메뉴 건너뛰기




Volumn 192, Issue 3, 2015, Pages 356-366

RNA sequencing analysis detection of a novel pathway of endothelial dysfunction in pulmonary arterial hypertension

(24)  Rhodes, Christopher J a,b,c   Im, Hogune b,c   Cao, Aiqin a,b,c   Hennigs, Jan K a,b,c   Wang, Lingli a,b,c   Sa, Silin a,b,c   Chen, Pin I a,b,c   Nickel, Nils P a,b,c   Miyagawa, Kazuya a,b,c   Hopper, Rachel K a,b,c   Tojais, Nancy F a,b,c   Li, Caiyun G a,b,c   Gu, Mingxia a,b,c   Spiekerkoetter, Edda a,b,d   Xian, Zhaoying a,b,c   Chen, Rui b,c   Zhao, Mingming b,c   Kaschwich, Mark a,b,c   Del Rosario, Patricia A a,b,d   Bernstein, Daniel b,c   more..


Author keywords

Collagen IV; Ephrin; Pulmonary hypertension; Transcriptome; Vascular endothelium

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 4; TRANSCRIPTOME; VASCULOTROPIN RECEPTOR; BMPR2 PROTEIN, HUMAN; BMPR2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN RECEPTOR 2;

EID: 84938889914     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201408-1528OC     Document Type: Article
Times cited : (68)

