The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cμ-Cδ switch, and λ light chain expression

Journal of Experimental Medicine

Volumn 187, Issue 8, 1998, Pages 1169-1178

  Arpin, Christophe ^a   De Bouteiller, Odette ^a   Razanajaona, Diane ^a   Fugier Vivier, Isabelle ^a   Brière, Francine ^a   Banchereau, Jacques ^a,b   Lebecque, Serge ^a   Liu, Yong Jun ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; COMPLEMENTARY DNA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN M; MESSENGER RNA;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGLOBULIN VARIABLE REGION; MEMORY CELL; MYELOMA CELL; NUCLEOTIDE SEQUENCE; PLASMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

B-LYMPHOCYTES; BASE SEQUENCE; CELL DIFFERENTIATION; GENES, IMMUNOGLOBULIN; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN D; IMMUNOGLOBULIN DELTA-CHAINS; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN MU-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; MOLECULAR SEQUENCE DATA; MULTIPLE MYELOMA; MUTATION; PLASMA CELLS; RECOMBINATION, GENETIC;

EID: 0032550340     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.8.1169     Document Type: Article

References (52)

1. Rowe, D.S., K. Hug, L. Forni, and B. Pernis. 1973. Immunoglobulin D as a lymphocyte receptor. J. Exp. Med. 138: 965-972.
2. Pernis, B., J.C. Brouet, and M. Seligmann. 1974. IgD and IgM on the membrane of lymphoid cells in macroglobulinemia. Evidence for identity of membrane IgD and IgM antibody activity in a case with anti-IgG receptors. Eur. J. Immunol. 4:776-778.
3. Salsano, F., S.S. Froland, J.B. Natvig, and T.E. Michaelsen. 1974. Same idiotype of B-lymphocyte membrane IgD and IgM. Formal evidence for monoclonality of chronic lymphocytic leukemia cells. Scand. J. Immunol. 3:841-846.
4. Fu, S.M., R.J. Winchester, and H.G. Kunkel. 1975. Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes. J. Immunol. 114:250-252.
5. Goding, J.W., and J.E. Layton. 1976. Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells. J. Exp. Med. 144:857.
6. Stern, C., and I. McConnell. 1976. Immunoglobulins M and D as antigen-binding receptors on the same cell, with shared specificity. Eur. J. Immunol. 6:225-227.
7. Vitetta, E.S., and J.W. Uhr. 1976. Cell surface immunoglobulin. XV. The presence of IgM and an IgD-like molecule on the same cell in murine lymphoid tissue. Eur. J. Immunol. 6: 140-143.
8. Parkhouse, R.M., and M.D. Cooper. 1977. A model for the differentiation of B lymphocytes with implications for the biological role of IgD. Immunol. Rev. 37:105-126.
9. Blattner, F.R., and P.W. Tucker. 1984. The molecular biology of immunoglobulin D. Nature. 307:417-422.
10. Ligthart, G.J., H.R. Schuit, and W. Hijmans. 1985. Subpopulations of mononuclear cells in aging: expansion of the null cell compartment and decrease in the number of T and B cells in human blood. Immunology. 55:15-21.
11. Fine, J.M., C. Rivat, P. Lambin, and C. Ropartz. 1974. Monoclonal IgD. A comparative study of 60 sera with IgD "M" component. Biomedicine. 21:119-125.
12. Fibbe, W.E., and J. Jansen. 1984. Prognostic factors in IgD myeloma: a study of 21 cases. Scand. J. Haematol. 33:471-475.
13. Gilliam, A.C., A. Shen, J.E. Richards, F.R. Blattner, J.F. Mushinski, and P.W. Tucker. 1984. Illegitimate recombination generates a class switch from C mu to C delta in an IgD-secreting plasmacytoma. Proc. Natl. Acad. Sci. USA. 81:4164-4168.
