Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment

Journal of Neuroscience Research

Volumn 87, Issue 16, 2009, Pages 3658-3670

  Jin, Chun Hui ^a   Shin, Eun Joo ^a   Park, Jae Bong ^b   Jang, Choon Gon ^c   Li, Zhengyi ^a   Kim, Min Soo ^a   Koo, Kyo Hwan ^a   Yoon, Hyoung Jong ^a   Park, Sang Jae ^d   Choi, Won Cheol ^e   Yamada, Kiyofumi ^f   Nabeshima, Toshitaka ^g   Kim, Hyoung Chun ^a  

^a Kangwon National University   (South Korea)

^b Hallym University   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d AZI Company Lt 319   (South Korea)

^e Kyung Hee University   (South Korea)

^f NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g MEIJO UNIVERSITY   (Japan)

Author keywords

amyloid; Fustin; Hippocampus; Learning and memory; Muscarinic M1 receptor

Indexed keywords

ACETYLCHOLINE; ALPHA [AMINO(4 AMINOPHENYLTHIO)METHYLENE] 2 (TRIFLUOROMETHYL)PHENYLACETONITRILE; AMYLOID BETA PROTEIN[1-42]; BRAIN DERIVED NEUROTROPHIC FACTOR; CHELERYTHRINE; CHOLINE ACETYLTRANSFERASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DICYCLOVERINE; FLAVONOID; FUSTIN; GINKGO BILOBA EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; MUSCARINIC M1 RECEPTOR; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNOPRECIPITATION; LEARNING DISORDER; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION;

ACETYLCHOLINE; AMINOACETONITRILE; AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; AUTORADIOGRAPHY; AVOIDANCE LEARNING; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHOLINE O-ACETYLTRANSFERASE; COGNITION; CONDITIONING, CLASSICAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DICYCLOMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEAR; FLAVONOIDS; HIPPOCAMPUS; IMMUNOPRECIPITATION; LEARNING; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCARINIC ANTAGONISTS; PEPTIDE FRAGMENTS; RECEPTOR, MUSCARINIC M1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 71249123562     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22159     Document Type: Article

References (52)

1. Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt JD. 1998. The MAPK cascade is required for mammalian associative learning. Nat Neurosci 1:602-609. (Pubitemid 128406370)
2. Berkeley JL, Gomeza J, Wess J, Hamilton SE, Nathanson NM, Levey AI. 2001. M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices. Mol Cell Neurosci 18:512-524 (Pubitemid 34008391)
3. Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM. 2006. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron 49:671-682. (Pubitemid 43290127)
4. Chao LP, Wolfgram F. 1972. Spectrophotometric assay for choline acetyltransferase. Anal Biochem 46:114-118.
5. Cheng YJ, Liu MY, Wu TP, Yang BC. 2004. Regulation of tumor necrosis factor-alpha in glioma cells by lead and lipopolysaccharide: involvement of common signaling pathway. Toxicol Lett 152:127-137.
6. Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, Dartigues JF. 2000. Intake of flavonoids and risk of dementia. Eur J Epidemiol 16:357-363.
7. Das A, Shanker G, Nath C, Pal R, Singh S, Singh H. 2002. A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: anticholinesterase and cognitive enhancing activities. Pharmacol Biochem Behav 73:893-900. (Pubitemid 35246239)
8. DeFeudis FV, Drieu K. 2000. Ginkgo biloba extract (EGb761) and CNS functions: basic studies and clinical applications. Curr Drug Targets 1:25-58.
9. English JD, Sweatt JD. 1996. Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J Biol Chem 271:24329-24332. (Pubitemid 26333160)
10. Fisher A. 2007. M1 muscarinic agonists target major hallmarks of Alzheimer's disease - an update. Curr Alzheimer Res 4:577-580. (Pubitemid 350248396)
11. Galeotti N, Ghelardini C, Bartolini A. 1998. Role of 5-HT4 receptors in the mouse passive avoidance test. J Pharmacol Exp Ther 286:1115-1121. (Pubitemid 29135518)
12. Gattu M, Pauly JR, Urbanawiz S, Buccafusco JJ. 1997. Autoradiographic comparison of muscarinic M1 and M2 binding sites in the CNS of spontaneously hypertensive and normotensive rats. Brain Res 771:173-183. (Pubitemid 27492095)
13. Genis I, Fisher A, Michaelson DM. 1999. Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment. J Neurochem 72:206-213. (Pubitemid 29013894)
14. Haring R, Fisher A, Marciano D, Pittel Z, Kloog Y, Zuckerman A, Eshhar N, Heldman E. 1998. Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion. J Neurochem 71:2094-2103. (Pubitemid 28491566)
15. Hendrie HC. 1997. Epidemiology of Alzheimer's disease. Geriatrics 52:S4-S8.
16. Jhoo JH, Kim HC, Nabeshima T, Yamada K, Shin EJ, Jhoo WK, Kim W, Kang KS, Jo SA, Woo JI. 2004. Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. Behav Brain Res 155:185-196. (Pubitemid 39208900)
17. 2-induced cytotoxicity in macrophage RAW 264.7 cell lines. Biol Pharm Bull 29:1603-1607.
18. Kihara T, Shimohama S, Urushitani M, Sawada H, Kimura J, Kume T, Maeda T, Akaike A. 1998. Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity. Brain Res 792:331-334. (Pubitemid 28267549)
19. Ko PC, Kilduff PT, Higgens JA, Milberg W, McGlinchey R. 2005. Evidence for intact selective attention in Alzheimer's disease patients using a location priming task. Neuropsychology 19:381-389. (Pubitemid 40727078)
20. Kurumatani T, Fastbom J, Bonkale WL, Bogdanovic N, Winblad B, Ohm TG, Cowburn RF. 1998. Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology. Brain Res 796:209-221. (Pubitemid 28343250)
21. Lee JC, Lim KT, Jang YS. 2002. Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochim Biophys Acta 1570:181-191.
22. Levey AI, Kitt CA, Simonds WF, Price DL, Brann MR. 1991. Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11:3218-3226.
23. Levin ED, Bradley A, Addy N, Sigurani N. 2002. Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Neuroscience 109:757-765. (Pubitemid 34260859)
24. Levites Y, Amit T, Youdim MB, Mandel S. 2002. Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action. J Biol Chem 277:30574-30580. (Pubitemid 34970751)
25. Levites Y, Amit T, Mandel S, Youdim MB. 2003. Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3- gallate. FASEB J 17:952-954.
26. Luikart BW, Nef S, Virmani T, Lush ME, Liu Y, Kavalali ET, Parada LF. 2005. TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J Neurosci 25:3774-3786. (Pubitemid 40570410)
27. Ma XH, Zhong P, Gu Z, Feng J, Yan Z. 2003. Muscarinic potentiation of GABA(A) receptor currents is gated by insulin signaling in the prefrontal cortex. J Neurosci 23:1159-1168. (Pubitemid 36258895)
