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Volumn 111, Issue 6, 2014, Pages 2253-2258

C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion

Author keywords

CSR synapse; DNA repair

Indexed keywords

CSR SYNAPSE; DNA REPAIR;

EID: 84893852373     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1324057111     Document Type: Article
Times cited : (23)

References (49)
  • 1
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102(5):553-563.
    • (2000) Cell , vol.102 , Issue.5 , pp. 553-563
    • Muramatsu, M.1
  • 2
    • 0037076967 scopus 로고    scopus 로고
    • AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
    • Yoshikawa K, et al. (2002) AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 296(5575):2033-2036.
    • (2002) Science , vol.296 , Issue.5575 , pp. 2033-2036
    • Yoshikawa, K.1
  • 3
    • 0037083364 scopus 로고    scopus 로고
    • Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
    • Arakawa H, Hauschild J, Buerstedde JM (2002) Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 295(5558): 1301-1306.
    • (2002) Science , vol.295 , Issue.5558 , pp. 1301-1306
    • Arakawa, H.1    Hauschild, J.2    Buerstedde, J.M.3
  • 4
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    • Revy P, et al. (2000) Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102(5):565-575.
    • (2000) Cell , vol.102 , Issue.5 , pp. 565-575
    • Revy, P.1
  • 5
    • 0037149473 scopus 로고    scopus 로고
    • The AID enzyme induces class switch recombination in fibroblasts
    • Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T (2002) The AID enzyme induces class switch recombination in fibroblasts. Nature 416(6878):340-345.
    • (2002) Nature , vol.416 , Issue.6878 , pp. 340-345
    • Okazaki, I.M.1    Kinoshita, K.2    Muramatsu, M.3    Yoshikawa, K.4    Honjo, T.5
  • 6
    • 29644440411 scopus 로고    scopus 로고
    • Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations
    • Saribasak H, et al. (2006) Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations. J Immunol 176(1):365-371.
    • (2006) J Immunol , vol.176 , Issue.1 , pp. 365-371
    • Saribasak, H.1
  • 7
    • 0141992113 scopus 로고    scopus 로고
    • Cterminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
    • Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC (2003) Cterminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 12(2):501-508.
    • (2003) Mol Cell , vol.12 , Issue.2 , pp. 501-508
    • Barreto, V.1    Reina-San-Martin, B.2    Ramiro, A.R.3    McBride, K.M.4    Nussenzweig, M.C.5
  • 8
    • 62449089909 scopus 로고    scopus 로고
    • The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
    • Doi T, et al. (2009) The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination. Proc Natl Acad Sci USA 106(8):2758-2763.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.8 , pp. 2758-2763
    • Doi, T.1
  • 9
    • 3242795967 scopus 로고    scopus 로고
    • Separate domains of AID are required for somatic hypermutation and class-switch recombination
    • Shinkura R, et al. (2004) Separate domains of AID are required for somatic hypermutation and class-switch recombination. Nat Immunol 5(7):707-712.
    • (2004) Nat Immunol , vol.5 , Issue.7 , pp. 707-712
    • Shinkura, R.1
  • 10
    • 0035818990 scopus 로고    scopus 로고
    • AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
    • Petersen S, et al. (2001) AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 414(6864):660-665.
    • (2001) Nature , vol.414 , Issue.6864 , pp. 660-665
    • Petersen, S.1
  • 11
    • 77649267656 scopus 로고    scopus 로고
    • Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70
    • Boboila C, et al. (2010) Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci USA 107(7):3034-3039.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.7 , pp. 3034-3039
    • Boboila, C.1
  • 12
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical end-joining pathway
    • Yan CT, et al. (2007) IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449(7161):478-482.
    • (2007) Nature , vol.449 , Issue.7161 , pp. 478-482
    • Yan, C.T.1
  • 13
    • 77950466186 scopus 로고    scopus 로고
    • NHEJ and its backup pathways in chromosomal translocations
