Immunobiology of the Tonsils and Adenoids

Mucosal Immunology: Fourth Edition

Volumn 2-2, Issue , 2015, Pages 1985-2016

  Brandtzaeg, Per ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

B cell homing; Crypt epithelium; Germinal centers; IgD; IgG; Mucosal immunity; Nasopharynx associated lymphoid tissue; Polymeric Ig receptor; Secretory component; Secretory IgA

Indexed keywords

EID: 84939504615     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-415847-4.00103-8     Document Type: Chapter

References (214)

1. Agnello D., Denimal D., Lavaux A., Blondeau-Germe L., Lu B., Gerard N.P., Gerard C., Pothier P. Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine. J. Immunol. 2013, 190:4836-4847.
2. Ahmed R., Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996, 272:54-60.
3. Alinikula J., Lassila O. Gene interaction network regulates plasma cell differentiation. Scand. J. Immunol. 2011, 73:512-519.
4. Alsaleh G., François A., Knapp A.M., Schickel J.N., Sibilia J., Pasquali J.L., Gottenberg J.E., Wachsmann D., Soulas-Sprauel P. Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF. Eur. J. Immunol. 2011, 41:2113-2122.
5. Andersson J., Boasso A., Nilsson J., Zhang R., Shire N.J., Lindback S., Shearer G.M., Chougnet C.A. The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. J. Immunol. 2005, 174:3143-3147.
6. Andrew G.C., Machacek G.F. Pustular bacterids of the hands and feet. Arch. Dermatol. Symphilol. 1935, 32:837-847.
7. Arpin C., de Bouteiller O., Razanajaona D., Fugier-Vivier I., Briere F., Banchereau J., Lebecque S., Liu Y.J. The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cμ-Cδ switch, and λ light chain expression. J. Exp. Med. 1998, 187:1169-1178.
8. Bakke H., Haneberg B. The development of mucosal vaccines. Tidsskr. Nor. Laegeforen 2006, 126:2818-2821. in Norwegian; see. http://www.tidsskriftet.no/.
9. Bakke H., Samdal H.H., Holst J., Oftung F., Haugen I.L., Kristoffersen A.C., Haugan A., Janakova L., Korsvold G.E., Krogh G., Andersen E.A., Djupesland P., Holand T., Rappuoli R., Haneberg B. Oral spray immunization may be an alternative to intranasal vaccine delivery to induce systemic antibodies but not nasal mucosal or cellular immunity. Scand. J. Immunol. 2006, 63:223-231.
10. Belshe R.B., Edwards K.M., Vesikari T., Black S.V., Walker R.E., Hultquist M., Kemble G., Connor E.M. Live attenuated versus inactivated influenza vaccine in infants and young children. N. Engl. J. Med. 2007, 356:685-696. CAIV-T Comparative Efficacy Study Group.
11. Belshe R.B., Gruber W.C., Mendelman P.M., Cho I., Reisinger K., Block S.L., Wittes J., Iacuzio D., Piedra P., Treanor J., King J., KotloffK., Bernstein D.I., Hayden F.G., Zangwill K., Yan L., WolffM. Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine. J. Pediatr. 2000, 136:168-175.
12. Bentebibel S.E., Schmitt N., Banchereau J., Ueno H. Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:E488-E497.
13. Bernstein J.M. The immunobiology of the tonsils and adenoids. Instructional Courses 1990, vol. 3:3-19. Mosby Year Book, St. Louis. J.T. Johnson, A. Blitzer, R. Ossoff, J.R. Thomas (Eds.).
14. Bernstein J.M., Belmont M., Faden H.S., Dryja D., Scannapieco F., Wolf J. Interference of nontypable Haemophilus influenzae and Moraxella catarrhalis by Streptococcus oralis in adenoid organ culture: a possible strategy for the treatment of the otitis-prone child. Ann. Otol. Rhinol. Laryngol. 2002, 111:696-700.
15. Bernstein J.M., Dryja D., Murphy T.F. Molecular typing of paired bacterial isolates from the adenoid and lateral wall of the nose in children undergoing adenoidectomy: implications in acute rhinosinusitis. Otolaryngol. Head Neck Surg. 2000, 125:593-597.
16. Berstad A.K., Andersen S.R., Dalseg R., Dromtorp S., Holst J., Namork E., Wedege E., Haneberg B. Inactivated meningococci and pertussis bacteria are immunogenic and act as mucosal adjuvants for a nasal inactivated influenza virus vaccine. Vaccine 2000, 18:1910-1919.
17. Brambilla I., Pusateri A., Pagella F., Caimmi D., Caimmi S., Licari A., Barberi S., Castellazzi A.M., Marseglia G.L. Adenoids in children: advances in immunology, diagnosis, and surgery. Clin. Anat. 2014, 27:346-352.
18. Brandtzaeg P. Two types of IgA immunocytes in man. Nat. New Biol. 1973, 243:142-143.
19. Brandtzaeg P. Presence of J chain in human immunocytes containing various immunoglobulin classes. Nature 1974, 252:418-420.
20. Brandtzaeg P. Immunohistochemical characterization of intracellular J-chain and binding site for secretory component (SC) in human immunoglobulin (Ig)-producing cells. Mol. Immunol. 1983, 20:941-966.
21. Brandtzaeg P. Immune functions of human nasal mucosa in tonsils in health and disease. Immunobiology of the Lung and Upper Respiratory Tract 1984, 28-95. McGraw-Hill Company, New York. J. Bienenstock (Ed.).
22. Brandtzaeg P. Immune functions and immunopathology of palatine and nasopharyngeal tonsils. Immunology of the Ear 1987, 63-106. Raven Press, New York. J.M. Bernstein, P.L. Ogra (Eds.).
23. Brandtzaeg P. The B cell development in tonsillar lymphoid follicles. Acta Otolaryngol. 1996, 523(S):55-59.
24. Brandtzaeg P. Mucosal immunity in the female genital tract. J. Reprod. Immunol. 1997, 36:23-50.
25. Brandtzaeg P. Immunological functions of adenoids. The Nose 1998, 233-246. Kugler Publications, The Hague. P. van Cauwenberge, D.-Y. Wang, K. Ingels, C. Bachert (Eds.).
