Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2

European Journal of Pharmaceutical Sciences

Volumn 78, Issue , 2015, Pages 214-224

  Shen, Chenlin ^a   Chen, Ruonan ^a   Qian, Zhengyue ^a   Meng, Xiaoming ^a   Hu, Tingting ^a   Li, Yangyang ^a   Chen, Zhaolin ^a   Huang, Cheng ^a   Hu, Chaojie ^a,b   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b ANHUI PROVINCIAL HOSPITAL   (China)

Author keywords

Caco 2 cells; Flavonoids; MCT1; MRP2; MTBH; Passive diffusion

Indexed keywords

1,2,3,4,6,7,12,12A OCTAHYDRO 6 ISOBUTYL 9 METHOXY 1,4 DIOXOPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 3 PROPANOIC ACID TERT BUTYL ESTER; 8 METHYLENE TERT BUTYLAMINE 3',5,7 TRIHYDROXY 4' METHOXYFLAVANONE; ANTIINFLAMMATORY AGENT; BENZOIC ACID; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; FLAVONE DERIVATIVE; HESPERETIN; HESPERIDIN; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 3; MONOCARBOXYLATE TRANSPORTER 4; MONOCARBOXYLATE TRANSPORTER 6; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; PEPTIDE TRANSPORTER 1; PHLORETIN; PHLORIZIN; PROBENECID; QUERCETIN; SMALL INTERFERING RNA; SODIUM AZIDE; SODIUM GLUCOSE COTRANSPORTER 1; UNCLASSIFIED DRUG; VERAPAMIL; VERLUKAST; 8-METHYLENE-TERT-BUTYLAMINE-3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE; FLAVANONE DERIVATIVE; MONOCARBOXYLATE TRANSPORTER; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CACO 2 CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; LIMIT OF QUANTITATION; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WESTERN BLOTTING; HUMAN; METABOLISM;

ANTI-INFLAMMATORY AGENTS; CACO-2 CELLS; FLAVANONES; HESPERIDIN; HUMANS; INTESTINAL ABSORPTION; MONOCARBOXYLIC ACID TRANSPORTERS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS;

EID: 84938948593     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.07.022     Document Type: Article

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