Single Dose Oral and Intravenous Pharmacokinetics and Tissue Distribution of a Novel Hesperetin Derivative MTBH in Rats

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 41, Issue 6, 2016, Pages 675-688

  Shen, Chenlin ^a   Qian, Zhengyue ^a   Chen, Ruonan ^a   Meng, Xiaoming ^a   Hu, Tingting ^a   Chen, Zhaolin ^a   Li, Yangyang ^a   Huang, Cheng ^a   Hu, Chaojie ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

8 METHYLENE TERT BUTYLAMINE 3',5,7 TRIHYDROXY 4' METHOXYFLAVANONE; DRUG METABOLITE; FLAVONE DERIVATIVE; UNCLASSIFIED DRUG; GLUCURONIDE; HESPERETIN; HESPERIDIN; PROTECTIVE AGENT; SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG TISSUE LEVEL; HEART; INTESTINE; KIDNEY; LIVER; LUNG; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MUSCLE; NONHUMAN; RAT; SINGLE DRUG DOSE; SPLEEN; STOMACH; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; BIOTRANSFORMATION; BLOOD; COMPARATIVE STUDY; DRUG STABILITY; HALF LIFE TIME; INTOXICATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; ORAL DRUG ADMINISTRATION; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CARBON TETRACHLORIDE POISONING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; GLUCURONIDES; HALF-LIFE; HESPERIDIN; INJECTIONS, INTRAVENOUS; MALE; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SULFATES; TISSUE DISTRIBUTION;

EID: 84938794120     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-015-0293-2     Document Type: Article

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