Structural Basis for the Recognition of Isoleucyl-Adenylate and an Antibiotic, Mupirocin, by Isoleucyl-tRNA Synthetase

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 47387-47393

  Nakama, Takashi ^a,b   Nureki, Osamu ^a,b,c   Yokoyama, Shigeyuki ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

^c RIKEN HARIMA INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; CRYSTAL STRUCTURE; ENZYMES; MUTAGENESIS; RNA; SYNTHESIS (CHEMICAL);

ENERGY INTERMEDIATE;

ANTIBIOTICS;

ADENOSINE PHOSPHATE; ANTIBIOTIC AGENT; ISOLEUCINE TRANSFER RNA LIGASE; ISOLEUCYL ADENYLATE; PSEUDOMONIC ACID; UNCLASSIFIED DRUG; AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; AMINO ACYL TRNA LIGASES; FATTY ACID; ISOLEUCINE; ISOLEUCINE TRNA LIGASE; NONANOIC ACID; PHOSPHATE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARCHAEBACTERIUM; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME STRUCTURE; EUBACTERIUM; INHIBITION KINETICS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR RECOGNITION; MUTAGEN TESTING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; THERMUS THERMOPHILUS; AMINO ACID SEQUENCE; CHEMICAL MODEL; CHEMISTRY; IC 50; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY;

ANIMALIA; ARCHAEA; BACTERIA (MICROORGANISMS); EUKARYOTA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEGIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; THERMUS; THERMUS THERMOPHILUS;

ADENOSINE MONOPHOSPHATE; AMINO ACID SEQUENCE; AMINO ACIDS; AMINO ACYL-TRNA LIGASES; ANTIBIOTICS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FATTY ACIDS; INHIBITORY CONCENTRATION 50; ISOLEUCINE; ISOLEUCINE-TRNA LIGASE; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUPIROCIN; MUTAGENESIS, SITE-DIRECTED; PHOSPHATES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS; SUPPORT, NON-U.S. GOV'T; THERMUS THERMOPHILUS;

EID: 0035861676     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M109089200     Document Type: Article

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