14. Yasui, H., Y. Akahori, M. Hirano, K. Yamada, and Y. Kurosawa. 1989. Class switch from μ to δ is mediated by homologous recombination between σμ and Âδ sequences in human immunoglobulin gene loci. Eur. J. Immunol. 19:1399-1403.
15. White, M.B., C.J. Word, C.G. Humphries, F.R. Blattner, and P.W. Tucker. 1990. Immunoglobulin D switching can occur homologous recombination in human B cells. Mol. Cell. Biol. 10:3690-3699.
16. Kluin, P.M., H. Kayano, V.J. Zani, H.C. Kluin-Nelemans, P.W. Tucker, E. Satterwhite, and M.J.S. Dyer. 1995. IgD class switching: identification of a novel recombination site in neoplastic and normal B cells. Eur. J. Immunol. 25:3504-3508.
17. Bergsagel, D.E. 1979. Treatment of plasma cell myeloma. Annu. Rev. Med. 30:431-443.
18. Greipp, P.R. 1992. Advances in the diagnosis and management of myeloma. Semin. Hematol. 29:24-45.
19. Epstein, J., H.Q. Xiao, and X.Y. He. 1990. Markers of multiple hematopoietic-cell lineages in multiple myeloma. New Engl. J. Med. 322:664-668.
20. Kubagawa, H., L.B. Vogler, J.D. Capra, M.E. Conrad, A.R. Lawton, and M.D. Cooper. 1979. Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation. J. Exp. Med. 150:792-807.
21. Warburton, P., D.E. Joshua, J. Gibson, and R.D. Brown. 1989. CD10-(CALLA)-positive lymphocytes in myeloma: evidence that they are a malignant precursor population and are of germinal centre origin. Leuk. Lymphoma. 1:11-18.
22. Jensen, G.S., M.J. Mant, A.J. Belch, J.R. Berenson, B.A. Ruether, and L.M. Pilarski. 1991. Selective expression of CD45 isoforms defines CALLA+ monoclonal B-lineage cells in peripheral blood from myeloma patients as late stage B cells. Blood. 78:711-719.
23. Sahota, S.S., R. Leo, T.J. Hamblin, and F.K. Stevenson. 1996. Ig VH gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance. Blood. 87:746-755.
24. MacLennan, I.C.M., and E.Y.T. Chan. 1991. The origin of bone marrow plasma cells. In Epidemiology and Biology of Multiple Myeloma. G.I. Obrams and M. Potter, editors. Springer-Verlag, Berlin. 129-135.
25. Bakkus, M.H., C. Heirman, I. Van Riet, B. Van Camp, and K. Thielemans. 1992. Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood. 80:2326-2335.
26. Baker, B.W., M. Deane, M.H. Gilleece, D. Johnston, J.H. Scarffe, and J.D. Norton. 1994. Distinctive features of immunoglobulin heavy chain variable region gene rearrangement in multiple myeloma. Leuk. Lymphoma. 14:291-301.
27. Wagner, S.D., V. Martinelli, and L. Luzzatto. 1994. Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma. Blood. 83:3647-3653.
28. Kosmas, C., K. Stamatopoulos, and D. Loukopoulos. 1997. Antigen selection of multiple myeloma clonogenic B cells as evidenced by V(H) and V(L) gene mutations. Blood. 90: 1334-1335.
29. Biggs, D.D., P. Kraj, J. Goldman, L. Jefferies, C. Carchidi, K. Anderson, and L.E. Silberstein. 1995. Immunoglobulin gene sequence analysis to further assess B-cell origin of multiple myeloma. Clin. Diagn. Lab. Immunol. 2:44-52.
30. Kosmas, C., N.A. Viniou, K. Stamatopoulos, N.S. Courtenay-Luck, T. Papadaki, P. Kollia, G. Paterakis, D. Anagnostou, X. Yataganas, and D. Loukopoulos. 1996. Analysis of the kappa light chain variable region in multiple myeloma. Br. J. Haematol. 94:306-317.
