Gene Interaction Network Regulates Plasma Cell Differentiation

Scandinavian Journal of Immunology

Volumn 73, Issue 6, 2011, Pages 512-519

  Alinikula, J ^a   Lassila, O ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

B LYMPHOCYTE; CELL DIFFERENTIATION; CELL TYPE; GERMINAL CENTER; HUMORAL IMMUNITY; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; GENE REGULATORY NETWORKS; GERMINAL CENTER; HUMANS; IMMUNITY, HUMORAL; PLASMA CELLS; TRANSCRIPTION FACTORS;

EID: 79955429556     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2011.02556.x     Document Type: Review

References (89)

1. Oracki SA, Walker JA, Hibbs ML, Corcoran LM, Tarlinton DM. Plasma cell development and survival. Immunol Rev 2010;237:140-59.
2. Fairfax KA, Kallies A, Nutt SL, Tarlinton DM. Plasma cell development: from B-cell subsets to long-term survival niches. Semin Immunol 2008;20:49-58.
3. Paus D, Phan TG, Chan TD, Gardam S, Basten A, Brink R. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J Exp Med 2006;203:1081-91.
4. MacLennan I, Vinuesa C. Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. Immunity 2002;17:235-8.
5. Radbruch A, Muehlinghaus G, Luger EO et al. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol 2006;6:741-50.
6. Alinikula J, Kohonen P, Nera KP, Lassila O. Concerted action of Helios and Ikaros controls the expression of the inositol 5-phosphatase SHIP. Eur J Immunol 2010;40:2599-607.
7. Nera KP, Alinikula J, Terho P et al. Ikaros has a crucial role in regulation of B cell receptor signaling. Eur J Immunol 2006;36:516-25.
8. Nera KP, Kohonen P, Narvi E et al. Loss of Pax5 promotes plasma cell differentiation. Immunity 2006;24:283-93.
9. Nera KP, Lassila O. Pax5 - a critical inhibitor of plasma cell fate. Scand J Immunol 2006;64:190-9.
10. Merkenschlager M. Ikaros in immune receptor signaling, lymphocyte differentiation, and function. FEBS Lett 2010;584:4910-4.
11. Narvi E, Nera KP, Terho P, Mustonen L, Granberg J, Lassila O. Aiolos controls gene conversion and cell death in DT40 B cells. Scand J Immunol 2007;65:503-13.
12. Alinikula J, Lassila O, Nera KP. DT40 mutants: a model to study transcriptional regulation of B cell development and function. Subcell Biochem 2006;40:189-205.
13. Cariappa A, Tang M, Parng C et al. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity 2001;14:603-15.
14. Cortes M, Georgopoulos K. Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity. J Exp Med 2004;199:209-19.
15. Shaffer AL, Lin KI, Kuo TC et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002;17:51-62.
16. Mittrucker HW, Matsuyama T, Grossman A et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 1997;275:540-3.
17. Reimold AM, Iwakoshi NN, Manis J et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature 2001;412:300-7.
18. Shapiro-Shelef M, Lin KI, McHeyzer-Williams LJ, Liao J, McHeyzer-Williams MG, Calame K. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 2003;19:607-20.
19. Blink EJ, Light A, Kallies A, Nutt SL, Hodgkin PD, Tarlinton DM. Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J Exp Med 2005;201:545-54.
20. Kallies A, Hasbold J, Tarlinton DM et al. Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med 2004;200:967-77.
21. Savitsky D, Calame K. B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion. J Exp Med 2006;203:2305-14.
22. Turner CA Jr, Mack DH, Davis MM. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 1994;77:297-306.
23. Martins G, Calame K. Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol 2008;26:133-69.
24. Lin Y, Wong K, Calame K. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science 1997;276:596-9.
25. Lin KI, Angelin-Duclos C, Kuo TC, Calame K. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol Cell Biol 2002;22:4771-80.
26. Shapiro-Shelef M, Lin KI, Savitsky D, Liao J, Calame K. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med 2005;202:1471-6.
27. Kallies A, Hasbold J, Fairfax K et al. Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity 2007;26:555-66.
28. Delogu A, Schebesta A, Sun Q, Aschenbrenner K, Perlot T, Busslinger M. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity 2006;24:269-81.
29. Lu R, Medina KL, Lancki DW, Singh H. IRF-4, 8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev 2003;17:1703-8.
30. Cattoretti G, Shaknovich R, Smith PM, Jack HM, Murty VV, Alobeid B. Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance. J Immunol 2006;177:6930-9.
31. Falini B, Fizzotti M, Pucciarini A et al. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 2000;95:2084-92.
32. Klein U, Casola S, Cattoretti G et al. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol 2006;7:773-82.
33. Sciammas R, Shaffer AL, Schatz JH, Zhao H, Staudt LM, Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 2006;25:225-36.
34. Shaffer AL, Shapiro-Shelef M, Iwakoshi NN et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 2004;21:81-93.
35. Reimold AM, Ponath PD, Li YS et al. Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1. J Exp Med 1996;183:393-401.
36. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001;107:881-91.
37. Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K, Glimcher LH. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 2003;4:321-9.
38. Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003;23:7448-59.
39. Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol 2008;8:22-33.
40. Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997;276:589-92.
41. Ye BH, Cattoretti G, Shen Q et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 1997;16:161-70.
42. Cattoretti G, Pasqualucci L, Ballon G et al. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell 2005;7:445-55.
43. Cattoretti G, Chang CC, Cechova K et al. BCL-6 protein is expressed in germinal-center B cells. Blood 1995;86:45-53.
