메뉴 건너뛰기




Volumn 32, Issue 1, 2011, Pages 16-24

The membrane transport of flavonoids from Crossostephium chinense across the Caco-2 monolayer

Author keywords

Caco 2; efflux; flavonoids; MRP; selagin

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOMETZGERIN; ATENOLOL; CENTAUREIDIN; FLAVONOID; HISPIDULIN; MULTIDRUG RESISTANCE PROTEIN; QUERCETAGETIN; TRICETIN 3', 4', 5' TRIMETHYLETHER; UNCLASSIFIED DRUG;

EID: 78650413293     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.735     Document Type: Article
Times cited : (16)

References (40)
  • 1
    • 0026590679 scopus 로고
    • Inhibition of carcinogenesis by minor dietary constituents
    • Wattenberg LW,. Inhibition of carcinogenesis by minor dietary constituents. Cancer Res 1992; 52 (Suppl): 2085S-2091S.
    • (1992) Cancer Res , vol.52 , Issue.SUPPL.
    • Wattenberg, L.W.1
  • 2
    • 69949106198 scopus 로고    scopus 로고
    • Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy
    • Bansal T, Jaggi M, Khar RK, Talegaonkar S,. Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. J Pharm Sci 2009; 12: 46-78.
    • (2009) J Pharm Sci , vol.12 , pp. 46-78
    • Bansal, T.1    Jaggi, M.2    Khar, R.K.3    Talegaonkar, S.4
  • 3
    • 12744256734 scopus 로고    scopus 로고
    • Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance protein 1 and 2
    • van Zanden JJ, Wortelboer HM, Bijlsma S, et al,. Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance protein 1 and 2. Biochem Pharmacol 2005; 69: 699-708.
    • (2005) Biochem Pharmacol , vol.69 , pp. 699-708
    • Van Zanden, J.J.1    Wortelboer, H.M.2    Bijlsma, S.3
  • 4
    • 69949099322 scopus 로고    scopus 로고
    • Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives
    • Wong IL, Chan KF, Tsang KH, et al,. Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. J Med Chem 2009; 52: 5311-5322.
    • (2009) J Med Chem , vol.52 , pp. 5311-5322
    • Wong, I.L.1    Chan, K.F.2    Tsang, K.H.3
  • 5
    • 77955671379 scopus 로고    scopus 로고
    • Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo
    • DOI: 10.1002/bdd.717.
    • An G, Morris ME,. Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo. Biopharm Drug Dispos 2010; 31: 340-350. DOI: 10.1002/bdd.717.
    • (2010) Biopharm Drug Dispos , vol.31 , pp. 340-350
    • An, G.1    Morris, M.E.2
  • 6
    • 0030775534 scopus 로고    scopus 로고
    • Absorption, metabolism and health effects of dietary flavonoids in man
    • Hollman PCH, Katan MB,. Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 1997; 51: 305-310.
    • (1997) Biomed Pharmacother , vol.51 , pp. 305-310
    • Hollman, P.C.H.1    Katan, M.B.2
  • 7
    • 70349972154 scopus 로고    scopus 로고
    • Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats
    • Barve A, Chen C, Hebbar V, Desiderio J, Saw CL, Kong AN,. Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. Biopharm Drug Dispos 2009; 30: 356-365.
    • (2009) Biopharm Drug Dispos , vol.30 , pp. 356-365
    • Barve, A.1    Chen, C.2    Hebbar, V.3    Desiderio, J.4    Saw, C.L.5    Kong, A.N.6
  • 8
    • 1642528478 scopus 로고    scopus 로고
    • Absorption and metabolism of flavonoids
    • Walle T,. Absorption and metabolism of flavonoids. Free Radic Biol Med 2004; 36: 829-837.
    • (2004) Free Radic Biol Med , vol.36 , pp. 829-837
    • Walle, T.1
  • 9
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • Artursson PA, Karlsson J,. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 1991; 175: 880-885.
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 880-885
    • Artursson, P.A.1    Karlsson, J.2
  • 10
    • 67651166650 scopus 로고    scopus 로고
    • Absorption, conjugation and efflux of the flavonoids, kaempferol and galangin, using the intestinal Caco-2/TC7 cell model
    • Barrington R, Williamson G, Bennett RN, Davis BD, Brodbelt JS, Kroon PA,. Absorption, conjugation and efflux of the flavonoids, kaempferol and galangin, using the intestinal Caco-2/TC7 cell model. J Funct Food 2009; 1: 74-78.
