Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors

ACS Chemical Biology

Volumn 8, Issue 11, 2013, Pages 2501-2508

  Bauman, Joseph D ^a,b   Patel, Disha ^a,b   Baker, Steven F ^c   Vijayan, R S K ^b   Xiang, Amy ^d   Parhi, Ajit K ^b,d   Martínez Sobrido, Luis ^c   Lavoie, Edmond J ^b   Das, Kalyan ^a,b   Arnold, Eddy ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d TAXIS Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; ENDONUCLEASE INHIBITOR; ENZYME INHIBITOR; POLYMERASE ACIDIC PROTEIN N TERMINAL ENDONUCLEASE DOMAIN; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; CHELATING AGENT;

2009 H1N1 INFLUENZA; ANTIVIRAL ACTIVITY; ARTICLE; CHELATION; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; IC 50; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; BIOASSAY; CELL CULTURE; CHEMISTRY; ENZYMOLOGY; HUMAN; IC50; ORTHOMYXOVIRIDAE; X RAY CRYSTALLOGRAPHY;

ANTIVIRAL AGENTS; BIOLOGICAL ASSAY; CATALYTIC DOMAIN; CELLS, CULTURED; CHELATING AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENDONUCLEASES; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ORTHOMYXOVIRIDAE;

EID: 84885181482     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400400j     Document Type: Article

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