26. Brandtzaeg P. Regionalized immune function of tonsils and adenoids. Immunol. Today 1999, 20:383-384.
27. Brandtzaeg P. Induction of secretory immunity and memory at mucosal surfaces. Vaccine 2007, 25:5467-5484.
28. Brandtzaeg P. Mucosal immunity: induction, dissemination, and effector functions. Scand. J. Immunol. 2009, 70:505-515.
29. Brandtzaeg P. Function of mucosa-associated lymphoid tissue in antibody formation. Immunol. Invest. 2010, 39:303-355.
30. Brandtzaeg P. Potential of nasopharynx-associated lymphoid tissue for vaccine responses in the airways. Am. J. Respir. Crit. Care Med. 2011, 183:1595-1604.
31. Brandtzaeg P., Berdal P. J chain in malignant human IgG immunocytes. Scand. J. Immunol. 1975, 4:403-407.
32. Brandtzaeg P., Halstensen T.S. Immunology and immunopathology of tonsils. Adv. Otorhinolaryngol. 1992, 47:64-75.
33. Brandtzaeg P., Johansen F.-E. Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties. Immunol. Rev. 2005, 206:32-63.
34. Brandtzaeg P., Prydz H. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature 1984, 311:71-73.
35. Brandtzaeg P., Farstad I.N., Johansen F.-E., Morton H.C., Norderhaug I.N., Yamanaka T. The B-cell system of human mucosae and exocrine glands. Immunol. Rev. 1999, 171:45-87.
36. Brandtzaeg P., Gjeruldsen S.T., Korsrud F., Baklien K., Berdal P., Ek J. The human secretory immune system shows striking heterogeneity with regard to involvement of J chain-positive IgD immunocytes. J. Immunol. 1979, 122:503-510.
37. Brandtzaeg P., Jahnsen F.L., Farstad I.N., Haraldsen G. Mucosal immunology of the upper airways: an overview. Ann. NY. Acad. Sci. 1997, 830:1-18.
38. Brandtzaeg P., Karlsson G., Hansson G., Petruson B., Bjorkander J., Hanson T.A. The clinical condition of IgA-deficient patients is related to the proportion of IgD- and IgM-producing cells in their nasal mucosa. Clin. Exp. Immunol. 1987, 67:626-636.
39. Brandtzaeg P., Kiyono H., Pabst R., Russell M.W. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol. 2008, 1:31-37.
40. Brandtzaeg P., Surjan L., Berdal P. Immunoglobulin systems of human tonsils I. Control subjects of various ages: quantification of Ig-producing cells, tonsillar morphometry, and serum Ig concentrations. Clin. Exp. Immunol. 1978, 122:503-510.
41. Breitfeld D., Ohl L., Kremmer E., Ellwart J., Sallusto F., Lipp M., Forster R. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 2000, 192:1545-1552.
42. Brokstad K.A., Cox R.J., Olofsson J., Jonsson R., Haaheim L.R. Parenteral influenza vaccination induces a rapid systemic and local immune response. J. Infect. Dis. 1995, 171:198-203.
43. Brokstad K.A., Cox R.J., Eriksson J.C., Olofsson J., Jonsson R., Davidsson A. High prevalence of influenza specific antibody secreting cells in nasal mucosa. Scand. J. Immunol. 2001, 54:243-247.
44. Brokstad K.A., Eriksson J.C., Cox R.J., Tynning T., Olofsson J., Jonsson R., Davidsson A. Parenteral vaccination against influenza does not induce a local antigen-specific immune response in the nasal mucosa. J. Infect. Dis. 2002, 185:878-884.
45. Brook I., Gober A.E. Bacterial interference in the nasopharynx following antimicrobial therapy of acute otitis media. J. Antimicrob. Chemother. 1998, 41:489-492.
46. Bryant V.L., Ma C.S., Avery D.T., Li Y., Good K.L., Corcoran L.M., de Waal Malefyt R., Tangye S.G. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J. Immunol. 2007, 179:8180-8190.
47. Cantani A., Bellioni P., Salvinelli F., Businco L. Serum immunoglobulins and secretory IgA deficiency in tonsillectomized children. Ann. Allergy 1986, 57:413-416.
48. Carlsen H.S., Baekkevold E.S., Johansen F.-E., Haraldsen G., Brandtzaeg P. B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue. Gut 2002, 51:364-371.
49. Carlsen H.S., Baekkevold E.S., Morton H.C., Haraldsen G., Brandtzaeg P. Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Blood 2004, 104:3021-3027.
50. Carlsen H.S., Haraldsen G., Brandtzaeg P., Baekkevold E.S. Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules. Blood 2005, 106:444-446.
51. Casteleyn C., Simoens P., Van den Broeck W. Terminology of the tonsils. Anat. Histol. Embryol. 2011, 40:204-209.
52. Castigli E., Wilson S.A., Scott S., Dedeoglu F., Xu S., Lam K.P., Bram R.J., Jabara H., Geha R.S. TACI and BAFF-R mediate isotype switching in B cells. J. Exp. Med. 2005, 201:35-39.
53. Cella M., Fuchs A., Vermi W., Facchetti F., Otero K., Lennerz J.K., Doherty J.M., Mills J.C., Colonna M. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 2009, 457:722-725.
54. Cha H.R., Ko H.J., Kim E.D., Chang S.Y., Seo S.U., Cuburu N., Ryu S., Kim S., Kweon M.N. Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control. J. Immunol. 2011, 187:3044-3052.
55. Chabot S.M., Chernin T.S., Shawi M., Wagner J., Farrant S., Burt D.S., Cyr S., Neutra M.R. TLR2 activation by proteosomes promotes uptake of particulate vaccines at mucosal surfaces. Vaccine 2007, 25:5348-5358.
