AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Guo, Yuan ^a   Zhang, Yi ^a   Hong, Kai ^a   Luo, Fengyan ^a   Gu, Qiuping ^a   Lu, Nonghua ^a   Bai, Aiping ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CD68 ANTIGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; (6-(4-(2-PIPERIDIN-1-YLETHOXY)PHENYL))-3-PYRIDIN-4-YLPYRAZOLO(1,5-A)PYRIMIDINE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; ANTIDIABETIC AGENT; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RIBONUCLEOTIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA; LIVER INJURY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SURVIVAL RATE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; ENDOTOXEMIA; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; PATHOLOGY; TOXICITY;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DRUG-INDUCED LIVER INJURY; ENDOTOXEMIA; GENE EXPRESSION REGULATION; HYPOGLYCEMIC AGENTS; I-KAPPA B KINASE; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED BALB C; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIMIDINES; REACTIVE OXYGEN SPECIES; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899879628     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086881     Document Type: Article

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