Characterisation of regulatory t cells in nasal associated lymphoid tissue in children: Relationships with pneumococcal colonization

PLoS Pathogens

Volumn 7, Issue 8, 2011, Pages

  Zhang, Qibo ^a   Leong, Samuel C ^b   McNamara, Paul S ^b   Mubarak, Ayman ^a   Malley, Richard ^c   Finn, Adam ^d  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ALDER HEY CHILDREN S HOSPITAL   (United Kingdom)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CD39 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; APYRASE; CD38 ANTIGEN; CTLA4 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

ADENOID; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CARRIER; BACTERIUM CULTURE; CD4+ T LYMPHOCYTE; CELL STIMULATION; CHILD; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; NASOPHARYNX; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; REGULATORY T LYMPHOCYTE; STREPTOCOCCUS PNEUMONIAE; T LYMPHOCYTE SUBPOPULATION; BIOSYNTHESIS; IMMUNOLOGY; MICROBIOLOGY; PNEUMOCOCCAL INFECTION;

STREPTOCOCCUS PNEUMONIAE;

ADENOIDS; ANTIGENS, CD; ANTIGENS, CD38; APYRASE; CD4-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; CTLA-4 ANTIGEN; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; NASOPHARYNX; PNEUMOCOCCAL INFECTIONS; T-LYMPHOCYTES, REGULATORY;

EID: 80052322279     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002175     Document Type: Article

References (43)

1. Sakaguchi S, Sakaguchi S, (2004) Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22: 531-562.
2. Belkaid Y, Belkaid Y, (2008) Role of Foxp3-positive regulatory T cells during infection. Eur J Immunol 38: 918-921.
3. Chen W, Jin W, Hardegen N, Lei KJ, Li L, et al. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198: 1875-1886.
4. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, et al. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 203: 1693-1700.
5. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203: 1701-1711.
6. Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, et al. (2009) CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol 183: 7602-7610.
7. Izcue A, Coombes JL, Powrie F, Izcue A, Coombes JL, et al. (2006) Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev 212: 256-271.
8. Zheng Y, Manzotti CN, Burke F, Dussably L, Qureshi O, et al. (2008) Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. J Immunol 181: 1683-1691.
9. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, et al. (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science 322: 271-275.
10. Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, et al. (2007) Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225-1232.
11. Rouse BT, Sarangi PP, Suvas S, Rouse BT, Sarangi PP, et al. (2006) Regulatory T cells in virus infections. Immunol Rev 212: 272-286.
12. Epple HJ, Loddenkemper C, Kunkel D, Troger H, Maul J, et al. (2006) Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 108: 3072-3078.
13. Kinter AL, Hennessey M, Bell A, Kern S, Lin Y, et al. (2004) CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 200: 331-343.
14. Bolacchi F, Sinistro A, Ciaprini C, Demin F, Capozzi M, et al. (2006) Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels. Clin & Exp Immunol 144: 188-196.
15. Guyot-Revol V, Innes JA, Hackforth S, Hinks T, Lalvani A, et al. (2006) Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis. Am J Respir Crit Care Med 173: 803-810.
16. Raghavan S, Holmgren J, Raghavan S, Holmgren J, (2005) CD4+CD25+ suppressor T cells regulate pathogen induced inflammation and disease. FEMS Immunol & Med Microbiol 44: 121-127.
17. Zhang Q, Bernatoniene J, Bagrade L, Pollard AJ, Mitchell TJ, et al. (2006) Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status. Eur J Immunol 36: 46-57.
18. Zhang Q, Bernatoniene J, Bagrade L, Clarke E, Paton JC, et al. (2007) Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children. J Infect Dis 195: 1194-1202.
19. Brandtzaeg P, (2003) Immunology of tonsils and adenoids: everything the ENT surgeon needs to know. Int J Pediatr Otorhinolaryngol 67 (Suppl 1): S69-S76.
20. Kiyono H, Fukuyama S, Kiyono H, Fukuyama S, (2004) NALT- versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol 4: 699-710.
21. McMichael AJ, Rowland-Jones S, (2001) Cellular immune responses to HIV. Nature 410: 980-987.
22. Cooper AM, Cooper AM, (2009) Cell-mediated immune responses in tuberculosis. Annu Rev Immunol 27: 393-422.
23. Malley R, Trzcinski K, Srivastava A, Thompson CM, Anderson PW, et al. (2005) CD4 T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc Natl Acad Sci USA 102: 4848-4853.
24. McCool TL, Weiser JN, (2004) Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization. Infect Immun 72: 5807-5813.
25. Kadioglu A, Coward W, Colston MJ, Hewitt CR, Andrew PW, (2004) CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect Immun 72: 2689-2697.
26. Malley R, Lipsitch M, Stack A, Saladino R, Fleisher G, et al. (2001) Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci. Infect Immun 69: 4870-4873.
27. Sung CK, Li H, Claverys JP, Morrison DA, Sung CK, et al. (2001) An rpsL cassette, janus, for gene replacement through negative selection in Streptococcus pneumoniae. Appl & Environ Microbiol 67: 5190-5196.
28. Zhang Q, Bagrade L, Clarke E, Paton JC, Nunez DA, et al. (2010) Bacterial lipoproteins differentially regulate human primary and memory CD4+ T and B cell responses to pneumococcal protein antigens through Toll-like receptor 2. J Infect Dis 201: 1753-1763.
29. Zhang Q, Bernatoniene J, Bagrade L, Paton JC, Mitchell TJ, et al. (2006) Regulation of mucosal antibody production to pneumococcal protein antigens by T-cell derived IFNg and IL-10 in children. Infect Immun 74: 4735-4743.
30. Sakaguchi S, Miyara M, Costantino CM, Hafler DA, Sakaguchi S, et al. (2010) FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 10: 490-500.
31. Valmori D, Merlo A, Souleimanian NE, Hesdorffer CS, Ayyoub M, et al. (2005) A peripheral circulating compartment of natural naive CD4 Tregs. J Clin Invest 115: 1953-1962.
32. Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, et al. (2009) Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30: 899-911.
33. Fritzsching B, Oberle N, Pauly E, Geffers R, Buer J, et al. (2006) Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death. Blood 108: 3371-3378.
34. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA, Baecher-Allan C, et al. (2001) CD4+CD25high regulatory cells in human peripheral blood. J Immunol 167: 1245-1253.
35. Andersson J, Boasso A, Nilsson J, Zhang R, Shire NJ, et al. (2005) The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. J Immunol 174: 3143-3147.
36. Shafiani S, Tucker-Heard G, Kariyone A, Takatsu K, Urdahl KB, et al. (2010) Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med 207: 1409-1420.
37. Nilsson J, Boasso A, Velilla PA, Zhang R, Vaccari M, et al. (2006) HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood 108: 3808-3817.
38. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL, et al. (2002) CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420: 502-507.
39. Maizels RM, Maizels RM, (2005) Infections and allergy- helminths, hygiene and host immune regulation. Curr Opin Immunol 17: 656-661.
40. Lu YJ, Gross J, Bogaert D, Finn A, Bagrade L, et al. (2008) Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathogens 4: e1000159.
41. Mai J, Wang H, Yang XF, Mai J, Wang H, et al. (2010) Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity. Front Biosci 15: 986-1006.
42. Kinter A, McNally J, Riggin L, Jackson R, Roby G, et al. (2007) Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals. Proc Natl Acad Sci USA 104: 3390-3395.
43. Sakaguchi S, Sakaguchi S, (2003) Regulatory T cells: mediating compromises between host and parasite. Nat Immunol 4: 10-11.