56. Chen K., Cerutti A. New insights into the enigma of immunoglobulin D. Immunol. Rev. 2010, 237:160-179.
57. Chen K., Xu W., Wilson M., He B., Miller N.W., Bengtén E., Edholm E.S., Santini P.A., Rath P., Chiu A., Cattalini M., Litzman J., Bussel J.B., Huang B., Meini A., Riesbeck K., Cunningham-Rundles C., Plebani A., Cerutti A. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nat. Immunol. 2009, 10:889-898.
58. Chowdary Venigalla R.K., Guttikonda P.J., Eckstein V., Ho A.D., Sertel S., Lorenz H.M., Tretter T. Identification of a human Th1-like IFNγ-secreting Treg subtype deriving from effector T cells. J. Autoimmun. 2012, 39:377-387.
59. Chu V.T., Beller A., Nguyen T.T., Steinhauser G., Berek C. The long-term survival of plasma cells. Scand. J. Immunol. 2011, 73:508-511.
60. Cuburu N., Kweon M.N., Hervouet C., Cha H.R., Pang Y.Y., Holmgren J., Stadler K., Schiller J.T., Anjuère F., Czerkinsky C. Sublingual immunization with nonreplicating antigens induces antibody-forming cells and cytotoxic T cells in the female genital tract mucosa and protects against genital papillomavirus infection. J. Immunol. 2009, 183:7851-7859.
61. Cupedo T., Crellin N.K., Papazian N., Rombouts E.J., Weijer K., Grogan J.L., Fibbe W.E., Cornelissen J.J., Spits H. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat. Immunol. 2009, 10:66-74.
62. Curran R.C., Jones E.L. Immunoglobulin-containing cells in human tonsils as demonstrated by immunohistochemistry. Clin. Exp. Immunol. 1977, 28:103-115.
63. Czerkinsky C., Cuburu N., Kweon M.N., Anjuere F., Holmgren J. Sublingual vaccination. Hum. Vaccin. 2011, 7:110-114.
64. Czerkinsky C., Holmgren J. Exploration of mucosal immunity in humans: relevance to vaccine development (review). Cell. Mol. Biol. 1994, 1:34-44.
65. Czerkinsky C., Holmgren J. Topical immunization strategies. Mucosal Immunol. 2010, 3:545-555.
66. D'Amelio R., Palmisano L., Le Moli S., Seminara R., Aiuti F. Serum and salivary IgA levels in normal subjects: comparison between tonsillectomized and non-tonsillectomized subjects. Int. Arch. Allergy Appl. Immunol. 1982, 68:256-259.
67. Danilova E., Skrindo I., Gran E., Hales B.J., Smith W.-A., Jahnsen J., Johansen F.-E., Jahnsen F.L., Baekkevold E.S. A role for CCL28-CCR3 in T cell homing to the human upper airway mucosa. Mucosal Immunol. 2014, 8:107-114.
68. Davenport V., Groves E., Hobbs C.G., Williams N.A., Heyderman R.S. Regulation of Th-1 T cell-dominated immunity to Neisseria meningitidis within the human mucosa. Cell. Microbiol. 2007, 9:1050-1061.
69. Debertin A.S., Tschernig T., Tönjes H., Kleemann W.J., Tröger H.D., Pabst R. Nasal-associated lymphoid tissue (NALT): frequency and localization in young children. Clin. Exp. Immunol. 2003, 134:503-507.
70. Devito C., Zuber B., Schröder U., Benthin R., Okuda K., Broliden K., Wahren B., Hinkula J. Intranasal HIV-1-gp160-DNA/gp41 peptide prime-boost immunization regimen in mice results in long-term HIV-1 neutralizing humoral mucosal and systemic immunity. J. Immunol. 2004, 173:7078-7089.
71. Dolen W.K., Spofford B., Selner J.C. The hidden tonsils of Waldeyer's ring. Ann. Allergy 1990, 65:244-250.
72. Dono M., Zupo S., Colombo M., Massara R., Gaidano G., Taborelli G., Ceppa P., Burgio V.L., Chiorazzi N., Ferrarini M. The human marginal zone B cell. Ann. N.Y. Acad. Sci 2003, 987:117-124.
73. Drenth J.P., Goertz J., Daha M.R., van der Meer J.W. Immunoglobulin D enhances the release of tumor necrosis factor-α, and interleukin-1β as well as interleukin-1 receptor antagonist from human mononuclear cells. Immunology 1996, 88:355-362.
74. Dullaers M., Li D., Xue Y., Ni L., Gayet I., Morita R., Ueno H., Palucka K.A., Banchereau J., Oh S. A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts. Immunity 2009, 30:120-129.
75. de Bernardi di Valserra M., Zanasi A., Ragusa S., Glück R., Herzog C. An open-label comparison of the immunogenicity and tolerability of intranasal and intramuscular formulations of virosomal influenza vaccine in healthy adults. Clin. Ther. 2002, 24:100-111.
76. El-Madhun A.S., Cox R.J., Søreide A., Olofsson J., Haaheim L.R. Systemic and mucosal immune responses in young children and adults after parenteral influenza vaccination. J. Infect. Dis. 1998, 178:933-939.
77. Fleige, H., Ravens, S., Moschovakis, G.L., Bölter, J., Willenzon, S., Sutter, G., Häussler, S., Kalinke, U., Prinz, I., Förster, R., 2014. IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J. Exp. Med. 211, 643-651.
78. Fuchs A., Vermi W., Lee J.S., Lonardi S., Gilfillan S., Newberry R.D., Cella M., Colonna M. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12-and IL-15-responsive IFN-γ-producing cells. Immunity 2013, 38:769-781.
79. Fujimura Y. Evidence of M cells as portals of entry for antigens in the nasopharyngeal lymphoid tissue of humans. Virchows Arch. 2000, 436:560-566.
80. Fukuizumi T., Inoue H., Tsujisawa T., Uchiyama C. Streptococcus sobrinus antigens that react to salivary antibodies induced by tonsillar application of formalin-killed S. sobrinus in rabbits. Infect. Immun. 2000, 68:725-731.