31. Rettig, M.B., R.A. Vescio, J. Cao, C.H. Wu, J.C. Lee, E. Han, M. DerDanielian, R. Newman, C. Hong, A.K. Lichtenstein, and J.R. Berenson. 1996. VH gene usage in multiple myeloma: complete absence of the VH4.21 (VH4-34) gene. Blood. 87:2846-2852.
32. Kiyoi, H., K. Naito, R. Ohno, and T. Naoe. 1996. Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes. Leukemia (Baltimore). 10:1804-1812.
33. Sahota, S.S., R. Leo, T.J. Hamblin, and F.K. Stevenson. 1997. Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells. Blood. 89:219-226.
34. Flückiger, A.C., P. Garrone, I. Durand, J.P. Galizzi, and J. Banchereau. 1993. Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J. Exp. Med. 178:1473-1481.
35. Pascual, V., Y.J. Liu, A. Magalski, O. de Bouteiller, J. Banchereau, and J.D. Capra. 1994. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180: 329-339.
36. - transcripts. Immunity. 4:603-613.
37. Lebecque, S., O. de Bouteiller, C. Arpin, J. Banchereau, and Y.J. Liu. 1997. Germinal center founder cells display propensity for apoptosis before onset of somatic mutation. J. Exp. Med. 185:563-571.
38. Rousset, F., E. Garcia, T. Defrance, C. Péronne, N. Vezzio, D.H. Hsu, R. Kastelein, K.W. Moore, and J. Banchereau. 1992. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. USA. 89:1890-1893.
39. Malisan, F., F. Brière, J.-M. Bridon, N. Harindranath, F.C. Mills, E.E. Max, J. Banchereau, and H. Martinez-Valdez. 1996. Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes. J. Exp. Med. 183:937-947.
40. Ferrarini, M., G. Corte, G. Viale, M.L. Durante, and A. Bargellesi. 1976. Membrane Ig on human lymphocytes: rate of turnover of IgD and IgM on the surface of human tonsil cells. Eur. J. Immunol. 6:372-378.
41. Brandtzaeg, P., and T.S. Halstensen. 1992. Immunology and immunopathology of tonsils. Adv. Oto-Rhino-Laryngol. 47: 64-75.
42. Merville, P., J. Déchanet, A. Desmoulière, I. Durand, O. de Bouteiller, P. Garrone, J. Banchereau, and Y.J. Liu. 1996. Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts. J. Exp. Med. 183:227-236.
43. Klein, U., R. Küppers, and K. Rajewsky. 1994. Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age. J. Exp. Med. 180: 1383-1393.
44. Rowe, D.S., and J.L. Fahey. 1965. A new class of human immunoglobulins. I. A unique myeloma protein. J. Exp. Med. 121:171-184.
45. Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999-1008.
46. Tiegs, S.L., D.M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009-1020.
47. Han, S., B. Zheng, D.G. Schatz, E. Spanopoulou, and G. Kelsoe. 1996. Neoteny in lymphocytes: Rag-1 and Rag-2 expression in germinal center B cells. Science. 274:2094-2097.
48. Hikida, M., M. Mori, T. Takai, K.I. Tomochika, K. Hamatani, and H. Ohmori. 1996. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science. 2092-2094.
49. Han, S., S.R. Dillon, B. Zheng, M. Shimoda, M.S. Schlissel, and G. Kelsoe. 1997. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 278:301-305.
50. Papavasiliou, F., R. Casellas, H. Suh, X.F. Qin, E. Besmer, R. Pelanda, D. Nemazee, K. Rajewsky, and M.C. Nussenzweig. 1997. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science. 5336:298-301.
51. Paramithiotis, E., and M.D. Cooper. 1997. Memory B lymphocytes migrate to bone marrow in humans. Proc. Natl. Acad. Sci. USA. 94:208-212.
52. Moskophidis, D., M. Moskophidis, and J. Löhler. 1997. Virus-specific IgD in acute viral infection of mice. J. Immunol. 158:1254-1261.