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Volumn 64, Issue 1, 2013, Pages 1-7

A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease

Author keywords

Alzheimer' disease; Melatonin; Memory; Neu P11; Rats

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; MELATONIN; PIROMELATINE;

EID: 84878862568     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2013.04.009     Document Type: Article
Times cited : (95)

References (55)
  • 1
    • 0041817939 scopus 로고    scopus 로고
    • Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia
    • Asayama K., Yamadera H., Ito T., Suzuki H., Kudo Y., Endo S. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J. Nippon Med. Sch. 2003, 70:334-341.
    • (2003) J. Nippon Med. Sch. , vol.70 , pp. 334-341
    • Asayama, K.1    Yamadera, H.2    Ito, T.3    Suzuki, H.4    Kudo, Y.5    Endo, S.6
  • 3
    • 79960678522 scopus 로고    scopus 로고
    • When is the hippocampus involved in recognition memory?
    • Barker G.R., Warburton E.C. When is the hippocampus involved in recognition memory?. J. Neurosci. 2011, 31:10721-10731.
    • (2011) J. Neurosci. , vol.31 , pp. 10721-10731
    • Barker, G.R.1    Warburton, E.C.2
  • 4
    • 79952993584 scopus 로고    scopus 로고
    • Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat
    • Bertaina-Anglade V., Drieu-La-Rochelle C., Mocaër E., Seguin L. Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat. Pharmacol. Biochem. Behav. 2011, 98:511-517.
    • (2011) Pharmacol. Biochem. Behav. , vol.98 , pp. 511-517
    • Bertaina-Anglade, V.1    Drieu-La-Rochelle, C.2    Mocaër, E.3    Seguin, L.4
  • 5
    • 15744387176 scopus 로고    scopus 로고
    • Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid β-peptide (1-42) into rat brain: implications for Alzheimer's disease
    • Boyd-Kimball D., Sultana R., Poon H.F., Lynn B.C., Casamenti F. Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid β-peptide (1-42) into rat brain: implications for Alzheimer's disease. Neuroscience 2005, 132:313-324.
    • (2005) Neuroscience , vol.132 , pp. 313-324
    • Boyd-Kimball, D.1    Sultana, R.2    Poon, H.F.3    Lynn, B.C.4    Casamenti, F.5
  • 7
    • 8744276616 scopus 로고    scopus 로고
    • Amyloid beta-peptide (1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain
    • Butterfield D.A., Boyd-Kimball D. Amyloid beta-peptide (1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain. Brain Pathol. 2004, 14:426-432.
    • (2004) Brain Pathol. , vol.14 , pp. 426-432
    • Butterfield, D.A.1    Boyd-Kimball, D.2
  • 8
    • 39149131761 scopus 로고    scopus 로고
    • Aβ (1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT2A levels
    • Christensen R., Marcussen A.B., Wortwein G., Knudsen G.M., Aznar S. Aβ (1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT2A levels. Exp. Neurol. 2008, 210:164-171.
    • (2008) Exp. Neurol. , vol.210 , pp. 164-171
    • Christensen, R.1    Marcussen, A.B.2    Wortwein, G.3    Knudsen, G.M.4    Aznar, S.5
  • 11
    • 34247574175 scopus 로고    scopus 로고
    • The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
    • Dere E., Huston J.P., De Souza Silva M. The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents. Neurosci. Biobehav. Rev. 2007, 31:673-704.
    • (2007) Neurosci. Biobehav. Rev. , vol.31 , pp. 673-704
    • Dere, E.1    Huston, J.P.2    De Souza Silva, M.3
  • 12
    • 27644449587 scopus 로고    scopus 로고
    • Functional MT1 and MT2 melatonin receptors in mammals
    • Dubocovich M.L., Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine 2005, 27:101-110.
    • (2005) Endocrine , vol.27 , pp. 101-110
    • Dubocovich, M.L.1    Markowska, M.2
  • 13
    • 36949016215 scopus 로고    scopus 로고
    • Alzheimer disease models and human neuropathology: similarities and differences