81. Fukuyama S., Hiroi T., Yokota Y., Rennert P.D., Yanagita M., Kinoshita N., Terawaki S., Shikina T., Yamamoto M., Kurono Y., Kiyono H. Initiation of NALT organogenesis is independent of the IL-7R, LTβR, and NIK signaling pathways but requires the Id2 gene and CD3-CD4+CD45+ cells. Immunity 2002, 17:31-40.
82. Gallorini S., Taccone M., Bonci A., Nardelli F., Casini D., Bonificio A., Kommareddy S., Bertholet S., O'Hagan D.T., Baudner B.C. Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses. Vaccine 2014, 32:2382-2388.
83. Glezen W.P. Influenza vaccination for healthy children. Curr. Opin. Infect. Dis. 2002, 15:283-287.
84. Greenbaum E., Furst A., Kiderman A., Stewart B., Levy R., Schlesinger M., Morag A., Zakay-Rones Z. Mucosal [SIgA] and serum [IgG] immunologic responses in the community after a single intra-nasal immunization with a new inactivated trivalent influenza vaccine. Vaccine 2002, 20:1232-1239.
85. Hagenaars N., Mania M., de Jong P., Que I., Nieuwland R., Slütter B., Glansbeek H., Heldens J., van den Bosch H., Löwik C., Kaijzel E., Mastrobattista E., Jiskoot W. Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine. J. Control. Release 2010, 144:17-24.
86. Hammerschmidt S.I., Friedrichsen M., Boelter J., Lyszkiewicz M., Kremmer E., Pabst O., Förster R. Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice. J. Clin. Invest. 2011, 121:3051-3061.
87. Heier I., Malmström K., Sajantila A., Lohi J., Mäkelä M., Jahnsen F.L. Characterisation of bronchus-associated lymphoid tissue and antigen-presenting cells in central airway mucosa of children. Thorax 2011, 66:151-156.
88. Henriksson G., Helgeland L., Midtvedt T., Stierna P., Brandtzaeg P. Immune response to Mycoplasma pulmonis in nasal mucosa is modulated by the normal microbiota. Am. J. Respir. Cell Mol. Biol. 2004, 31:657-662.
89. Hess M., Kugler J., Haake D., Lamprecht J. Reduced concentration of secretory IgA indicates changes of local immunity in children with adenoid hyperplasia and secretory otitis media. ORL J. Otorhinolaryngol. Relat. Spec. 1991, 53:339-341.
90. Högerkorp C.M., Borrebaeck C.A. The human CD77- B cell population represents a heterogeneous subset of cells comprising centroblasts, centrocytes, and plasmablasts, prompting phenotypical revision. J. Immunol. 2006, 177:4341-4349.
91. Holmgren J., Czerkinsky C. Mucosal immunity and vaccines. Nat. Med. 2005, 11:S45-S53.
92. Huang C.F., Wu T.C., Chu Y.H., Hwang K.S., Wang C.C., Peng H.J. Effect of neonatal sublingual vaccination with native or denatured ovalbumin and adjuvant CpG or cholera toxin on systemic and mucosal immunity in mice. Scand. J. Immunol. 2008, 68:502-510.
93. Huang H., Peng Y., Liu H., Yang X., Liu F. Decreased CD4+CD25+ cells and increased dimeric IgA-producing cells in tonsils in IgA nephropathy. J. Nephrol. 2010, 23:202-209.
94. Hughes T., Becknell B., McClory S., Briercheck E., Freud A.G., Zhang X., Mao H., Nuovo G., Yu J., Caligiuri M.A. Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22. Blood 2009, 113:4008-4010.
95. Inoue H., Fukuizumi T., Tsujisawa T., Uchiyama C. Simultaneous induction of specific immunoglobulin A-producing cells in major and minor salivary glands after tonsillar application of antigen in rabbits. Oral Microbiol. Immunol. 1999, 14:21-26.
96. Ivarsson M., Quiding-Järbrink M., Lundberg C. Immunoglobulin-secreting cells in the surface secretion on the pharyngeal tonsils. Acta Otolaryngol. 1999, 119:939-943.
97. Jabbal-Gill I. Nasal vaccine innovation. J. Drug. Target. 2010, 18:771-786.
98. Jahnsen F.L., Gran E., Haye R., Brandtzaeg P. Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes. Am. J. Respir. Cell Mol. Biol. 2004, 30:31-37.
99. Janson H., Hedén L.-O., Grubb A., Ruan M., Forsgren A. Protein D, an immunoglobulin D-binding protein of Haemophilus influenzae: cloning, nucleotide sequence, and expression in Escherichia coli. Infect. Immun. 1991, 59:119-125.
100. Jeschke R., Ströder J. Verlaufsbeobachtung klinischer und immunologischer Parameter, insbesondere des Speichel-IgA, bei tonsillektomierten Kindern. Klin. Pädiat. 1980, 192:51-60.
101. Johansen F.-E., Baekkevold E.S., Carlsen H.S., Farstad I.N., Soler D., Brandtzaeg P. Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils. Blood 2005, 106:593-600.
102. Johanson W.G., Blackstock R., Pierce A.K., Sanford J.P. The role of bacterial antagonism in pneumococcal colonization of the human pharynx. J. Lab. Clin. Med. 1970, 75:945-952.
103. Johansson E.L., Rudin A., Wassén L., Holmgren J. Distribution of lymphocytes and adhesion molecules in human cervix and vagina. Immunology 1999, 96:272-277.
104. Johansson E.L., Wassén L., Holmgren J., Jertborn M., Rudin A. Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans. Infect. Immun. 2001, 69:7481-7486.
105. Johnston R.J., Choi Y.S., Diamond J.A., Yang J.A., Crotty S. STAT5 is a potent negative regulator of TFH cell differentiation. J. Exp. Med. 2012, 209:243-250.