References (50)
  • 1
    • 84870523226 scopus 로고    scopus 로고
    • Molecular pathogenesis of pulmonary arterial hypertension
    • Rabinovitch M. Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 2012;122:4306-4313.
    • (2012) J Clin Invest , vol.122 , pp. 4306-4313
    • Rabinovitch, M.1
  • 2
    • 33644865928 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: Implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
    • Teichert-Kuliszewska K, Kutryk MJ, Kuliszewski MA, Karoubi G, Courtman DW, Zucco L, Granton J, Stewart DJ. Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ Res 2006;98:209-217.
    • (2006) Circ Res , vol.98 , pp. 209-217
    • Teichert-Kuliszewska, K.1    Kutryk, M.J.2    Kuliszewski, M.A.3    Karoubi, G.4    Courtman, D.W.5    Zucco, L.6    Granton, J.7    Stewart, D.J.8
  • 8
    • 0037046175 scopus 로고    scopus 로고
    • Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
    • Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation 2002;105:1672-1678.
    • (2002) Circulation , vol.105 , pp. 1672-1678
    • Atkinson, C.1    Stewart, S.2    Upton, P.D.3    Machado, R.4    Thomson, J.R.5    Trembath, R.C.6    Morrell, N.W.7
  • 11
    • 78650969170 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function
    • Burton VJ, Ciuclan LI, Holmes AM, Rodman DM, Walker C, Budd DC. Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function. Blood 2011;117:333-341.
    • (2011) Blood , vol.117 , pp. 333-341
    • Burton, V.J.1    Ciuclan, L.I.2    Holmes, A.M.3    Rodman, D.M.4    Walker, C.5    Budd, D.C.6
  • 14
    • 79953677802 scopus 로고    scopus 로고
    • Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension
    • Hsu E, Shi H, Jordan RM, Lyons-Weiler J, Pilewski JM, Feghali-Bostwick CA. Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension. Arthritis Rheum 2011;63:783-794.
    • (2011) Arthritis Rheum , vol.63 , pp. 783-794
    • Hsu, E.1    Shi, H.2    Jordan, R.M.3    Lyons-Weiler, J.4    Pilewski, J.M.5    Feghali-Bostwick, C.A.6
  • 16
  • 17
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 2009;10:57-63.
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 18
    • 67650188576 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
    • Upton PD, Davies RJ, Trembath RC, Morrell NW. Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J Biol Chem 2009;284:15794-15804.
    • (2009) J Biol Chem , vol.284 , pp. 15794-15804
    • Upton, P.D.1    Davies, R.J.2    Trembath, R.C.3    Morrell, N.W.4
  • 22
    • 80051532504 scopus 로고    scopus 로고
    • Down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4
    • Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem 2011;286: 28097-28110.
    • (2011) J Biol Chem , vol.286 , pp. 28097-28110
    • Davis-Dusenbery, B.N.1    Chan, M.C.2    Reno, K.E.3    Weisman, A.S.4    Layne, M.D.5    Lagna, G.6    Hata, A.7
  • 25
    • 77649270362 scopus 로고    scopus 로고
    • High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells
    • Du B, Ma LM, Huang MB, Zhou H, Huang HL, Shao P, Chen YQ, Qu LH. High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells. FEBS Lett 2010;584:811-816.
    • (2010) FEBS Lett , vol.584 , pp. 811-816
    • Du, B.1    Ma, L.M.2    Huang, M.B.3    Zhou, H.4    Huang, H.L.5    Shao, P.6    Chen, Y.Q.7    Qu, L.H.8
  • 26
    • 84905440289 scopus 로고    scopus 로고
    • miR-137 regulates the migration of human umbilical vein endothelial cells by targeting ephrin-type A receptor 7
    • Lu Y, Heng X, Yu J, Su Q, Guan X, You C, Wang L, Che F. miR-137 regulates the migration of human umbilical vein endothelial cells by targeting ephrin-type A receptor 7. Mol Med Rep 2014;10: 1475-1480.
    • (2014) Mol Med Rep , vol.10 , pp. 1475-1480
    • Lu, Y.1    Heng, X.2    Yu, J.3    Su, Q.4    Guan, X.5    You, C.6    Wang, L.7    Che, F.8
  • 27
    • 84902314338 scopus 로고    scopus 로고
    • HIF-1 alpha-induced up-regulation of miR-9 contributes to phenotypic modulation in pulmonary artery smooth muscle cells during hypoxia
    • Shan F, Li J, Huang QY. HIF-1 alpha-induced up-regulation of miR-9 contributes to phenotypic modulation in pulmonary artery smooth muscle cells during hypoxia. J Cell Physiol 2014;229:1511-1520.
    • (2014) J Cell Physiol , vol.229 , pp. 1511-1520
    • Shan, F.1    Li, J.2    Huang, Q.Y.3
  • 32
    • 84934440223 scopus 로고    scopus 로고
    • Gadd45 proteins: Key players of repair-mediated DNA demethylation
    • Schäfer A. Gadd45 proteins: key players of repair-mediated DNA demethylation. Adv Exp Med Biol 2013;793:35-50.
    • (2013) Adv Exp Med Biol , vol.793 , pp. 35-50
    • Schäfer, A.1
  • 33
    • 84884154169 scopus 로고    scopus 로고
    • An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation
    • Hohenhaus DM, Schaale K, Le Cao KA, Seow V, Iyer A, Fairlie DP, Sweet MJ. An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation. Immunobiology 2013;218: 1345-1353.
    • (2013) Immunobiology , vol.218 , pp. 1345-1353
    • Hohenhaus, D.M.1    Schaale, K.2    Le Cao, K.A.3    Seow, V.4    Iyer, A.5    Fairlie, D.P.6    Sweet, M.J.7
  • 34
    • 84856252361 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells
    • Nunes-Xavier CE, Elson A, Pulido R. Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells. J Biol Chem 2012; 287:3433-3444.
    • (2012) J Biol Chem , vol.287 , pp. 3433-3444
