A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens

Acta Crystallographica Section D: Biological Crystallography

Volumn 71, Issue , 2015, Pages 1684-1698

  Koh, Cho Yeow ^a,b   Kallur Siddaramaiah, Latha ^a   Ranade, Ranae M ^a   Nguyen, Jasmine ^a   Jian, Tengyue ^a   Zhang, Zhongsheng ^a   Gillespie, J Robert ^a   Buckner, Frederick S ^a   Verlinde, Christophe L M J ^a   Fan, Erkang ^a   Hol, Wim G J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Fragment based crystallographic cocktail screening; Inhibitor of histidyl tRNA synthetase; Reactive fragment; Structure guided drug discovery; Trypanosomiasis

Indexed keywords

PROTOZOA; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

ENZYME INHIBITOR; HISTIDINE TRANSFER RNA LIGASE; MOLECULAR LIBRARY;

ANTAGONISTS AND INHIBITORS; BINDING SITE; CHAGAS DISEASE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR LIBRARY; MOLECULAR MODEL; PHARMACOLOGY; TRYPANOSOMA CRUZI;

BINDING SITES; CHAGAS DISEASE; DRUG DISCOVERY; ENZYME INHIBITORS; HISTIDINE-TRNA LIGASE; HUMANS; MODELS, MOLECULAR; SMALL MOLECULE LIBRARIES; TRYPANOSOMA CRUZI;

EID: 84938846989     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004715007683     Document Type: Article

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