106. Junqueira L., Carneiro J. Basic Histology 1980, Lang Medical Publishing, Los Altos, CA.
107. Keitel W.A., Cate T.R., Nino D., Huggins L.L., Six H.R., Quarles J.M., Couch R.B. Immunization against influenza: comparison of various topical and parenteral regimens containing inactivated and/or live attenuated vaccines in healthy adults. J. Infect. Dis. 2001, 183:329-332.
108. Kelsoe G. The germinal center reaction. Immunol. Today 1995, 16:324-326.
109. Kett L., Brandtzaeg P., Radl J., Haaijman J. Different subclass distribution of IgA producing cells in human lymphoid organs and various secretory tissues. J. Immunol. 1986, 136:3631-3635.
110. Kim C.H., Rott L.S., Clark-Lewis I., Campbell D.J., Wu L., Butcher E.C. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J. Exp. Med. 2001, 193:1373-1381.
111. Kim J., Kim Y.M., Jeoung D.I., Choe J. Human follicular dendritic cells promote the APC capability of B cells by enhancing CD86 expression levels. Cell. Immunol. 2012, 273:109-114.
112. Kirstila V., Tenovuo J., Ruuskanen O., Suonpaa J., Meurman O., Vilja P. Longitudinal analysis of human salivary immunoglobulins, nonimmune antimicrobial agents, and microflora after tonsillectomy. Clin. Immunol. Immunopathol. 1996, 80:110-115.
113. Kjeldsen M.K., Perez-Andres M., Schmitz A., Johansen P., Boegsted M., Nyegaard M., Gaihede M., Bukh A., Johnsen H.E., Orfao A., Dybkaer K. Multiparametric flow cytometry for identification and fluorescence activated cell sorting of five distinct B-cell subpopulations in normal tonsil tissue. Am. J. Clin. Pathol. 2011, 136:960-969.
114. Kozlowski P.A., Williams S.B., Lynch R.M., Flanigan T.P., Patterson R.R., Cu-Uvin S., Neutra M.R. Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: influence of the menstrual cycle. J. Immunol. 2002, 169:566-574.
115. Koenecke C., Prinz I., Bubke A., Schreder A., Lee C.W., Pabst O., Förster R. Shift of graft-versus-host-disease target organ tropism by dietary vitamin A. PLoS One 2012, 7:e38252.
116. Korsrud F.R., Brandtzaeg P. Immune systems of human nasopharyngeal and palatine tonsils: histomorphometry of lymphoid components and quantification of immunoglobulin-producing cells in health and disease. Clin. Exp. Immunol. 1980, 39:361-370.
117. Korsrud F.R., Brandtzaeg P. Immunohistochemical evaluation of J-chain expression by intra- and extra-follicular immunoglobulin-producing human tonsillar cells. Scand. J. Immunol. 1981, 13:271-280.
118. Korsrud F.R., Brandtzaeg P. Influence of tonsillar disease on the expression of J chain by immunoglobulin-producing cells in human palatine and nasopharyngeal tonsils. Scand. J. Immunol. 1981, 13:281-287.
119. Kücüksezer U.C., Palomares O., Rückert B., Jartti T., Puhakka T., Nandy A., Gemicioğlu B., Fahrner H.B., Jung A., Deniz G., Akdis C.A., Akdis M. Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood. J. Allergy Clin. Immunol. 2013, 131:875-885.
120. Kulis M., Saba K., Kim E.H., Bird J.A., Kamilaris N., Vickery B.P., Staats H., Burks A.W. Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy. J. Allergy Clin. Immunol. 2012, 129:1159-1162.
121. Kunisawa J., Fukuyama S., Kiyono H. Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Curr. Mol. Med. 2005, 5:557-572.
122. Kunkel E.J., Butcher E.C. Chemokines and the tissue-specific migration of lymphocytes. Immunity 2002, 16:1-4.
123. Kunkel E.J., Kim C.H., Lazarus N.H., Vierra M.A., Soler D., Bowman E.P., Butcher E.C. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J. Clin. Invest. 2003, 111:1001-1010.
124. Kuper C.F., Koornstra P.J., Hameleers D.M.H., Biewenga J., Spit B.J., Duijvestijn A.M., van Breda Vriesman P.J.C., Sminia T. The role of nasopharyngeal lymphoid tissue. Immunol. Today 1992, 13:219-224.
125. Kusakari C., Takasaka T. Reconstitution of immunological imbalance in SCID mice given tonsillar mononuclear cells from patients with IgA nephropathy. Acta Otolaryngol. (Suppl.) 1993, 508:19-22.
126. Kusakari C., Nose M., Takasaka T., Yuasa R., Kato M., Miyazono K., Fujita T., Kyogoku M. Immunopathological features of palatine tonsil characteristic of IgA nephropathy: IgA1 localization in follicular dendritic cells. Clin. Exp. Immunol. 1994, 95:42-48.
127. Laichalk L.L., Hochberg D., Babcock G.J., Freeman R.B., Thorley-Lawson D.A. The dispersal of mucosal memory B cells: evidence from persistent EBV infection. Immunity 2002, 16:745-754.
128. Lee J.H., Kong S.K., Wu Z.S., Wu Q., Choe J., Cho H.Y., Ha S.Y., Kee S.H., Kim Y.S. Class II beta-tubulin is a novel marker for human tonsillar M cells and follicular dendritic cells. J. Oral Pathol. Med. 2010, 39:533-539.
129. Lee Y. Appendectomy, tonsillectomy, and neoplasia. J. Surg. Oncol. 1975, 7:237-241.
130. Lenander-Lumikari M., Tenovuo J., Puhakka H.J., Malvaranta T., Ruuskanen O., Meurman O., Meurman P., Vilja P. Salivary antimicrobial proteins and mutans streptococci in tonsillectomized children. Pediatr. Dent. 1992, 14:86-91.
131. Lim H.W., Hillsamer P., Banham A.H., Kim C.H. Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. J. Immunol. 2005, 175:4180-4183.
132. Lin, M., Du, L., Brandtzaeg, P., Pan-Hammarström, Q., 2014. IgA subclass switch recombination in human mucosal and systemic immune compartments. Mucosal Immunol. 7, 511-520.
