Genomic approaches to research in pulmonary hypertension

Respiratory Research

Volumn 2, Issue 4, 2001, Pages 210-215

  Geraci, Mark W ^a   Gao, Bifeng ^a   Hoshikawa, Yasushi ^a   Yeager, Michael E ^a   Tuder, Rubin M ^b   Voelkel, Norbert F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genetic mutation; Knockout mouse; Microarray; Pulmonary hypertension; Transgenic mouse

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; FAMILIAL DISEASE; GENE DISRUPTION; GENE FUNCTION; GENE TARGETING; GENE TECHNOLOGY; GENETIC MANIPULATION; GENETIC SELECTION; GENOMICS; HUMAN; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PATHOLOGY; PULMONARY HYPERTENSION; REVIEW; TRANSGENICS;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION, PULMONARY; MICE; MICE, TRANSGENIC; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 0035721812     PISSN: 14659921     EISSN: None     Source Type: Journal    
DOI: 10.1186/rr59     Document Type: Review

References (34)

1. Executive summary from the World Symposium on primary pulmonary hypertension
2. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
3. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension
4. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
5. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
6. 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension
7. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
8. Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth
9. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats
10. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia
11. Prostacyclin receptor-dependent modulation of pulmonary vascular remodeling
12. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension
13. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor
14. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
15. Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats
16. Pulmonary prostacyclin synthase overexpression by adenovirus transfection and in transgenic mice
17. Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats
18. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer
19. Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension
20. Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection
21. Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family
22. BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension
23. TGF-β signaling in growth control, cancer, and heritable disorders
24. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
25. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
26. Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension
27. Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension
28. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
29. Genomic instability in the type II TGF-β1 receptor gene in atherosclerotic and restenotic vascular cells
30. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
31. Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension
32. Expression monitoring by hybridization to high-density oligonucleotide arrays
33. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
34. Gene expression patterns in the lungs of patients with primary pulmonary hypertension - A gene microarray analysis