Elafin reverses pulmonary hypertension via caveolin-1-dependent bone morphogenetic protein signaling

American Journal of Respiratory and Critical Care Medicine

Volumn 191, Issue 11, 2015, Pages 1273-1286

  Nickel, Nils P ^a   Spiekerkoetter, Edda ^a   Gu, Mingxia ^a   Li, Caiyun G ^a   Li, Hai ^a   Kaschwich, Mark ^a   Diebold, Isabel ^a   Hennigs, Jan K ^a   Kim, Ki Yoon ^a   Miyagawa, Kazuya ^a   Wang, Lingli ^a   Cao, Aiqin ^a   Sa, Silin ^a   Jiang, Xinguo ^a   Stockstill, Raymond W ^a   Nicolls, Mark R ^a   Zamanian, Roham T ^a   Bland, Richard D ^a   Rabinovitch, Marlene ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apelin; Arterial smooth muscle cells; Endothelial cell apoptosis; Neutrophil elastase inhibition; Pulmonary vascular regeneration and angiogenesis

Indexed keywords

APELIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CAVEOLIN 1; ELAFIN; LEUKOCYTE ELASTASE; VASCULOTROPIN RECEPTOR; PANCREATIC ELASTASE; PROTEINASE INHIBITOR; TIPRELESTAT;

ADULT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; LUNG ENDOTHELIUM; MALE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DRUG EFFECTS; ENDOTHELIUM CELL; HYPERTENSION, PULMONARY; SMOOTH MUSCLE CELL;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CAVEOLIN 1; CELLS, CULTURED; ELAFIN; ENDOTHELIAL CELLS; HUMANS; HYPERTENSION, PULMONARY; MYOCYTES, SMOOTH MUSCLE; PANCREATIC ELASTASE; PROTEASE INHIBITORS; RATS; SIGNAL TRANSDUCTION;

EID: 84930464409     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201412-2291OC     Document Type: Article

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