133. Linterman M.A., Vinuesa C.G. T follicular helper cells during immunity and tolerance. Prog. Mol. Biol. Transl. Sci. 2010, 92:207-248.
134. Liu Y.-J., Arpin C. Germinal center development. Immunol. Rev. 1997, 156:111-126.
135. Liu Y.-J., Arpin C., deBouteiller O., Guret C., Banchereau J., Martinez-Valdez H., Lebecque S. Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center-development. Semin. Immunol. 1996, 8:169-177.
136. Liu Y.-J., Barthélémy C., de Bouteiller O., Arpin C., Durand I., Bachereau J. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 1995, 2:239-248.
137. Liu Y.-J., deBouteiller O., Arpin C., Durand I., Banchereau J. Five human mature B cell subsets. Adv. Exp. Med. Biol. 1994, 355:289-296.
138. Lu D., Hickey A.J. Pulmonary vaccine delivery. Expert Rev. Vaccines 2007, 6:213-226.
139. Ma C.S., Deenick E.K., Batten M., Tangye S.G. The origins, function, and regulation of T follicular helper cells. J. Exp. Med. 2012, 209:1241-1253.
140. MacLennan I.C.M. Germinal centers. Annu. Rev. Immunol. 1994, 12:117-139.
141. McClory S., Hughes T., Freud A.G., Briercheck E.L., Martin C., Trimboli A.J., Yu J., Zhang X., Leone G., Nuovo G., Caligiuri M.A. Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J. Clin. Invest. 2012, 122:1403-1415.
142. Meng H., Ohtake H., Ishida A., Ohta N., Kakehata S., Yamakawa M. IgA production and tonsillar focal infection in IgA nephropathy. J. Clin. Exp. Hematop. 2012, 52:161-170.
143. Miura M., Tomino Y., Suga T., Endoh M., Nomoto Y., Sakai H. Increase in proteinuria and/or microhematuria following upper respiratory tract infections in patients with IgA nephropathy. Tokai J. Exp. Clin. Med. 1984, 9:139-145.
144. Montaldo E., Vitale C., Cottalasso F., Conte R., Glatzer T., Ambrosini P., Moretta L., Mingari M.C. Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor. Blood 2012, 119:3987-3996.
145. Moser B., Schaerli P., Loetscher P. CXCR5+ T cells: follicular homing takes center stage in T-helper-cell responses. Trends Immunol. 2002, 23:250-254.
146. Mosmann T.R., Gravel Y., Williamson A.R., Baumal R. Modification and fate of J chain in myeloma cells in the presence and absence of polymeric immunoglobulin secretion. Eur. J. Immunol. 1978, 8:94-101.
147. Mueller N., Swanson G.M., Hsieh C.C., Cole P. Tonsillectomy and Hodgkin's disease: results from companion population-based studies. J. Natl. Cancer Inst. 1987, 78:1-5.
148. Mutsch M., Zhou W., Rhodes P., Bopp M., Chen R.T., Linder T., Spyr C., Steffen R. Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N. Engl. J. Med. 2004, 350:896-903.
149. Nadal D., Albini B., Chen C., Schläpfer E., Bernstein J.M., Ogra P.L. Distribution and engraftment patterns of human tonsillar mononuclear cells and immunoglobulin-secreting cells in mice with severe combined immunodeficiency: role of the Epstein-Barr virus. Int. Arch. Allergy Appl. Immunol. 1991, 95:341-351.
150. Nadal D., Soh N., Schlapfer E., Bernstein J.M., Ogra P.L. Distribution characteristics of immunoglobulin secreting cells in adenoids in relationship to age and disease. Int. J. Pediatr. Otorhinolaryngol. 1992, 24:121-130.
151. Nagy J., Brandtzaeg P. Tonsillar distribution of IgA and IgG immunocytes and production of IgA subclasses and J chain in tonsillitis vary with the presence or absence of IgA nephropathy. Scand. J. Immunol. 1988, 27:393-399.
152. Nishikawa Y., Sato H., Oka T., Yoshino T., Takahashi K. Immunohistochemical discrimination of plasmacytoid dendritic cells from myeloid dendritic cells in human pathological tissues. J. Clin. Exp. Hematop. 2009, 49:23-31.
153. Noda Y., Ura M. Pustulosis palmaris et plantaris due to tonsillar focal infections. From the analysis of long-term observed cases. Acta Otolaryngol. 1983, 401:22-30.
154. Ofuji S., Matsubara T., Watanabe S. On pustulosis palmaris et plantaris. Acta Dermatol. 1958, 53:385-389.
155. Ogier A., Franco M.A., Charpilienne A., Cohen J., Pothier P., Kohli E. Distribution and phenotype of murine rotavirus-specific B cells induced by intranasal immunization with 2/6 virus-like particles. Eur. J. Immunol. 2005, 35:2122-2130.
156. Ogra P.L. Effect of tonsillectomy and adenoidectomy on nasopharyngeal antibody response to poliovirus. N. Engl. J. Med. 1971, 284:59-64.
157. Östergaard P.A. IgA levels and carrier rate of pathogenic bacteria in 27 children previously tonsillectomized. Acta Pathol. Microbiol. Scand. C 1977, 85:178-186.
158. Özbilgin M.K., Polat S., Mete U.Ö., Tap Ö., Kaya M. Antigen-presenting cells in the hypertrophic pharyngeal tonsils: a histochemical, immunuhistochemical and ultrastructural study. J. Invest. Allergol. Clin. Immunol. 2004, 14:320-328.
159. Pabst R., Tschernig T. Bronchus-associated lymphoid tissue: an entry site for antigens for successful mucosal vaccinations?. Am. J. Respir. Cell Mol. Biol. 2010, 43:137-141.
160. Palomares O., Rückert B., Jartti T., Kücüksezer U.C., Puhakka T., Gomez E., Fahrner H.B., Speiser A., Jung A., Kwok W.W., Kalogjera L., Akdis M., Akdis C.A. Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance. J. Allergy Clin. Immunol. 2012, 129:510-520. 520.e1-9.