    • Nunes-Xavier, C.E.1    Elson, A.2    Pulido, R.3
  • 35
    • 84906329685 scopus 로고    scopus 로고
    • The high mobility group A1 molecular switch: Turning on cancer-can we turn it off?
    • Huso TH, Resar LM. The high mobility group A1 molecular switch: turning on cancer-can we turn it off? Expert Opin Ther Targets 2014; 18:541-553.
    • (2014) Expert Opin Ther Targets , vol.18 , pp. 541-553
    • Huso, T.H.1    Resar, L.M.2
  • 36
    • 79251546708 scopus 로고    scopus 로고
    • H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response
    • Viemann D, Schmolke M, Lueken A, Boergeling Y, Friesenhagen J, Wittkowski H, Ludwig S, Roth J. H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response. J Immunol 2011; 186:164-173.
    • (2011) J Immunol , vol.186 , pp. 164-173
    • Viemann, D.1    Schmolke, M.2    Lueken, A.3    Boergeling, Y.4    Friesenhagen, J.5    Wittkowski, H.6    Ludwig, S.7    Roth, J.8
  • 37
    • 78650880799 scopus 로고    scopus 로고
    • Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase
    • Zhang M, Song P, Xu J, Zou MH. Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol 2011;31:125-132.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 125-132
    • Zhang, M.1    Song, P.2    Xu, J.3    Zou, M.H.4
  • 38
    • 69249242832 scopus 로고    scopus 로고
    • Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo
    • Hein TW, Singh U, Vasquez-Vivar J, Devaraj S, Kuo L, Jialal I. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis 2009;206:61-68.
    • (2009) Atherosclerosis , vol.206 , pp. 61-68
    • Hein, T.W.1    Singh, U.2    Vasquez-Vivar, J.3    Devaraj, S.4    Kuo, L.5    Jialal, I.6
  • 39
    • 84907858757 scopus 로고    scopus 로고
    • Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension
    • Bakhshi FR, Mao M, Shajahan AN, Piegeler T, Chen Z, Chernaya O, Sharma T, Elliott WM, Szulcek R, Bogaard HJ, et al. Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ 2013;3:816-830.
    • (2013) Pulm Circ , vol.3 , pp. 816-830
    • Bakhshi, F.R.1    Mao, M.2    Shajahan, A.N.3    Piegeler, T.4    Chen, Z.5    Chernaya, O.6    Sharma, T.7    Elliott, W.M.8    Szulcek, R.9    Bogaard, H.J.10
  • 41
    • 84896545860 scopus 로고    scopus 로고
    • Basal PIR expression in HeLa cells is driven by NRF2 via evolutionary conserved antioxidant response element
    • Brzóska K, Stepkowski TM, Kruszewski M. Basal PIR expression in HeLa cells is driven by NRF2 via evolutionary conserved antioxidant response element. Mol Cell Biochem 2014; 389: 99-111.
    • (2014) Mol Cell Biochem , vol.389 , pp. 99-111
    • Brzóska, K.1    Stepkowski, T.M.2    Kruszewski, M.3
  • 44
    • 77957894168 scopus 로고    scopus 로고
    • Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line
    • Caccia D, Miccichè F, Cassinelli G, Mondellini P, Casalini P, Bongarzone I. Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line. Mol Cancer 2010;9:278.
    • (2010) Mol Cancer , vol.9 , pp. 278
    • Caccia, D.1    Miccichè, F.2    Cassinelli, G.3    Mondellini, P.4    Casalini, P.5    Bongarzone, I.6
  • 45
    • 39849084288 scopus 로고    scopus 로고
    • Implications of mutations of activin receptor-like kinase 1 gene (ALK1) in addition to bone morphogenetic protein receptor II gene (BMPR2) in children with pulmonary arterial hypertension
    • Fujiwara M, Yagi H, Matsuoka R, Akimoto K, Furutani M, Imamura S, Uehara R, Nakayama T, Takao A, Nakazawa M, et al. Implications of mutations of activin receptor-like kinase 1 gene (ALK1) in addition to bone morphogenetic protein receptor II gene (BMPR2) in children with pulmonary arterial hypertension. Circ J 2008;72:127-133.
    • (2008) Circ J , vol.72 , pp. 127-133
    • Fujiwara, M.1    Yagi, H.2    Matsuoka, R.3    Akimoto, K.4    Furutani, M.5    Imamura, S.6    Uehara, R.7    Nakayama, T.8    Takao, A.9    Nakazawa, M.10
  • 46
    • 0033785409 scopus 로고    scopus 로고
    • Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
    • Miao H, Burnett E, Kinch M, Simon E, Wang B. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat Cell Biol 2000;2:62-69.
    • (2000) Nat Cell Biol , vol.2 , pp. 62-69
    • Miao, H.1    Burnett, E.2    Kinch, M.3    Simon, E.4    Wang, B.5
  • 47
    • 0036045804 scopus 로고    scopus 로고
    • EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas)
    • Carter N, Nakamoto T, Hirai H, Hunter T. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol 2002;4:565-573.
    • (2002) Nat Cell Biol , vol.4 , pp. 565-573
    • Carter, N.1    Nakamoto, T.2    Hirai, H.3    Hunter, T.4
  • 48
    • 1842482987 scopus 로고    scopus 로고
    • Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development
    • Pöschl E, Schlötzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development 2004;131:1619-1628.
    • (2004) Development , vol.131 , pp. 1619-1628
    • Pöschl, E.1    Schlötzer-Schrehardt, U.2    Brachvogel, B.3    Saito, K.4    Ninomiya, Y.5    Mayer, U.6
  • 50
    • 27744597086 scopus 로고    scopus 로고
    • Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression
    • Brantley-Sieders DM, Fang WB, Hicks DJ, Zhuang G, Shyr Y, Chen J. Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J 2005;19: 1884-1886.
    • (2005) FASEB J , vol.19 , pp. 1884-1886
    • Brantley-Sieders, D.M.1    Fang, W.B.2    Hicks, D.J.3    Zhuang, G.4    Shyr, Y.5    Chen, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.