Fine mapping of PPH1, a gene for familial primary pulmonary hypertension, to a 3-cM region on chromosome 2q33

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 3 I, 2000, Pages 1055-1059

  Deng, Zemin ^b   Haghighi, Fatemeh ^b   Helleby, Leticia ^b   Vanterpool, Kisha ^b   Horn, Evelyn M ^b   Barst, Robyn J ^b   Hodge, Susan E ^b   Morse, Jane H ^b   Knowles, James A ^a  

^a Unit #28 ^*  (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA;

ARTICLE; CHROMOSOME 2Q; FAMILIAL DISEASE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC MARKER; GENOTYPE; LUNG ARTERY PRESSURE; PRIORITY JOURNAL; PULMONARY HYPERTENSION;

EID: 0034021107     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.3.9906051     Document Type: Article

References (24)

1. Morse, J. H., A. C. Jones, R. J. Barst, S. E. Hodge, K. C. Wilhelmsen, and T. G Nygaard. 1997. Mapping of familial primary pulmonary hypertension locus (PPH1) to chromosome 2q31-q32. Circulation 95:2603-2606.
2. Nichols, W. C., D. L. Koller, B. Slovis, T. Foroud, V. H. Terry, N. D. Arnold, D. R. Siemieniak, L. Wheeler, J. A. Phillips, J. H. Newman, P. M. Conneally, D. Ginsburg, and J. E. Loyd. 1997. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32. Nat. Genet. 15:277-280.
3. Knowles, J. A., A. J. Fyer, V. J. Vieland, M. M. Weissman, S. E. Hodge, G. A. Heiman, F. Haghighi, G. M. de Jesus, H. Rassnick, X. Preudhomme-Rivelli, T. Austin, J. Cunjak, S. Mick, L. D. Fine, K. A. Woodley, K. Das, W. Maier, P. B. Adams, N. B. Freimer, D. F. Klein, and T. C. Gilliam. 1998. Results of a genome-wide genetic screen for panic disorder. Am. J. Med. Genet. 81:139-147.
4. Aita, V. M., J. Liu, J. A. Knowles, J. D. Terwilliger, R. Baltazar, A. Grunn, J. E. Loth, K. Kanyas, B. Lerer, J. Endicott, Z. Wang, G. Penchaszadeh, T. C. Gilliam, and M. Baron. 1999. A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus. Am. J. Hum. Genet. 64:210-217.
5. Broman K. W., J. C. Murray, V. C. Sheffield, R. L. White, and J. L. Weber. 1998. Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am. J. Hum. Genet. 63:861-869.
6. Dib, C., S. Faure, C. Fizames, D. Samson, N. Drouot, A. Vignal, P. Millasseau, S. Marc, J. Hazan, E. Seboun, M. Lathrop, G. Gyapay, J. Morissette, and J. Weissenbach. 1996. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380:152-154.
7. Collins, A., J. Frezal, J. Teague, and N. E. Morton. 1996. A metric map of humans: 23,500 loci in 850 bands. Proc. Natl. Acad. Sci. U.S.A. 93: 14771-14775.
8. Stewart, E. A., K. B McKusick, A. Aggarwal, E. Bajorek, S. Brady, A. Chu, N. Fang, D. Hadley, M. Harris, S. Hussain, R. Lee, A. Maratukulam, K. O'Connor, S. Perkins, M. Piercy, F. Qin, T. Reif, C. Sanders, X. She, W. L. Sun, P. Tabar, S. Voyticky, S. Cowles, J. B. Fan, and D. R. Cox. 1997. An STS-based radiation hybrid map of the human genome. Genome Res. 7:422-433.
9. Walter, M. A., D. J. Spillett, P. Thomas, J. Weissenbach, and P. N. Goodfellow. 1994. A method for constructing radiation hybrid maps of whole genomes. Nat. Genet. 7:22-28.
10. Lathrop, G. M., J. M. Lalouel, C. Julier, and J. Ott. 1985. Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am. J. Hum. Genet. 37:482-498.
11. O'Connell, J. R., and D. E. Weeks. 1995. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance. Nat. Genet. 11:402-408.
12. Spielman, R. S., R. E. McGinnis, and W. J. Ewens. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52:506-516.
13. Terwilliger, J. D. 1995. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am. J. Hum. Genet. 56:777-787.
14. Hudson, T. J., L. D. Stein, S. S. Gerety, J. Ma, A. B. Castle, J. Silva, D. K. Slonim, R. Baptista, L. Kruglyak, and S. H. Xu. 1995. An STS-based map of the human genome. Science 270:1945-1954.
15. Deloukas, P., G. D. Schuler, G. Gyapay, E. M. Beasley, C. Soderlund, P. Rodriguez-Tome, L. Hui, T. C. Matise, K. B. McKusick, J. S. Beckmann, S. Bentolila, M. Bihoreau, B. B. Birren, J. Browne, A. Butler, A. B. Castle, N. Chiannilkulchai, C. Clee, P. J. Day, A. Dehejia, T. Dibling, N. Drouot, S. Duprat, C. Fizames, and D. R. Bentley. 1998. A physical map of 30,000 human genes. Science 282:744-746.
16. Lee, S. D., K. R. Shroyer, N. E. Markham, C. D. Cool, N. F. Voelkel, and R. M. Tuder. 1998. Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. J. Clin. Invest. 101:927-934.
17. Endo, C., M. Sagawa, M. Sato, Y. Chen, A. Sakurada, H. Aikawa, S. Takahashi, K. Usuda, Y. Saito, and S. Fujimura. 1998. Sequential loss of heterozygosity in the progression of squamous cell carcinoma of the lung. Br. J. Cancer 78:612-615.
18. Kohno, T., K. Morishita, H. Takano, D. N. Shapiro, and J. Yokota. 1994. Homozygous deletion at chromosome 2q33 in human small-cell lung carcinoma identified by arbitrarily primed PCR genomic fingerprinting. Oncogene 9:103-108.
19. Shiseki, M., T. Kohno, R. Nishikawa, Y. Sameshima, H. Mizoguchi, and J. Yokota. 1994. Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma. Cancer Res. 54:5643-5648.
20. Chumakov, I. M., P. Rigault, I. Le Gall, C. Bellanne-Chantelot, A. Billault, S. Guillou, P. Soularue, G. Guasconi, E. Poullier, and I. Gros. 1995. A YAC contig map of the human genome. Nature 377:175-297.
21. Barst, R. J., and J. E. Loyd. 1998. Genetics and immunogenetic aspects of primary pulmonary hypertension. Chest 114:231S-236S.
22. Rich, S. 1998. Clinical insights into the pathogenesis of primary pulmonary hypertension. Chest 114:237S-241S.
23. Fishman, A. P. 1998. Etiology and pathogenesis of primary pulmonary hypertension: a perspective. Chest 114:242S-247S.
24. Tuder, R. M., and N. F. Voelkel. 1998. Pulmonary hypertension and inflammation. J. Lab. Clin. Med. 132:16-24.