    • Lieber MR (2010) NHEJ and its backup pathways in chromosomal translocations. Nat Struct Mol Biol 17(4):393-395.
    • (2010) Nat Struct Mol Biol , vol.17 , Issue.4 , pp. 393-395
    • Lieber, M.R.1
  • 14
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber MR (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79:181-211.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 15
    • 0035974862 scopus 로고    scopus 로고
    • Ablation of XRCC2/ 3 transforms immunoglobulin v gene conversion into somatic hypermutation
    • Sale JE, Calandrini DM, Takata M, Takeda S, Neuberger MS (2001) Ablation of XRCC2/ 3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature 412(6850):921-926.
    • (2001) Nature , vol.412 , Issue.6850 , pp. 921-926
    • Sale, J.E.1    Calandrini, D.M.2    Takata, M.3    Takeda, S.4    Neuberger, M.S.5
  • 16
    • 0041381361 scopus 로고    scopus 로고
    • AID mutant analyses indicate requirement for class-switch-specific cofactors
    • Ta VT, et al. (2003) AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat Immunol 4(9):843-848.
    • (2003) Nat Immunol , vol.4 , Issue.9 , pp. 843-848
    • Ta, V.T.1
  • 17
    • 1242341972 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide
    • Ito S, et al. (2004) Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide. Proc Natl Acad Sci USA 101(7):1975-1980
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.7 , pp. 1975-1980
    • Ito, S.1
  • 18
    • 57349135239 scopus 로고    scopus 로고
    • Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
    • Shivarov V, Shinkura R, Honjo T (2008) Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants. Proc Natl Acad Sci USA 105(41): 15866-15871.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.41 , pp. 15866-15871
    • Shivarov, V.1    Shinkura, R.2    Honjo, T.3
  • 19
    • 84858395631 scopus 로고    scopus 로고
    • The AID dilemma: Infection, or cancer?
    • Honjo T, et al. (2012) The AID dilemma: Infection, or cancer? Adv Cancer Res 113:1-44.
    • (2012) Adv Cancer Res , vol.113 , pp. 1-44
    • Honjo, T.1
  • 20
    • 66149087337 scopus 로고    scopus 로고
    • The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence
    • Geisberger R, Rada C, Neuberger MS (2009) The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence. Proc Natl Acad Sci USA 106(16):6736-6741.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.16 , pp. 6736-6741
    • Geisberger, R.1    Rada, C.2    Neuberger, M.S.3
  • 21
    • 78851468849 scopus 로고    scopus 로고
    • The dependence of Ig classswitching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin
    • Ellyard JI, Benk AS, Taylor B, Rada C, Neuberger MS (2011) The dependence of Ig classswitching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin. Eur J Immunol 41(2):485-490.
    • (2011) Eur J Immunol , vol.41 , Issue.2 , pp. 485-490
    • Ellyard, J.I.1    Benk, A.S.2    Taylor, B.3    Rada, C.4    Neuberger, M.S.5
  • 22
    • 62449280955 scopus 로고    scopus 로고
    • Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
    • Nonaka T, et al. (2009) Carboxy-terminal domain of AID required for its mRNA complex formation in vivo. Proc Natl Acad Sci USA 106(8):2747-2751.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.8 , pp. 2747-2751
    • Nonaka, T.1
  • 23
    • 84867386682 scopus 로고    scopus 로고
    • Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
    • Boboila C, Alt FW, Schwer B (2012) Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol 116:1-49.
    • (2012) Adv Immunol , vol.116 , pp. 1-49
    • Boboila, C.1    Alt, F.W.2    Schwer, B.3
  • 24
    • 0034612308 scopus 로고    scopus 로고
    • The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
    • Ferguson DO, et al. (2000) The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 97(12):6630-6633.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.12 , pp. 6630-6633
    • Ferguson, D.O.1
  • 25
    • 78650674433 scopus 로고    scopus 로고
    • Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair
    • Kracker S, et al. (2010) Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair. Proc Natl Acad Sci USA 107(51):22225-22230.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.51 , pp. 22225-22230
    • Kracker, S.1
  • 26