161. Paradise J.L., Bluestone C.D. Toward rational indications for tonsil and adenoid surgery. Hosp. Pract. 1976, 11:79-87.
162. Perry M.E. The specialized structure of crypt epithelium in the human palatine tonsil and its functional significance. J. Anat. 1994, 185:111-127.
163. Pido-Lopez J., Kwok W.W., Mitchell T.J., Heyderman R.S., Williams N.A. Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathog. 2011, 7:e1002396.
164. Plante M., Jones T., Allard F., Torossian K., Gauthier J., St-Felix N., White G.L., Lowell G.H., Burt D.S. Nasal immunization with subunit proteosome influenza vaccines induces serum HAI, mucosal IgA and protection against influenza challenge. Vaccine 2001, 20:218-225.
165. Platt A.M., Gibson V.B., Patakas A., Benson R.A., Nadler S.G., Brewer J.M., McInnes I.B., Garside P. Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells. J. Immunol. 2010, 185:1558-1567.
166. Preud'homme J.L., Petit I., Barra A., Morel F., Lecron J.C., Lelièvre E. Structural and functional properties of membrane and secreted IgD. Mol. Immunol. 2000, 37:871-887.
167. Quiding-Järbrink M., Granström G., Nordström I., Holmgren J., Czerkinsky C. Induction of compartmentalized B-cell responses in human tonsils. Infect. Immun. 1995, 63:853-857.
168. Quiding-Järbrink M., Nordström I., Granström G., Kilander A., Jertborn M., Butcher E.C., Lazarovits A.I., Holmgren J., Czerkinsky C. Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses. J. Clin. Invest. 1997, 99:1281-1286.
169. Ramos S.D., Mukerji S., Pine H.S. Tonsillectomy and adenoidectomy. Pediatr. Clin. North Am. 2013, 60:793-807.
170. Rasheed A.U., Rahn H.P., Sallusto F., Lipp M., Muller G. Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression. Eur. J. Immunol. 2006, 36:1892-1903.
171. Renz H., von Mutius E., Brandtzaeg P., Cookson W.O., Autenrieth I.B., Haller D. Gene-environment interactions in chronic inflammatory disease. Nat. Immunol. 2011, 12:273-277.
172. Rodríguez-Bayona B., Ramos-Amaya A., Bernal J., Campos-Caro A., Brieva J.A. Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells. J. Immunol. 2012, 188:1578-1581.
173. Rudin A., Johansson E.L., Bergquist C., Holmgren J. Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans. Infect. Immun. 1998, 66:3390-3396.
174. Russell M.W., Moldoveanu Z., White P.L., Sibert G.J., Mestecky J., Michalek S.M. Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the Cholera toxin B subunit. Infect. Immun. 1996, 64:1272-1283.
175. Sabouri S., Kobayashi M., Begum N.A., Xu J., Hirota K., Honjo T. C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:2253-2258.
176. Sanai A., Kudoh F. Effects of tonsillectomy in children with IgA nephropathy, purpura nephritis, or other chronic glomerulonephritides. Acta Otolaryngol. 1996, 523:172-174. Suppl.
177. Schaerli P., Willimann K., Lang A.B., Lipp M., Loetscher P., Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 2000, 192:1553-1562.
178. Shikina T., Hiroi T., Iwatani K., Jang M.H., Fukuyama S., Tamura M., Kubo T., Ishikawa H., Kiyono H. IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J. Immunol. 2004, 172:6259-6264.
179. Sigurdardottir S.L., Thorleifsdottir R.H., Valdimarsson H., Johnston A. The role of the palatine tonsils in the pathogenesis and treatment of psoriasis. Br. J. Dermatol. 2013, 168:237-242.
180. Sisirak V., Vey N., Vanbervliet B., Duhen T., Puisieux I., Homey B., Bowman E.P., Trinchieri G., Dubois B., Kaiserlian D., Lira S.A., Puisieux A., Blay J.Y., Caux C., Bendriss-Vermare N. CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues. Blood 2011, 118:5130-5140.
181. Slütter B., Bal S., Keijzer C., Mallants R., Hagenaars N., Que I., Kaijzel E., van Eden W., Augustijns P., Löwik C., Bouwstra J., Broere F., Jiskoot W. Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen. Vaccine 2010, 28:6282-6291.
182. Sminia T., van der Brugge-Gamelkoorn G.J., Jeurissen S.H. Structure and function of bronchus-associated lymphoid tissue (BALT). Crit. Rev. Immunol. 1989, 9:119-150.
183. Spencer J., Perry M.E., Dunn-Walters D.K. Human marginal-zone B cells. Immunol. Today 1998, 19:421-426.
184. Stoltenberg L., Vege Å., Saugstad O.D., Rognum T.O. Changes in the concentration and distribution of immunoglobulin-producing cells in SIDS palatine tonsils. Pediatr. Allergy Immunol. 1995, 6:48-55.
185. Surjan L., Brandtzaeg P., Berdal P. Immunoglobulin systems of human tonsils. II. Patients with chronic tonsillitis or tonsillar hyperplasia: quantification of Ig-producing cells, tonsillar morphometry and serum Ig concentrations. Clin. Exp. Immunol. 1978, 31:382-390.
186. Takahara M. Clinical outcome of tonsillectomy for palmoplantar pustulosis and etiological relationship between palmoplantar pustulosis and tonsils. Adv. Otorhinolaryngol. 2011, 72:86-88.
187. Tanaka N., Ichino Y., Ikawa T., Ishikawa T. Immunological study of Pustulosis palmaris et plantaris - Blastoid transformation of tonsil and perhipheral blood lymphocytes by stimulation with human skin extract. Acta Otolaryngol. (Suppl.) 1983, 401:68-74.
188. Thomsen K., Österbye P. Pustulosis palmaris et plantaris. Br. J. Dermatol. 1973, 89:293-296.
189. Thrane P., Rognum T.O., Brandtzaeg P. Increased immune response in upper respiratory and digestive tracts in SIDS. Lancet 1990, 335:229-230.