    • Duyckaerts C., Potier M.C., Delatour B. Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol. 2008, 115:5-38.
    • (2008) Acta Neuropathol. , vol.115 , pp. 5-38
    • Duyckaerts, C.1    Potier, M.C.2    Delatour, B.3
  • 14
    • 28744450569 scopus 로고    scopus 로고
    • Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease
    • Feng Z., Qin C., Chang Y., Zhang J.T. Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease. Free Radic. Biol. Med. 2006, 40:101-109.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 101-109
    • Feng, Z.1    Qin, C.2    Chang, Y.3    Zhang, J.T.4
  • 18
    • 0035113872 scopus 로고    scopus 로고
    • The modulation of neuronal activity by melatonin: in vitro studies on mouse hippocampal slices
    • Hogan M.V., El-Sherif Y., Wieraszko A. The modulation of neuronal activity by melatonin: in vitro studies on mouse hippocampal slices. J. Pineal Res. 2001, 30:87-96.
    • (2001) J. Pineal Res. , vol.30 , pp. 87-96
    • Hogan, M.V.1    El-Sherif, Y.2    Wieraszko, A.3
  • 19
    • 62749169960 scopus 로고    scopus 로고
    • Altered angiotensin- converting enzyme and its effects on the brain in a rat model of Alzheimer disease
    • Hou D.R., Wang Y., Zhou L., Chen K., Tian Y., Song Z., Bao J., Yang Q.D. Altered angiotensin- converting enzyme and its effects on the brain in a rat model of Alzheimer disease. Chin. Med. J. (Engl.) 2008, 121:2320-2323.
    • (2008) Chin. Med. J. (Engl.) , vol.121 , pp. 2320-2323
    • Hou, D.R.1    Wang, Y.2    Zhou, L.3    Chen, K.4    Tian, Y.5    Song, Z.6    Bao, J.7    Yang, Q.D.8
  • 20
    • 4444304016 scopus 로고    scopus 로고
    • β-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex
    • Jhoo J.H., Kim H.C., Nabeshima T., Yamada K., Shin E.J., Jhoo W.K., Kim W., Kang K.S., Jo S.A., Woo J.I. β-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. Behav. Brain Res. 2004, 155:185-196.
    • (2004) Behav. Brain Res. , vol.155 , pp. 185-196
    • Jhoo, J.H.1    Kim, H.C.2    Nabeshima, T.3    Yamada, K.4    Shin, E.J.5    Jhoo, W.K.6    Kim, W.7    Kang, K.S.8    Jo, S.A.9    Woo, J.I.10
  • 21
    • 84155173414 scopus 로고    scopus 로고
    • Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation
    • Jobim P.F., Pedroso T.R., Werenicz A., Christoff R.R., Maurmann N., Reolon G.K., Schröder N., Roesler R. Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation. Behav. Brain Res. 2012, 228:151-158.
    • (2012) Behav. Brain Res. , vol.228 , pp. 151-158
    • Jobim, P.F.1    Pedroso, T.R.2    Werenicz, A.3    Christoff, R.R.4    Maurmann, N.5    Reolon, G.K.6    Schröder, N.7    Roesler, R.8
  • 23
    • 61349169762 scopus 로고    scopus 로고
    • Neu-P11, a novel melatonin agonist: effects on sleep and EEG power spectra in rats
    • Laudon M., Urade Y., Huang Z. Neu-P11, a novel melatonin agonist: effects on sleep and EEG power spectra in rats. Sleep 2008, 31(Suppl. A):34-35.
    • (2008) Sleep , vol.31 , Issue.SUPPL. A , pp. 34-35
    • Laudon, M.1    Urade, Y.2    Huang, Z.3
  • 24
    • 0032901972 scopus 로고    scopus 로고
    • Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease and apolipoprotein E-e4/4 genotype
    • Liu R.Y., Zhou J.N., van Heerikhuize J., Hofman M.A., Swaab D.F. Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease and apolipoprotein E-e4/4 genotype. J. Clin. Endocrinol. Metab. 1999, 84:323-327.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 323-327
    • Liu, R.Y.1    Zhou, J.N.2    van Heerikhuize, J.3    Hofman, M.A.4    Swaab, D.F.5
  • 25
    • 38049040002 scopus 로고    scopus 로고
    • Decreased nicotinic receptors and cognitive deficit in rats intracerebroventricularly injected with beta-amyloid peptide (1-42) and fed a high cholesterol diet
