Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection

Structure

Volumn 20, Issue 10, 2012, Pages 1681-1691

  Koh, Cho Yeow ^a   Kim, Jessica E ^a   Shibata, Sayaka ^a,b   Ranade, Ranae M ^b   Yu, Mingyan ^a,c   Liu, Jiyun ^a   Gillespie, J Robert ^b   Buckner, Frederick S ^b   Verlinde, Christophe L M J ^a   Fan, Erkang ^a   Hol, Wim G J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; ENZYME INHIBITOR; METHIONINE; METHIONINE TRANSFER RNA LIGASE; METHIONINE TRANSFER RNA LIGASE INHIBITOR; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

ADENOSINE MONOPHOSPHATE; AMINOQUINOLINES; ANTIMALARIALS; BENZIMIDAZOLES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; METHIONINE; METHIONINE-TRNA LIGASE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; SURFACE PROPERTIES; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84867386982     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.07.011     Document Type: Article

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