Melatonin attenuates memory impairment induced by klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential

International Journal of Neuropsychopharmacology

Volumn 18, Issue 6, 2015, Pages 1-14

  Shin, Eun Joo ^a   Chung, Yoon Hee ^b   Le, Hoang Lan Thi ^a   Jeong, Ji Hoon ^b   Dang, Duy Khanh ^a   Nam, Yunsung ^a   Wie, Myung Bok ^a   Nah, Seung Yeol ^c   Nabeshima, Yo Ichi ^d   Nabeshima, Toshitaka ^e   Kim, Hyoung Chun ^a  

^a Kangwon National University   (South Korea)

^b Chung Ang University   (South Korea)

^c Konkuk University   (South Korea)

^d INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^e MEIJO UNIVERSITY   (Japan)

Author keywords

Hippocampus; Klotho mutant mice; Melatonin MT2 receptor ERK Nrf2; Memory; Oxidative stress

Indexed keywords

ALPHA [AMINO(4 AMINOPHENYLTHIO)METHYLENE] 2 (TRIFLUOROMETHYL)PHENYLACETONITRILE; ANTIOXIDANT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; KLOTHO PROTEIN; MELATONIN; MELATONIN 2 RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; BETA GLUCURONIDASE; NFE2L2 PROTEIN, MOUSE; NOOTROPIC AGENT; PROTEIN KINASE INHIBITOR;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC MODEL; HIPPOCAMPUS; MEMORY DISORDER; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; AGONISTS; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; C3H MOUSE; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; MEMORY; MEMORY DISORDERS; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PSYCHOLOGY;

ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCURONIDASE; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HIPPOCAMPUS; MELATONIN; MEMORY; MEMORY DISORDERS; MICE, INBRED C3H; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; NOOTROPIC AGENTS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTOR, MELATONIN, MT2; SIGNAL TRANSDUCTION;

EID: 84939211434     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1093/ijnp/pyu105     Document Type: Article

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