-controlled study, with postdesensitization follow-up. J Allergy Clin Immunol Pract 2015. [Epub ahead of print]
55. Blumchen K, Ulbricht H, Staden U, et al. Oral peanut immunotherapy in children with peanut anaphylaxis. J Allergy Clin Immunol 2010;126(1):83-91
56. Anagnostou K, Islam S, King Y, et al. Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. Lancet 2014;383(9925):1297-304
57. Begin P, Winterroth LC, Dominguez T, et al. Safety and feasibility of oral immunotherapy to multiple allergens for food allergy. Allergy Asthma Clin Immunol 2014;10(1):1
58. Calatayud CM, Garc?á AM, Aragones AM, Caballer Bde L. Safety and efficacy profile and immunological changes associated with oral immunotherapy for IgE-mediated cow's milk allergy in children: systematic review and meta-analysis. J Investig Allergol Clin Immunol 2014;24(5):298-307
59. Keet CA, Wood RA. Emerging therapies for food allergy. J Clin Invest 2014;124(5): 1880-6
60. Bird JA, Feldman M, Arneson A, et al. Modified peanut oral immunotherapy protocol safely and effectively induces desensitization. J Allergy Clin Immunol Pract 2015;3(3):433-5
61. Vazquez-Ortiz M, Alvaro M, Piquer M, et al. Baseline specific IgE levels are useful to predict safety of oral immunotherapy in egg-allergic children. Clin Exp Allergy 2014; 44(1):130-41
62. Martinez-Botas J, Rodrguez-Á lvarez M, Cerecedo I, et al. Identification of novel peptide biomarkers to predict safety and efficacy of cow's milk oral immunotherapy by peptide microarray. Clin Exp Allergy 2015;45(6):1071-84
63. Savilahti EM, Kuitunen M, Savilahti E, et al. Specific antibodies in oral immunotherapy for cow's milk allergy: kinetics and prediction of clinical outcome. Int Arch Allergy Immunol 2014;164(1): 32-9
64. Vazquez-Ortiz M, Alvaro-Lozano M, Alsina L, et al. Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test. Clin Exp Allergy 2013;43(1):92-102
65. Varshney P, Steele PH, Vickery BP, et al. Adverse reactions during peanut oral immunotherapy home dosing. J Allergy Clin Immunol 2009;124(6):1351-2
66. Vazquez-Ortiz M, Alvaro M, Piquer M, et al. Life-threatening anaphylaxis to egg and milk oral immunotherapy in asthmatic teenagers. Ann Allergy Asthma Immunol 2014;113(4):482-4
67. Lucendo AJ, Arias A, Tenias JM. Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis. Ann Allergy Asthma Immunol 2014;113(6): 624-9
68. Sanchez-Garcia S, Rodrguez Del R?ó P, Escudero C, et al. Possible eosinophilic esophagitis induced by milk oral immunotherapy. J Allergy Clin Immunol 2012;129(4):1155-7
69. Clayton F, Gysi B, Zenklusen HR, et al. Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE. Gastroenterology 2014;147(3):602-9
70. Huang F, Nowak-Wegrzyn A. Extensively heated milk and egg as oral immunotherapy. Curr Opin Allergy Clin Immunol 2012;12(3):283-92
71. Lieberman JA, Huang FR, Sampson HA, Nowak-We?grzyn A. Outcomes of 100 consecutive open, baked-egg oral food challenges in the allergy office. J Allergy Clin Immunol 2012;129(6):1682-4 e2
72. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, et al. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol 2008; 122(2):342-7
73. Kim JS, Nowak-We?grzyn A, Sicherer SH, et al. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol 2011;128(1): 125-131 e2
74. Lemon-Mule H, Sampson HA, Sicherer SH, et al. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 2008;122(5): 977-83
75. Leonard SA, Sampson HA, Sicherer SH, et al. Dietary baked egg accelerates resolution of egg allergy in children J Allergy Clin Immunol 2012;130(2): 473-80 e1
76. Clark A, Islam S, King Y, et al. A longitudinal study of resolution of allergy to well-cooked and uncooked egg. Clin Exp Allergy 2011;41(5):706-12
77. Jarvinen KM, Beyer K, Vila L, et al. Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy 2007;62(7):758-65
78. Wang J, Lin J, Bardina L, et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol 2010;125(3):695-702
79. Leung DY, Sampson HA, Yunginger JW, et al. Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med 2003; 348(11):986-93
80. Sampson HA, Leung DY, Burks AW, et al. A phase II, randomized, doubleblind, parallelgroup, placebocontrolled oral food challenge trial of Xolair (omalizumab) in peanut allergy. J Allergy Clin Immunol 2011;127(5):1309-10 e1
81. Savage JH, Courneya JP, Sterba PM, et al. Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy. J Allergy Clin Immunol 2012; 130(5):1123-1129 e2
82. Nadeau KC, Schneider LC, Hoyte L, et al. Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol 2011;127(6):1622-4
83. Schneider LC, Rachid R, LeBovidge J, et al. A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients. J Allergy Clin Immunol 2013;132(6):1368-74
84. Begin P, Dominguez T, Wilson SP, et al. Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy Asthma Clin Immunol 2014;10(1):7
85. Tang ML, Ponsonby AL, Orsini F, et al. Administration of a probiotic with peanut oral immunotherapy: A randomized trial. J Allergy Clin Immunol 2015;135(3): 737-744 e8
86. Vazquez-Ortiz M, Alvaro M, Piquer M, et al. Impact of oral immunotherapy on quality of life in egg-allergic children. Pediatr Allergy Immunol 2015;26(3):291-4
87. Factor JM, Mendelson L, Lee J, et al. Effect of oral immunotherapy to peanut on food-specific quality of life. Ann Allergy Asthma Immunol 2012;109(5):348-352 e2
88. Carraro S, Frigo AC, Perin M, et al. Impact of oral immunotherapy on quality of life in children with cow milk allergy: a pilot study. Int J Immunopathol Pharmacol 2012;25(3):793-8