44. Allman D, Jain A, Dent A et al. BCL-6 expression during B-cell activation. Blood 1996;87:5257-68.
45. Duy C, Yu JJ, Nahar R et al. BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med 2010;207:1209-21.
46. Kuo TC, Shaffer AL, Haddad J Jr, Choi YS, Staudt LM, Calame K. Repression of BCL-6 is required for the formation of human memory B cells in vitro. J Exp Med 2007;204:819-30.
47. Linterman MA, Beaton L, Yu D et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 2010;207:353-63.
48. Arguni E, Arima M, Tsuruoka N, Sakamoto A, Hatano M, Tokuhisa T. JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells. Int Immunol 2006;18:1079-89.
49. Zotos D, Coquet JM, Zhang Y et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 2010;207:365-78.
50. Chtanova T, Tangye SG, Newton R et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004;173:68-78.
51. Vinuesa CG, Linterman MA, Goodnow CC, Randall KL. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol Rev 2010;237:72-89.
52. Scheeren FA, Naspetti M, Diehl S et al. STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Nat Immunol 2005;6:303-13.
53. Ozaki K, Spolski R, Ettinger R et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 2004;173:5361-71.
54. Shaffer AL, Yu X, He Y, Boldrick J, Chan EP, Staudt LM. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 2000;13:199-212.
55. Ranuncolo SM, Polo JM, Melnick A. BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. Blood Cells Mol Dis 2008;41:95-9.
56. Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000;102:553-63.
57. Yoshikawa K, Okazaki IM, Eto T et al. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 2002;296:2033-6.
58. Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T. The AID enzyme induces class switch recombination in fibroblasts. Nature 2002;416:340-5.
59. Gonda H, Sugai M, Nambu Y et al. The balance between Pax5 and Id2 activities is the key to AID gene expression. J Exp Med 2003;198:1427-37.
60. Toyama H, Okada S, Hatano M et al. Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 2002;17:329-39.
61. Tunyaplin C, Shaffer AL, Angelin-Duclos CD, Yu X, Staudt LM, Calame KL. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J Immunol 2004;173:1158-65.
62. Reljic R, Wagner SD, Peakman LJ, Fearon DT. Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6. J Exp Med 2000;192:1841-8.
63. Ochiai K, Muto A, Tanaka H, Takahashi S, Igarashi K. Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. Int Immunol 2008;20:453-60.
64. Lin L, Gerth AJ, Peng SL. Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor. J Exp Med 2004;200:115-22.
65. Ochiai K, Katoh Y, Ikura T et al. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem 2006;281:38226-34.
66. Cobaleda C, Schebesta A, Delogu A, Busslinger M. Pax5: the guardian of B cell identity and function. Nat Immunol 2007;8:463-70.
67. Mora-Lopez F, Reales E, Brieva JA, Campos-Caro A. Human BSAP and BLIMP1 conform an autoregulatory feedback loop. Blood 2007;110:3150-7.
68. Usui T, Wakatsuki Y, Matsunaga Y, Kaneko S, Koseki H, Kita T. Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype. J Immunol 1997;158:3197-204.
69. Morrison AM, Nutt SL, Thevenin C, Rolink A, Busslinger M. Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation. Semin Immunol 1998;10:133-42.
70. Rinkenberger JL, Wallin JJ, Johnson KW, Koshland ME. An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene. Immunity 1996;5:377-86.
71. Wallin JJ, Gackstetter ER, Koshland ME. Dependence of BSAP repressor and activator functions on BSAP concentration. Science 1998;279:1961-4.
72. Wallin JJ, Rinkenberger JL, Rao S, Gackstetter ER, Koshland ME, Zwollo P. B cell-specific activator protein prevents two activator factors from binding to the immunoglobulin J chain promoter until the antigen-driven stages of B cell development. J Biol Chem 1999;274:15959-65.
73. Singh M, Birshtein BK. NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation. Mol Cell Biol 1993;13:3611-22.
74. Niu H, Ye BH, Dalla-Favera R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev 1998;12:1953-61.
75. Cimmino L, Martins GA, Liao J et al. Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression. J Immunol 2008;181:2338-47.
76. Saito M, Gao J, Basso K et al. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell 2007;12:280-92.
77. Igarashi K, Ochiai K, Muto A. Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation. J Biochem 2007;141:783-9.
78. Muto A, Tashiro S, Nakajima O et al. The transcriptional programme of antibody class switching involves the repressor Bach2. Nature 2004;429:566-71.
79. Muto A, Ochiai K, Kimura Y et al. Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch. EMBO J 2010;29:4048-61.
80. Muto A, Hoshino H, Madisen L et al. Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J 1998;17:5734-43.
81. Nurieva RI, Chung Y, Martinez GJ et al. Bcl6 mediates the development of T follicular helper cells. Science 2009;325:1001-5.
82. Yu D, Rao S, Tsai LM et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009;31:457-68.
83. Johnston RJ, Poholek AC, DiToro D et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009;325:1006-10.
84. Nurieva RI, Chung Y, Hwang D et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008;29:138-49.
85. Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008;29:127-37.
86. Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res 2005;65:5054-62.
87. Crotty S, Johnston RJ, Schoenberger SP. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol 2010;11:114-20.
88. Pelletier N, McHeyzer-Williams LJ, Wong KA, Urich E, Fazilleau N, McHeyzer-Williams MG. Plasma cells negatively regulate the follicular helper T cell program. Nat Immunol 2010;11:1110-8.
89. Victora GD, Schwickert TA, Fooksman DR et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 2010;143:592-605.