    • 66049143898 scopus 로고    scopus 로고
    • Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination
    • Robert I, Dantzer F, Reina-San-Martin B (2009) Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination. J Exp Med 206(5):1047-1056.
    • (2009) J Exp Med , vol.206 , Issue.5 , pp. 1047-1056
    • Robert, I.1    Dantzer, F.2    Reina-San-Martin, B.3
  • 27
    • 0034720734 scopus 로고    scopus 로고
    • Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1
    • Dantzer F, et al. (2000) Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. Biochemistry 39(25):7559-7569.
    • (2000) Biochemistry , vol.39 , Issue.25 , pp. 7559-7569
    • Dantzer, F.1
  • 28
    • 0027253141 scopus 로고
    • Overproduction of the poly(ADP-ribose) polymerase DNAbinding domain blocks alkylation-induced DNA repair synthesis in mammalian cells
    • Molinete M, et al. (1993) Overproduction of the poly(ADP-ribose) polymerase DNAbinding domain blocks alkylation-induced DNA repair synthesis in mammalian cells. EMBO J 12(5):2109-2117.
    • (1993) EMBO J , vol.12 , Issue.5 , pp. 2109-2117
    • Molinete, M.1
  • 29
    • 79951815075 scopus 로고    scopus 로고
    • Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining
    • Eccleston J, Yan C, Yuan K, Alt FW, Selsing E (2011) Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining. J Immunol 186(4):2336-2343.
    • (2011) J Immunol , vol.186 , Issue.4 , pp. 2336-2343
    • Eccleston, J.1    Yan, C.2    Yuan, K.3    Alt, F.W.4    Selsing, E.5
  • 30
    • 36148940618 scopus 로고    scopus 로고
    • S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase
    • Wuerffel R, et al. (2007) S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity 27(5):711-722.
    • (2007) Immunity , vol.27 , Issue.5 , pp. 711-722
    • Wuerffel, R.1
  • 31
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNAdependent protein kinase
    • DeFazio LG, Stansel RM, Griffith JD, Chu G (2002) Synapsis of DNA ends by DNAdependent protein kinase. EMBO J 21(12):3192-3200.
    • (2002) EMBO J , vol.21 , Issue.12 , pp. 3192-3200
    • Defazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 32
    • 84876855215 scopus 로고    scopus 로고
    • RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
    • Chapman JR, et al. (2013) RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell 49(5): 858-871.
    • (2013) Mol Cell , vol.49 , Issue.5 , pp. 858-871
    • Chapman, J.R.1
  • 33
    • 84873526612 scopus 로고    scopus 로고
    • Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching
    • Di Virgilio M, et al. (2013) Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 339(6120):711-715.
    • (2013) Science , vol.339 , Issue.6120 , pp. 711-715
    • Di Virgilio, M.1
  • 34
    • 84873488846 scopus 로고    scopus 로고
    • 53BP1 regulates DSB repair using Rif1 to control 5' end resection
    • Zimmermann M, Lottersberger F, Buonomo SB, Sfeir A, de Lange T (2013) 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science 339(6120): 700-704.
    • (2013) Science , vol.339 , Issue.6120 , pp. 700-704
    • Zimmermann, M.1    Lottersberger, F.2    Buonomo, S.B.3    Sfeir, A.4    De Lange, T.5
  • 35
    • 77951057068 scopus 로고    scopus 로고
    • 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
    • Bothmer A, et al. (2010) 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med 207(4):855-865.
    • (2010) J Exp Med , vol.207 , Issue.4 , pp. 855-865
    • Bothmer, A.1
  • 36
    • 57049124828 scopus 로고    scopus 로고
    • 53BP1 facilitates long-range DNA end-joining during v (D)J recombination
    • Difilippantonio S, et al. (2008) 53BP1 facilitates long-range DNA end-joining during V (D)J recombination. Nature 456(7221):529-533.
    • (2008) Nature , vol.456 , Issue.7221 , pp. 529-533
    • Difilippantonio, S.1
  • 37
    • 80052678086 scopus 로고    scopus 로고
    • AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus
    • Ranjit S, et al. (2011) AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus. J Immunol 187(5):2464-2475.
    • (2011) J Immunol , vol.187 , Issue.5 , pp. 2464-2475
    • Ranjit, S.1
  • 38
    • 59249084046 scopus 로고    scopus 로고
    • Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes
