Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans

Circulation Research

Volumn 111, Issue 12, 2012, Pages 1551-1564

  De Jesus Perez, Vinicio A ^a   Yuan, Ke ^a   Orcholski, Mark E ^a   Sawada, Hirofumi ^a,b   Zhao, Mingming ^a   Li, Caiyun Grace ^a   Tojais, Nancy F ^a   Nickel, Nils ^a   Rajagopalan, Viswanathan ^a   Spiekerkoetter, Edda ^a   Wang, Lingli ^a   Dutta, Roop ^a   Bernstein, Daniel ^a   Rabinovitch, Marlene ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

adenomatous poliposis coli; angiogenesis; integrin signaling; pulmonary hypertension; Wnt signaling

Indexed keywords

ALPHA3 INTEGRIN; APC PROTEIN; BETA CATENIN; INTEGRIN LINKED KINASE; INTEGRIN LINKED KINASE 1; LAMININ; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ADENOMATOUS POLIPOSIS COLI; ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ADHESION; CELL ISOLATION; COLON POLYPOSIS; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FOCAL ADHESION; GENETIC SUSCEPTIBILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PULMONARY ARTERY; PULMONARY HYPERTENSION; SURVIVAL;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; APOPTOSIS; BETA CATENIN; CELL ADHESION; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INTEGRIN ALPHA3; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; RESPIRATORY MUCOSA;

EID: 84871568768     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.267849     Document Type: Article

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