Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 3, 2013, Pages

  Kücüksezer, Umut Can ^a,b   Palomares, Oscar ^a,c   Rückert, Beate ^a   Jartti, Tuomas ^d   Puhakka, Tuomo ^d,e   Nandy, Andreas ^f   Gemicioǧlu, Bilun ^g   Fahrner, Heinz B ^h   Jung, Andreas ^a,i   Deniz, Günnur ^b   Akdis, Cezmi A ^a   Akdis, Mübeccel ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ISTANBUL UNIVERSITY   (Turkey)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e SATAKUNTA CENTRAL HOSPITAL   (Finland)

^f ALLERGOPHARMA JOACHIM GANZER KG   (Germany)

^g ISTANBUL UNIVERSITY   (Turkey)

^h KANTONSSPITAL GRAUBÜNDEN   (Switzerland)

ⁱ Hochgebirgsklinik   (Switzerland)

Author keywords

allergen specific T cells; IL 1 ; IL 6; myeloid dendritic cells; Peripheral tolerance; proinflammatory cytokines; Toll like receptors; tonsils

Indexed keywords

ALLERGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC DISEASE; ARTICLE; ATOPY; BLOOD; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMETRY; DISEASE EXACERBATION; DNA SYNTHESIS; EXPERIMENTAL MODEL; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; INFECTION; INFLAMMATION; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MYELOID DENDRITIC CELL; PALATINE TONSIL; PLASMACYTOID DENDRITIC CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SUPERNATANT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TH2 CELL;

EID: 84875215683     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.10.051     Document Type: Article

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