    • (2009) J Funct Food , vol.1 , pp. 74-78
    • Barrington, R.1    Williamson, G.2    Bennett, R.N.3    Davis, B.D.4    Brodbelt, J.S.5    Kroon, P.A.6
  • 12
    • 33746867995 scopus 로고    scopus 로고
    • The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O- D -xylopyranosyl-(1→6)- D -glucopyranoside in the human intestinal cell line Caco-2
    • Tian XJ, Yang XD, Wang K, Yang XW,. The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O- D -xylopyranosyl-(1→6)- D -glucopyranoside in the human intestinal cell line Caco-2. Pharm Res 2006; 23: 1721-1728.
    • (2006) Pharm Res , vol.23 , pp. 1721-1728
    • Tian, X.J.1    Yang, X.D.2    Wang, K.3    Yang, X.W.4
  • 13
    • 58249119578 scopus 로고    scopus 로고
    • Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model
    • Tian XJ, Yang XW, Yang XD, Wang K,. Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model. Int J Pharm 2009; 367: 58-64.
    • (2009) Int J Pharm , vol.367 , pp. 58-64
    • Tian, X.J.1    Yang, X.W.2    Yang, X.D.3    Wang, K.4
  • 14
    • 0034671729 scopus 로고    scopus 로고
    • Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2
    • Murota K, Shimizu S, Chujo H, Moon JH, Terao J,. Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2. Arch Biochem Biophys 2000; 384: 391-397.
    • (2000) Arch Biochem Biophys , vol.384 , pp. 391-397
    • Murota, K.1    Shimizu, S.2    Chujo, H.3    Moon, J.H.4    Terao, J.5
  • 15
    • 0036302957 scopus 로고    scopus 로고
    • Unique uptake and transport of isoflavone aglycones by human intestinal Caco-2 cells: Comparison of isoflavonoids and flavonoids
    • Murota K, Shimizu S, Miyamoto S, et al,. Unique uptake and transport of isoflavone aglycones by human intestinal Caco-2 cells: comparison of isoflavonoids and flavonoids. J Nutr 2002; 132: 1956-1961.
    • (2002) J Nutr , vol.132 , pp. 1956-1961
    • Murota, K.1    Shimizu, S.2    Miyamoto, S.3
  • 16
    • 33644914487 scopus 로고    scopus 로고
    • Flavonoid-drug interactions: Effects of flavonoids on ABC transporters
    • Morris ME, Zhang SZ,. Flavonoid-drug interactions: effects of flavonoids on ABC transporters. Life Sci 2006; 78: 2116-2130.
    • (2006) Life Sci , vol.78 , pp. 2116-2130
    • Morris, M.E.1    Zhang, S.Z.2
  • 17
    • 0033051339 scopus 로고    scopus 로고
    • Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2
    • Walle UK, Galijatovic A, Walle T,. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol 1999; 58: 431-438.
    • (1999) Biochem Pharmacol , vol.58 , pp. 431-438
    • Walle, U.K.1    Galijatovic, A.2    Walle, T.3
  • 18
    • 0033020068 scopus 로고    scopus 로고
    • Transport of genistein-7-glucoside by human intestinal Caco-2 cells: Potential role for MRP2
    • Walle UK, French KL, Walgren RA, Walle T,. Transport of genistein-7-glucoside by human intestinal Caco-2 cells: Potential role for MRP2. Res Commun Mol Pathol Pharmacol 1999; 103: 45-56.
    • (1999) Res Commun Mol Pathol Pharmacol , vol.103 , pp. 45-56
    • Walle, U.K.1    French, K.L.2    Walgren, R.A.3    Walle, T.4
  • 19
    • 1542710231 scopus 로고    scopus 로고
    • Flavonoids and isoflavonoids: Absorption, metabolism, and bioactivity
    • Evans CR,. Flavonoids and isoflavonoids: Absorption, metabolism, and bioactivity. Life Sci 2003; 36: 827-828.
    • (2003) Life Sci , vol.36 , pp. 827-828
    • Evans, C.R.1
  • 20
    • 69749112905 scopus 로고    scopus 로고
    • Effects of chemical constituents of Crossostephium chinense on insulin secretion in rat islets in vitro
    • Zou L, Wu Q, Yang XW, Fu DX,. Effects of chemical constituents of Crossostephium chinense on insulin secretion in rat islets in vitro. Zhongguo Zhong Yao Za Zhi 2009; 34: 1401-1405.
    • (2009) Zhongguo Zhong Yao Za Zhi , vol.34 , pp. 1401-1405
    • Zou, L.1    Wu, Q.2    Yang, X.W.3    Fu, D.X.4
  • 21
    • 21344453042 scopus 로고    scopus 로고
    • Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells
    • Li WX, Cui CB, Cai B, Wang HY, Yao XS,. Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells. J Asian Nat Prod Res 2005; 7: 615-626.
    • (2005) J Asian Nat Prod Res , vol.7 , pp. 615-626
    • Li, W.X.1    Cui, C.B.2    Cai, B.3    Wang, H.Y.4    Yao, X.S.5
  • 23
    • 0031819211 scopus 로고    scopus 로고
    • Pharmacologically active components of viticis fructus (Vitex rotundifolia). I. The components having vascular relaxation effects
    • Okuyama E, Suzumura K, Yamazaki M,. Pharmacologically active components of Viticis Fructus (Vitex rotundifolia). I. The components having vascular relaxation effects. Nat Med 1998; 52: 218-225. (Pubitemid 28328140)
    • (1998) Natural Medicines , vol.52 , Issue.3 , pp. 218-225
    • Okuyama, E.1    Suzumura, K.2    Yamazaki, M.3
  • 24
    • 78650385859 scopus 로고    scopus 로고
    • Studies on the chemical constituents from the whole plants of Crossostephium chinense
    • Fu DX, Zou L, Yang XW,. Studies on the chemical constituents from the whole plants of Crossostephium chinense. Nat Prod Res Dev 2008; 20: 265-268.
    • (2008) Nat Prod Res Dev , vol.20 , pp. 265-268
    • Fu, D.X.1    Zou, L.2    Yang, X.W.3
  • 25
    • 0030023536 scopus 로고    scopus 로고
    • Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
    • Lennernas H, Palm K, Fagerholm U, Artursson P,. Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Int J Pharm 1996; 127: 103-107.
    • (1996) Int J Pharm , vol.127 , pp. 103-107
    • Lennernas, H.1    Palm, K.2    Fagerholm, U.3    Artursson, P.4
  • 26
    • 33847161645 scopus 로고    scopus 로고
    • Intestinal transport and metabolism of acrylamide
    • Zodl B, Schmid D, Wassler G, et al., Intestinal transport and metabolism of acrylamide. Toxicology 2007; 232: 99-108.
    • (2007) Toxicology , vol.232 , pp. 99-108
    • Zodl, B.1    Schmid, D.2    Wassler, G.3
  • 27
    • 0031455482 scopus 로고    scopus 로고
    • The P-glycoprotein efflux pump: How does it transport drugs?
    • Sharom FJ,. The P-glycoprotein efflux pump: how does it transport drugs? J Membr Biol 1997; 160: 161-175.
    • (1997) J Membr Biol , vol.160 , pp. 161-175
    • Sharom, F.J.1
  • 28
    • 0019430432 scopus 로고
    • Overcoming of vincristine resistance, in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
    • Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y,. Overcoming of vincristine resistance, in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 1981; 41: 1967-1972.
    • (1981) Cancer Res , vol.41 , pp. 1967-1972
    • Tsuruo, T.1    Iida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 29
    • 0346035033 scopus 로고    scopus 로고
    • Determination of thalidomide in transport buffer for Caco-2 cell monolayers by high-performance liquid chromatography with ultraviolet detection
    • Zhou SF, Li Y, Kestell P, Paxton JW,. Determination of thalidomide in transport buffer for Caco-2 cell monolayers by high-performance liquid chromatography with ultraviolet detection. J Chromatogr B 2003; 785: 165-173.
    • (2003) J Chromatogr B , vol.785 , pp. 165-173
    • Zhou, S.F.1    Li, Y.2    Kestell, P.3    Paxton, J.W.4
  • 30
    • 0029642277 scopus 로고
    • On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP)
    • Versantvoort CHM, Bagrij T, Wright KA, Twentyman PR,. On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP). Int J Cancer 1995; 63: 855-862.
    • (1995) Int J Cancer , vol.63 , pp. 855-862
    • Versantvoort, C.H.M.1    Bagrij, T.2    Wright, K.A.3    Twentyman, P.R.4
  • 31
    • 3242875643 scopus 로고    scopus 로고
    • The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects
    • Kavvadias D, Sand P, Youdim KA, et al,. The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br J Pharmacol 2004; 142: 811-820.
    • (2004) Br J Pharmacol , vol.142 , pp. 811-820
    • Kavvadias, D.1    Sand, P.2    Youdim, K.A.3