    • Liu R.Y., Gu R., Qi X.L., Zhang T., Zhao Y., He Y., Pei J.J., Guan Z.Z. Decreased nicotinic receptors and cognitive deficit in rats intracerebroventricularly injected with beta-amyloid peptide (1-42) and fed a high cholesterol diet. J. Neurosci. Res. 2008, 86:183-193.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 183-193
    • Liu, R.Y.1    Gu, R.2    Qi, X.L.3    Zhang, T.4    Zhao, Y.5    He, Y.6    Pei, J.J.7    Guan, Z.Z.8
  • 26
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 1997, 23:134-147.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 28
    • 53549105823 scopus 로고    scopus 로고
    • Relevance of abeta1-42 intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain
    • McLarnon J.G., Ryu J.K. Relevance of abeta1-42 intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain. Curr. Alzheimer Res. 2008, 5:475-480.
    • (2008) Curr. Alzheimer Res. , vol.5 , pp. 475-480
    • McLarnon, J.G.1    Ryu, J.K.2
  • 29
    • 35348886061 scopus 로고    scopus 로고
    • A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model
    • Munoz L., Ralay Ranaivo H., Roy S.M., Hu W., Craft J.M., McNamara L.K., Chico L.W., Van Eldik L.J., Watterson D.M. A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J. Neuroinflammation 2007, 4:21.
    • (2007) J. Neuroinflammation , vol.4 , pp. 21
    • Munoz, L.1    Ralay Ranaivo, H.2    Roy, S.M.3    Hu, W.4    Craft, J.M.5    McNamara, L.K.6    Chico, L.W.7    Van Eldik, L.J.8    Watterson, D.M.9
  • 30
    • 0036224536 scopus 로고    scopus 로고
    • Melatonin receptors in rat hippocampus: molecular and functional investigations
    • Musshoff U., Riewenherm D., Berger E., Fauteck J.D., Speckmann E.J. Melatonin receptors in rat hippocampus: molecular and functional investigations. Hippocampus 2002, 12:165-173.
    • (2002) Hippocampus , vol.12 , pp. 165-173
    • Musshoff, U.1    Riewenherm, D.2    Berger, E.3    Fauteck, J.D.4    Speckmann, E.J.5
  • 32
    • 67649905028 scopus 로고    scopus 로고
    • Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease
    • Olcese J.M., Cao C., Mori T., Mamcarz M.B., Maxwell A., Runfeldt M.J., Wang L., Zhang C., Lin X., Zhang G., Arendash G.W. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J. Pineal Res. 2009, 47:82-96.
    • (2009) J. Pineal Res. , vol.47 , pp. 82-96
    • Olcese, J.M.1    Cao, C.2    Mori, T.3    Mamcarz, M.B.4    Maxwell, A.5    Runfeldt, M.J.6    Wang, L.7    Zhang, C.8    Lin, X.9    Zhang, G.10    Arendash, G.W.11
  • 33
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-β-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
    • Palop J.J., Mucke L. Amyloid-β-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat. Neurosci. 2010, 13:812-818.
    • (2010) Nat. Neurosci. , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 36
    • 84867492240 scopus 로고    scopus 로고
    • Cardiovascular effects of melatonin receptor agonists
    • Paulis L., Simko F., Laudon M. Cardiovascular effects of melatonin receptor agonists. Expert Opin. Investig. Drugs 2012, 21:1661-1678.
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 1661-1678
    • Paulis, L.1    Simko, F.2    Laudon, M.3
  • 40
    • 84857184923 scopus 로고    scopus 로고
    • The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing
    • Rawashdeh O., Maronde E. The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing. Front. Mol. Neurosci. 2012, 5:27.
    • (2012) Front. Mol. Neurosci. , vol.5 , pp. 27
    • Rawashdeh, O.1    Maronde, E.2
  • 41
    • 36549083642 scopus 로고    scopus 로고
    • Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimers disease
    • Rojo L.E., Ferna'ndez J.A., Maccioni A.A., Jimenez J.M., Maccioni R.B. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimers disease. Arch. Med. Res. 2008, 39:1-16.
    • (2008) Arch. Med. Res. , vol.39 , pp. 1-16
    • Rojo, L.E.1    Ferna'ndez, J.A.2    Maccioni, A.A.3    Jimenez, J.M.4    Maccioni, R.B.5
  • 42
    • 7944233158 scopus 로고    scopus 로고
    • Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases
    • Selkoe D.J. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat. Cell Biol. 2004, 6:1054-1061.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1054-1061
    • Selkoe, D.J.1
  • 43
    • 61349142392 scopus 로고    scopus 로고
    • Neu-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats
    • She M., Deng X., Guo Z., Laudon M., Hu Z., Liao D., Hu X., Luo Y., Shen Q., Su Z., Yin W. Neu-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats. Pharmacol. Res. 2009, 59:248-253.
    • (2009) Pharmacol. Res. , vol.59 , pp. 248-253
    • She, M.1    Deng, X.2    Guo, Z.3    Laudon, M.4    Hu, Z.5    Liao, D.6    Hu, X.7    Luo, Y.8    Shen, Q.9    Su, Z.10    Yin, W.11
  • 44
  • 45
    • 0035200670 scopus 로고    scopus 로고
    • Interaction between synthetic amyloid-β-peptide (1-40) and its aggregation inhibitors studied by electrospray ionization mass spectrometry
    • Skribanek Z., Baláspiri L., Mák M. Interaction between synthetic amyloid-β-peptide (1-40) and its aggregation inhibitors studied by electrospray ionization mass spectrometry. J. Mass Spectrom. 2001, 36:1226-1229.
    • (2001) J. Mass Spectrom. , vol.36 , pp. 1226-1229
    • Skribanek, Z.1    Baláspiri, L.2    Mák, M.3
  • 48
    • 77954511022 scopus 로고    scopus 로고
    • Antidepressant-and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models
    • Tian S.W., Laudon M., Han L., Gao J., Huang F.L., Yang Y.F., Deng H.F. Antidepressant-and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models. Acta Pharmacol. Sin. 2010, 31:775-783.
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 775-783
    • Tian, S.W.1    Laudon, M.2    Han, L.3    Gao, J.4    Huang, F.L.5    Yang, Y.F.6    Deng, H.F.7
  • 50
    • 77949335521 scopus 로고    scopus 로고
    • The worldwide societal costs of dementia: estimates for 2009
    • Wimo A., Winblad B., Jönsson L. The worldwide societal costs of dementia: estimates for 2009. Alzheimers Dement. 2010, 6:98-103.
    • (2010) Alzheimers Dement. , vol.6 , pp. 98-103
    • Wimo, A.1    Winblad, B.2    Jönsson, L.3
  • 52
    • 79961172855 scopus 로고    scopus 로고
    • Phase-I study of the safety, tolerability, pharmacokinetics and sleep promoting activity of Neu-P11, a novel putative insomnia drug in healthy humans
    • (Abstract Supplement)
    • Yalkinoglu Ö., Zisapel N., Nir T., Piechatzek R., Schorr-Neufing U., Bitterlich N., Allgaier C., Oertel R., Kluge A., Laudon M. Phase-I study of the safety, tolerability, pharmacokinetics and sleep promoting activity of Neu-P11, a novel putative insomnia drug in healthy humans. Sleep 2010, 33:A220. (Abstract Supplement).
    • (2010) Sleep , vol.33
    • Yalkinoglu, Ö.1    Zisapel, N.2    Nir, T.3    Piechatzek, R.4    Schorr-Neufing, U.5    Bitterlich, N.6    Allgaier, C.7    Oertel, R.8    Kluge, A.9    Laudon, M.10
  • 53
    • 0032898672 scopus 로고    scopus 로고
    • Protective effects of idebenone and α-tocopherol on β-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo
    • Yamada K., Tanaka T., Han D., Senzaki K., Kameyama T., Nabeshima T. Protective effects of idebenone and α-tocopherol on β-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo. Eur. J. Neurosci. 1999, 11:83-90.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 83-90
    • Yamada, K.1    Tanaka, T.2    Han, D.3    Senzaki, K.4    Kameyama, T.5    Nabeshima, T.6
  • 55
    • 0042090064 scopus 로고    scopus 로고
    • Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels
    • Zhou J.N., Liu R.Y., Kamphorst W., Hofman M.A., Swaab D. Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J. Pineal Res. 2003, 35:125-130.
    • (2003) J. Pineal Res. , vol.35 , pp. 125-130
    • Zhou, J.N.1    Liu, R.Y.2    Kamphorst, W.3    Hofman, M.A.4    Swaab, D.5


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