28. Martinez A, Alcantara S, Borrell V, Del Rio JA, Blasi J, Otal R, Campos N, Boronat A, Barbacid M, Silos-Santiago I, Soriano E. 1998. TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections. J Neurosci 18:7336-7350. (Pubitemid 28425818)
29. Mulugeta E, Karlsson E, Islam A, Kalaria R, Mangat H, Winblad B, Adem A. 2003. Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients. Brain Res 960:259-262. (Pubitemid 36044584)
30. Nagai T, Yamada K, Kim HC, Kim YS, Noda Y, Imura A, Nabeshima Y, Nabeshima T. 2003. Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J 17:50-52.
31. Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D, Nakanishi Y, Murai M, Mizoguchi H, Nabeshima T, Yamada K. 2007. Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Learn Mem 14:117-125. (Pubitemid 46495188)
32. Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. 1992. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258:304-307.
33. Nitta A, Fukuta T, Hasegawa T, Nabeshima T. 1997. Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration. Jpn J Pharmacol 73:51-57. (Pubitemid 27078010)
34. Park BC, Lee YS, Park HJ, Kwak MK, Yoo BK, Kim JY, Kim JA. 2007. Protective effects of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-hydroxydopamine-induced neuronal cell death. Exp Mol Med 39:316-326.
35. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH. 2001. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22: 153-183. (Pubitemid 32458157)
36. Rossi C, Angelucci A, Costantin L, Braschi C, Mazzantini M, Babbini F, Fabbri ME, Tessarollo L, Maffei L, Berardi N, Caleo M. 2006. Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment. Eur J Neurosci 24:1850-1856. (Pubitemid 44583469)
37. Schulz V. 2003. Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trials and guidelines fail to consider. Phytomedicine 10(Suppl 4):74-79. (Pubitemid 36597162)
38. Shin EJ, Jhoo JH, Nabeshima T, Jhoo WK, Kwon MS, Lim YK, Chae JS, Jung ME, Park SJ, Jang KJ, Kim HC. 2005. Growth hormone releaser attenuates beta-amyloid (1-42)-induced memory impairment in mice. J Pharmacol Sci 99:117-120. (Pubitemid 41366900)
39. Shin EJ, Chae JS, Park SJ, Kim SC, Koo KH, Yamada K, Nabeshima T, Kim HC. 2009. Growth hormone-releaser diet attenuates beta-amyloid(1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice. J Pharmacol Sci 109:139-143.
40. 2+ channel currents in rat sensorimotor pyramidal cells via two distinct pathways. J Neurophysiol 81:72-84.
41. Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR. 1991. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 350:622-624. (Pubitemid 21912285)
42. Tong L, Balazs R, Thornton PL, Cotman CW. 2004. Beta-amyloid peptide at sublethal concentrations down-regulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci 24:6799-6809. (Pubitemid 38993902)
43. Trifilieff P, Herry C, Vanhoutte P, Caboche J, Desmedt A, Riedel G, Mons N, Micheau J. 2006. Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation. Learn Mem 13:349-358. (Pubitemid 43830682)
44. Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, Nomikos GG. 2003. Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry 8:673-679. (Pubitemid 36980624)
45. Valjent E, Corvol JC, Trzaskos JM, Girault JA, Herve D. 2006. Role of the ERK pathway in psychostimulant-induced locomotor sensitization. BMC Neurosci 7:20.
46. Walz C, Jungling K, Lessmann V, Gottmann K. 2006. Presynaptic plasticity in an immature neocortical network requires NMDA receptor activation and BDNF release. J Neurophysiol 96:3512-3516. (Pubitemid 44837892)
47. Wang HY, Pisano MR, Friedman E. 1994. Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol Aging 15:293-298. (Pubitemid 24194869)
48. Wang Y, Wang L, Wu J, Cai J. 2006. The in vivo synaptic plasticity mechanism of EGb761-induced enhancement of spatial learning and memory in aged rats. Br J Pharmacol 148:147-153. (Pubitemid 43873033)
49. Wolf BA, Wertkin AM, Jolly YC, Yasuda RP, Wolfe BB, Konrad RJ, Manning D, Ravi S, Williamson JR, Lee VM. 1995. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells. J Biol Chem 270:4916-4922.
50. Yamada K, Tanaka T, Han D, Senzaki K, Kameyama T, Nabeshima T. 1999. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)- induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci 11:83-90. (Pubitemid 29012313)
51. Yan JJ, Cho JY, Kim HS, Kim KL, Jung JS, Huh SO, Suh HW, Kim YH, Song DK. 2001. Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid. Br J Pharmacol 133:89-96.
52. Zhang LC, Buccafusco JJ. 2000. Adaptive changes in M1 muscarinic receptors localized to specific rostral brain regions during and after morphine withdrawal. Neuropharmacology 39:1720-1731.