  • 32
    • 0033862088 scopus 로고    scopus 로고
    • Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines
    • Van Der Sandt ICJ, Blom-Roosemalen MCM, De Boer AG, Breimer DD,. Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. Eur J Pharm Sci 2000; 11: 207-214.
    • (2000) Eur J Pharm Sci , vol.11 , pp. 207-214
    • Van Der Sandt, I.C.J.1    Blom-Roosemalen, M.C.M.2    De Boer, A.G.3    Breimer, D.D.4
  • 33
    • 0032905375 scopus 로고    scopus 로고
    • Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake
    • Guttman H, Fricker G, Torok M, Michael S, Beglinger C, Drewe J,. Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake. Pharm Res 1999; 16: 402-407.
    • (1999) Pharm Res , vol.16 , pp. 402-407
    • Guttman, H.1    Fricker, G.2    Torok, M.3    Michael, S.4    Beglinger, C.5    Drewe, J.6
  • 34
    • 0033985306 scopus 로고    scopus 로고
    • Function and expression of multidrug resistance associated protein family in human colon adenocarcinoma cells (Caco-2)
    • Hirohashi T, Suzuki H, Chu XY, Tamai I, Tsuji A, Sugiyama Y,. Function and expression of multidrug resistance associated protein family in human colon adenocarcinoma cells (Caco-2). J Pharmacol Exp Ther 2000; 292: 265-270.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 265-270
    • Hirohashi, T.1    Suzuki, H.2    Chu, X.Y.3    Tamai, I.4    Tsuji, A.5    Sugiyama, Y.6
  • 35
    • 0034947674 scopus 로고    scopus 로고
    • From MDR to MXR: New understanding of multidrug resistance systems, their properties and clinical significance
    • Litman T, Druley TE, Stein WD, Bates SE,. From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cell Mol Life Sci 2001; 58: 931-959.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 931-959
    • Litman, T.1    Druley, T.E.2    Stein, W.D.3    Bates, S.E.4
  • 36
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • Konig JA, Nies T, Cui Y, Leier I, Keppler D,. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta 1999; 1461: 377-394.
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 377-394
    • Konig, J.A.1    Nies, T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 37
    • 34250004857 scopus 로고    scopus 로고
    • The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential
    • van Zanden JJ, van der Woude H, Vaessen J, et al,. The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential. Biochem Pharmacol 2007; 74: 345-351.
    • (2007) Biochem Pharmacol , vol.74 , pp. 345-351
    • Van Zanden, J.J.1    Van Der Woude, H.2    Vaessen, J.3
  • 38
    • 38549157279 scopus 로고    scopus 로고
    • Mrp2-related efflux of scutellarin in the intestinal absorption in rats
    • Cao F, Zhang H, Guo J, Ping Q,. Mrp2-related efflux of scutellarin in the intestinal absorption in rats. Pharmazie 2008; 63: 75-80.
    • (2008) Pharmazie , vol.63 , pp. 75-80
    • Cao, F.1    Zhang, H.2    Guo, J.3    Ping, Q.4
  • 39
    • 34548580164 scopus 로고    scopus 로고
    • Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: Transporter specificity and structure-activity relationship
    • Katayama K, Masuyama K, Yoshioka S, Hasegawa H, Mitsuhashi J, Sugimoto Y,. Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship. Cancer Chemother Pharmacol 2007; 60: 789-797.
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 789-797
    • Katayama, K.1    Masuyama, K.2    Yoshioka, S.3    Hasegawa, H.4    Mitsuhashi, J.5    Sugimoto, Y.6
  • 40
    • 34249297623 scopus 로고    scopus 로고
    • Mechanistic study on the intestinal absorption and disposition of baicalein
    • Zhang L, Lin G, Kovos B, Jani M, Krajcsi P, Zuo Z,. Mechanistic study on the intestinal absorption and disposition of baicalein. Eur J Pharm Sci 2007; 31: 221-231.
    • (2007) Eur J Pharm Sci , vol.31 , pp. 221-231
    • Zhang, L.1    Lin, G.2    Kovos, B.3    Jani, M.4    Krajcsi, P.5    Zuo, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.