Basal PIR expression in HeLa cells is driven by NRF2 via evolutionary conserved antioxidant response element

Molecular and Cellular Biochemistry

Volumn 389, Issue 1-2, 2014, Pages 99-111

  Brzóska, Kamil ^a   Stępkowski, Tomasz M ^a   Kruszewski, Marcin ^a,b  

^a INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

ARE; NF B; NFE2L2; NRF2; PIR; Pirin

Indexed keywords

CELL PROTEIN; DNA POLYMERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON BINDING PROTEIN; LUCIFERASE; PIRIN; PROTEIN BCL 3; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; EVOLUTIONARY DEVELOPMENTAL BIOLOGY; GENE EXPRESSION; HELA CELL; HUMAN; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; REVERSE TRANSCRIPTION; RNA ISOLATION; SIGNAL TRANSDUCTION; TATA BOX; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANTIOXIDANT RESPONSE ELEMENTS; CARRIER PROTEINS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

EID: 84896545860     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1931-0     Document Type: Article

References (34)

1. Pang H, Bartlam M, Zeng Q, Miyatake H, Hisano T, Miki K, Wong LL, Gao GF, Rao Z (2004) Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. J Biol Chem 279:1491-1498 (Pubitemid 38082678)
2. Licciulli S, Luise C, Zanardi A, Giorgetti L, Viale G, Lanfrancone L, Carbone R, Alcalay M (2010) Pirin delocalization in melanoma progression identified by high content immunodetection based approaches. BMC Cell Biol 11:5
3. Wendler WM, Kremmer E, Forster R, Winnacker EL (1997) Identification of pirin, a novel highly conserved nuclear protein. J Biol Chem 272:8482-8489 (Pubitemid 27147811)
4. Adams M, Jia Z (2005) Structural and biochemical analysis reveal pirins to possess quercetinase activity. J Biol Chem 280:28675-28682 (Pubitemid 41105768)
5. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (1999) The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene 18:3316-3323 (Pubitemid 29286977)
6. Liu F, Rehmani I, Esaki S, Fu R, Chen L, de Serrano V, Liu A (2013) Pirin is an iron-dependent redox regulator of NF-kappaB. Proc Natl Acad Sci USA 110:9722-9727
7. Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H (2010) A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nat Chem Biol 6:667-673
8. Licciulli S, Cambiaghi V, Scafetta G, Gruszka AM, Alcalay M (2010) Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Leukemia 24:429-437
9. Yoshikawa R, Yanagi H, Hashimoto-Tamaoki T, Morinaga T, Nakano Y, Noda M, Fujiwara Y, Okamura H, Yamamura T (2004) Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells. Oncol Rep 12:1287-1293
10. Hubner RH, Schwartz JD, De BP, Ferris B, Omberg L, Mezey JG, Hackett NR, Crystal RG (2009) Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking. Mol Med 15:203-219
11. Spira A, Beane J, Shah V, Liu G, Schembri F, Yang X, Palma J, Brody JS (2004) Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci USA 101:10143-10148 (Pubitemid 38891209)
12. Gelbman BD, Heguy A, O'Connor TP, Zabner J, Crystal RG (2007) Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. Respir Res 8:10
13. Brzóska K, Kruszewski M (2009) Impact of pirin protein expression level on NF-kappaB signaling pathway activation. AIP Conf Proc 1204:260-261
14. Lin YY, Kiihl S, Suhail Y, Liu SY, Chou YH, Kuang Z, Lu JY, Khor CN, Lin CL, Bader JS, Irizarry R, Boeke JD (2012) Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Nature 482:251-255
15. Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR, Bell DA (2012) Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Res 40:7416-7429
16. Bergman AC, Alaiya AA, Wendler W, Binetruy B, Shoshan M, Sakaguchi K, Bergman T, Kronenwett U, Auer G, Appella E, Jornvall H, Linder S (1999) Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts. Cell Mol Life Sci 55:467-471 (Pubitemid 29178885)
17. Brzoska K, Stepkowski TM, Kruszewski M (2011) Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice. Redox Rep 16:129-133
18. Furukawa M, Xiong Y (2005) BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 25:162-171 (Pubitemid 40039808)
19. Zor T, Selinger Z (1996) Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies. Anal Biochem 236:302-308 (Pubitemid 26136110)
20. Bryne JC, Valen E, Tang MH, Marstrand T, Winther O, Krogh A, Lenhard B, Sandelin A (2008) JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update. Nucleic Acids Res 36:D102-D106 (Pubitemid 351149704)
21. Sandelin A, Carninci P, Lenhard B, Ponjavic J, Hayashizaki Y, Hume DA (2007) Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nat Rev Genet 8:424-436 (Pubitemid 46789243)
22. Larsen F, Gundersen G, Lopez R, Prydz H (1992) CpG islands as gene markers in the human genome. Genomics 13:1095-1107
23. Ovcharenko I, Nobrega MA, Loots GG, Stubbs L (2004) ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Nucleic Acids Res 32:W280-W286 (Pubitemid 38997344)
24. Imhoff BR, Hansen JM (2010) Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation. Cell Biol Toxicol 26:541-551
25. Riethoven JJ (2010) Regulatory regions in DNA: promoters, enhancers, silencers, and insulators. Methods Mol Biol 674:33-42
26. Hayes JD, McMahon M (2009) NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 34:176-188
27. Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW (2010) When NRF2 talks, who's listening? Antioxid Redox Signal 13:1649-1663
28. Stȩpkowski TM, Kruszewski MK (2011) Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis. Free Radic Biol Med 50:1186-1195
29. Sriram N, Kalayarasan S, Sudhandiran G (2009) Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling. Pulm Pharmacol Ther 22:221-236
30. Liu YC, Hsieh CW, Wu CC, Wung BS (2007) Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. Life Sci 80:1420-1430
31. Pulkkinen KH, Yla-Herttuala S, Levonen AL (2011) Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells. Free Radic Biol Med 51:2124-2131
32. Yu M, Li H, Liu Q, Liu F, Tang L, Li C, Yuan Y, Zhan Y, Xu W, Li W, Chen H, Ge C, Wang J, Yang X (2011) Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell Signal 23:883-892
33. Li Y, Jaiswal AK (1992) Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element. J Biol Chem 267:15097-15104
34. Venugopal R, Jaiswal AK (1996) Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc Natl Acad Sci USA 93:14960-14965 (Pubitemid 26419078)