    • Nakahara M, et al. (2009) Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes. PLoS Genet 5(1):e1000356.
    • (2009) PLoS Genet , vol.5 , Issue.1
    • Nakahara, M.1
  • 39
    • 33845670454 scopus 로고    scopus 로고
    • NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: Evidence for a double strand break intermediate
    • Tang ES, Martin A (2006) NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: Evidence for a double strand break intermediate. Nucleic Acids Res 34(21):6345-6351.
    • (2006) Nucleic Acids Res , vol.34 , Issue.21 , pp. 6345-6351
    • Tang, E.S.1    Martin, A.2
  • 40
    • 34247349023 scopus 로고    scopus 로고
    • DNA-dependent protein kinase inhibits AID-induced antibody gene conversion
    • Cook AJ, et al. (2007) DNA-dependent protein kinase inhibits AID-induced antibody gene conversion. PLoS Biol 5(4):e80.
    • (2007) PLoS Biol , vol.5 , Issue.4
    • Cook, A.J.1
  • 41
    • 76049125030 scopus 로고    scopus 로고
    • AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
    • Kobayashi M, et al. (2009) AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination. Proc Natl Acad Sci USA 106(52):22375-22380.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.52 , pp. 22375-22380
    • Kobayashi, M.1
  • 42
    • 82755190634 scopus 로고    scopus 로고
    • Decrease in topoisomerase i is responsible for activationinduced cytidine deaminase (AID)-dependent somatic hypermutation
    • Kobayashi M, et al. (2011) Decrease in topoisomerase I is responsible for activationinduced cytidine deaminase (AID)-dependent somatic hypermutation. Proc Natl Acad Sci USA 108(48):19305-19310.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.48 , pp. 19305-19310
    • Kobayashi, M.1
  • 43
    • 10744233671 scopus 로고    scopus 로고
    • Repair of and checkpoint response to topoisomerase I-mediated DNA damage
    • Pommier Y, et al. (2003) Repair of and checkpoint response to topoisomerase I-mediated DNA damage. Mutat Res 532(1-2):173-203.
    • (2003) Mutat Res , vol.532 , Issue.1-2 , pp. 173-203
    • Pommier, Y.1
  • 44
    • 79956053314 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
    • Zhang YW, et al. (2011) Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res 39(9):3607-3620.
    • (2011) Nucleic Acids Res , vol.39 , Issue.9 , pp. 3607-3620
    • Zhang, Y.W.1
  • 45
    • 70350502118 scopus 로고    scopus 로고
    • Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks
    • Lin CP, Ban Y, Lyu YL, Liu LF (2009) Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks. J Biol Chem 284(41):28084-28092.
    • (2009) J Biol Chem , vol.284 , Issue.41 , pp. 28084-28092
    • Lin, C.P.1    Ban, Y.2    Lyu, Y.L.3    Liu, L.F.4
  • 46
    • 33846606769 scopus 로고    scopus 로고
    • Antibody class switching mediated by yeast endonucleasegenerated DNA breaks
    • Zarrin AA, et al. (2007) Antibody class switching mediated by yeast endonucleasegenerated DNA breaks. Science 315(5810):377-381.
    • (2007) Science , vol.315 , Issue.5810 , pp. 377-381
    • Zarrin, A.A.1
  • 47
    • 78449261906 scopus 로고    scopus 로고
    • Simultaneous disruption of two DNA polymerases, Pol and Pol, in Avian DT40 cells unmasks the role of Pol in cellular response to various DNA lesions
    • Hirota K, et al. (2010) Simultaneous disruption of two DNA polymerases, Pol and Pol, in Avian DT40 cells unmasks the role of Pol in cellular response to various DNA lesions. PLoS Genet 6(10):e1001151.
    • (2010) PLoS Genet , vol.6 , Issue.10
    • Hirota, K.1
  • 48
    • 70349483915 scopus 로고    scopus 로고
    • Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
    • Sabouri Z, et al. (2009) Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. Int Immunol 21(8):947-955.
    • (2009) Int Immunol , vol.21 , Issue.8 , pp. 947-955
    • Sabouri, Z.1
  • 49
    • 78650666372 scopus 로고    scopus 로고
    • Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
    • Stanlie A, Aida M, Muramatsu M, Honjo T, Begum NA (2010) Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination. Proc Natl Acad Sci USA 107(51): 22190-22195.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.51 , pp. 22190-22195
    • Stanlie, A.1    Aida, M.2    Muramatsu, M.3    Honjo, T.4    Begum, N.A.5


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