Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1

Developmental Dynamics

Volumn 239, Issue 12, 2010, Pages 3226-3234

  Frieden, Leslie A ^a   Townsend, Todd A ^a   Vaught, David B ^a   Delaughter, Daniel M ^a   Hwang, Yoonha ^a   Barnett, Joey V ^a   Chen, Jin ^a,b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Eph receptor; Ephrin; Heart valve development

Indexed keywords

EPHRIN A1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA VALVE; ARTICLE; CELL TRANSFORMATION; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; GENE OVEREXPRESSION; HEART DEVELOPMENT; HEART FUNCTION; KNOCKOUT MOUSE; MESENCHYME CELL; MITRAL VALVE; MORPHOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; VALVULAR HEART DISEASE;

ANIMALS; ECHOCARDIOGRAPHY; EPHRIN-A1; FEMALE; HEART; HEART VALVES; MALE; MICE; MICE, KNOCKOUT; MORPHOGENESIS;

ANIMALIA; MUS;

EID: 78649688488     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22458     Document Type: Article

References (35)

1. Barnett JV, Desgrosellier JS. 2003. Early events in valvulogenesis: a signaling perspective. Birth Defects Res C Embryo Today 69: 58-72.
2. Bartram U, Molin DG, Wisse LJ, Mohamad A, Sanford LP, Doetschman T, Speer CP, Poelmann RE, Gittenberger-de Groot AC. 2001. Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice. Circulation 103: 2745-2752.
3. Brantley DM, Cheng N, Thompson EJ, Lin Q, Brekken RA, Thorpe PE, Muraoka RS, Cerretti DP, Pozzi A, Jackson D, Lin C, Chen J. 2002. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene 21: 7011-7026.
4. Brown CB, Feiner L, Lu MM, Li J, Ma X, Webber AL, Jia L, Raper JA, Epstein JA. 2001. PlexinA2 and semaphorin signaling during cardiac neural crest development. Development 128: 3071-3080.
5. Carter N, Nakamoto T, Hirai H, Hunter T. 2002. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol 4: 565-573.
6. Chen B, Bronson RT, Klaman LD, Hampton TG, Wang JF, Green PJ, Magnuson T, Douglas PS, Morgan JP, Neel BG. 2000. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 24: 296-299.
7. Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV. 1997. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 337: 581-588.
8. Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M. 2004. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol 271: 263-271.
9. Desgrosellier JS, Mundell NA, McDonnell MA, Moses HL, Barnett JV. 2005. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol 280: 201-210.
10. Erickson SL, O'Shea KS, Ghaboosi N, Loverro L, Frantz G, Bauer M, Lu LH, Moore MW. 1997. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124: 4999-5011.
11. Flagg AE, Earley JU, Svensson EC. 2007. FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Dev Biol 304: 308-316.
12. Flenniken AM, Gale NW, Yancopoulos GD, Wilkinson DG. 1996. Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. Dev Biol 179: 382-401.
13. Hoffman JI, Kaplan S, Liberthson RR. 2004. Prevalence of congenital heart disease. Am Heart J 147: 425-439.
14. Holzman LB, Marks RM, Dixit VM. 1990. A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Mol Cell Biol 10: 5830-5838.
15. Jackson LF, Qiu TH, Sunnarborg SW, Chang A, Zhang C, Patterson C, Lee DC. 2003. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. Embo J 22: 2704-2716.
16. Jiao K, Kulessa H, Tompkins K, Zhou Y, Batts L, Baldwin HS, Hogan BL. 2003. An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev 17: 2362-2367.
17. Macrae M, Neve RM, Rodriguez-Viciana P, Haqq C, Yeh J, Chen C, Gray JW, McCormick F. 2005. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell 8: 111-118.
18. Meberg A, Lindberg H, Thaulow E. 2005. Congenital heart defects: the patients who die. Acta Paediatr 94: 1060-1065.
19. Meyer D, Birchmeier C. 1995. Multiple essential functions of neuregulin in development. Nature 378: 386-390.
20. Misch KA. 1974. Development of heart valve lesions during methysergide therapy. Br Med J 2: 365-366.
21. Mylonakis E, Calderwood SB. 2001. Infective endocarditis in adults. N Engl J Med 345: 1318-1330.
22. Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB. 2000. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene 19: 6043-6052.
23. Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM. 1995. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science 268: 567-569.
24. Pasquale EB. 2005. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 6: 462-475.
25. Person AD, Klewer SE, Runyan RB. 2005. Cell biology of cardiac cushion development. Int Rev Cytol 243: 287-335.
26. Potts JD, Runyan RB. 1989. Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor beta. Dev Biol 134: 392-401.
27. Potts JD, Vincent EB, Runyan RB, Weeks DL. 1992. Sense and antisense TGF beta 3 mRNA levels correlate with cardiac valve induction. Dev Dyn 193: 340-345.
28. Robiolio PA, Rigolin VH, Wilson JS, Harrison JK, Sanders LL, Bashore TM, Feldman JM. 1995. Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography. Circulation 92: 790-795.
29. Ruiz JC, Robertson EJ. 1994. The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech Dev 46: 87-100.
30. Runyan RB, Markwald RR. 1983. Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissue. Dev Biol 95: 108-114.
31. Srivastava D. 2006. Genetic regulation of cardiogenesis and congenital heart disease. Annu Rev Pathol 1: 199-213.
32. Stephen LJ, Fawkes AL, Verhoeve A, Lemke G, Brown A. 2007. A critical role for the EphA3 receptor tyrosine kinase in heart development. Dev Biol 302: 66-79.
33. Timmerman LA, Grego-Bessa J, Raya A, Bertran E, Perez-Pomares JM, Diez J, Aranda S, Palomo S, McCormick F, Izpisua-Belmonte JC, de la Pompa JL. 2004. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev 18: 99-115.
34. Wilkins BJ, De Windt LJ, Bueno OF, Braz JC, Glascock BJ, Kimball TF, Molkentin JD. 2002. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol 22: 7603-7613.
35. Wilkinson DG. 2001. Multiple roles of EPH receptors and ephrins in neural development. Nat Rev Neurosci 2: 155-164.