190. Todorović M.M., Zvrko E.Z. Immunoregulatory cytokines and chronic tonsillitis. Bosn. J. Basic Med. Sci. 2013, 13:230-236.
191. Tokuda M., Shimizu J., Sugiyama N., Kiryu T., Matsuoka K., Sasaki O., Fukuda K., Hatase O., Monden H. Direct evidence of the production of IgA by tonsillar lymphocytes and the binding of IgA to the glomerular mesangium of IgA nephropathy patients. Acta Otolaryngol. 1996, 523:182-184. Suppl.
192. Treanor J., Nolan C., O'Brien D., Burt D., Lowell G., Linden J., Fries L. Intranasal administration of a proteosome-influenza vaccine is well-tolerated and induces serum and nasal secretion influenza antibodies in healthy human subjects. Vaccine 2006, 24:254-262.
193. Uehara Y., Nakama H., Agematsu K., Uchida M., Kawakami Y., Abdul Fattah A.S., Maruchi N. Bacterial interference among nasal inhabitants: eradication of Staphylococcus aureus from nasal cavities by artificial implantation of Corynebacterium sp. J. Hosp. Infect. 2000, 44:127-133.
194. Vajdy M., Singh M. Intranasal delivery of vaccines against HIV. Expert Opin. Drug. Deliv. 2006, 3:247-259.
195. Van der Brugge-Gamelkoorn G.J., Claassen E., Sminia T. Anti-TPN-forming cells in bronchus-associated lymphoid tissue (BALT) and paratracheal lymph node (PTLN) of the rat after intratracheal priming and boosting with TNP-KLH. Immunology 1986, 57:405-409.
196. van Laar J.M., Melchers M., Teng Y.K., van der Zouwen B., Mohammadi R., Fischer R., Margolis L., Fitzgerald W., Grivel J.C., Breedveld F.C., Lipsky P.E., Grammer A.C. Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells. Am. J. Pathol. 2007, 171:917-927.
197. Verbrugghe P., Kujala P., Waelput W., Peters P.J., Cuvelier C.A. Clusterin in human gut-associated lymphoid tissue, tonsils, and adenoids: localization to M cells and follicular dendritic cells. Histochem. Cell Biol. 2008, 129:311-320.
198. Vestergaard H., Westergaard T., Wohlfahrt J., Hjalgrim H., Melbye M. Tonsillitis, tonsillectomy and Hodgkin's lymphoma. Int. J. Cancer 2010, 127:633-637.
199. Vianna N.J., Lawrence C.E., Davies J.N., Arbuckle J., Harris S., Marani W., Wilkinson J. Tonsillectomy and childhood Hodgkin's disease. Lancet II 1980, 338-340.
200. Wang X., Cho B., Suzuki K., Xu Y., Green J.A., An J., Cyster J.G. Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers. J. Exp. Med. 2011, 208:2497-2510.
201. Wollenberg I., Agua-Doce A., Hernández A., Almeida C., Oliveira V.G., Faro J., Graca L. Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells. J. Immunol. 2011, 187:4553-4560.
202. Wu H.Y., Russell M.W. Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system. Immunol. Res. 1997, 16:187-201.
203. Wu H.Y., Nguyen H.H., Russell M.W. Nasal lymphoid tissue (NALT) as a mucosal immune inductive site. Scand. J. Immunol. 1997, 46:506-513.
204. Xu W., He B., Chiu A., Chadburn A., Shan M., Buldys M., Ding A., Knowles D.M., Santini P.A., Cerutti A. Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nat. Immunol. 2007, 8:294-303.
205. Xu W., Santini P.A., Matthews A.J., Chiu A., Plebani A., He B., Chen K., Cerutti A. Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF. J. Immunol. 2008, 181:276-287.
206. Xu W., Joo H., Clayton S., Dullaers M., Herve M.C., Blankenship D., De La Morena M.T., Balderas R., Picard C., Casanova J.L., Pascual V., Oh S., Banchereau J. Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J. Exp. Med. 2012, 209:1813-1823. S1-2.
207. Yamanaka N., Sambe S., Kataura A. Conceptual understanding of pustulosis palmaris et plantaris as an immune complex disease due to focal tonsillar infections. Acta Otolaryngol. 1983, 401:31-35. Suppl.
208. Yamanaka N., Shido F., Kataura A. Tonsillectomy-induced changes in anti-keratin antibodies in patients with pustulosis palmariset plantaris: a clinical correlation. Arch. Otorhinolaryngol 1989, 246:109-112.
209. Yanagita M., Hiroi T., Kitagaki N., Hamada S., Ito H.O., Shimauchi H., Murakami S., Okada H., Kiyono H. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. J. Immunol. 1999, 162:3559-3565.
210. Yoon S.O., Zhang X., Lee I.Y., Spencer N., Vo P., Choi Y.S. CD9 is a novel marker for plasma cell precursors in human germinal centers. Biochem. Biophys. Res. Commun. 2013, 431:41-46.
211. Yu D., Vinuesa C.G. The elusive identity of T follicular helper cells. Trends Immunol. 2010, 31:377-383.
212. Zhang Q., Leong S.C., McNamara P.S., Mubarak A., Malley R., Finn A. Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: relationships with pneumococcal colonization. PLoS Pathog. 2011, 7:e1002175.
213. Zhang Y., Meyer-Hermann M., George L.A., Figge M.T., Khan M., Goodall M., Young S.P., Reynolds A., Falciani F., Waisman A., Notley C.A., Ehrenstein M.R., Kosco-Vilbois M., Toellner K.M. Germinal center B cells govern their own fate via antibody feedback. J. Exp. Med. 2013, 210:457-464.
214. Zheng N.-Y., Wilson K., Wang X., Boston A., Kolar G., Jackson S.M., Liu Y.J., Pascual V., Capra J.D., Wilson P.C. Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C™ class-switched B cells. J. Clin. Invest. 2004, 113:1188-1201.