Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs

Journal of Molecular Biology

Volumn 397, Issue 2, 2010, Pages 481-494

  Merritt, Ethan A ^a   Arakaki, Tracy L ^a   Gillespie, J Robert ^b   Larson, Eric T ^a   Kelley, Angela ^b   Mueller, Natascha ^b   Napuli, Alberto J ^b   Kim, Jessica ^a   Zhang, Li ^a   Verlinde, Christophe L M J ^a   Fan, Erkang ^a   Zucker, Frank ^a   Buckner, Frederick S ^b   Van Voorhis, Wesley C ^b   Hol, Wim G J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

aminoacyl tRNA synthetase; drug target; protozoa; RNAi; tropical disease

Indexed keywords

HISTIDINE TRANSFER RNA LIGASE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; EUKARYOTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROKARYOTE; SPECIES DIFFERENCE; STRUCTURAL HOMOLOGY; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

BACTERIA (MICROORGANISMS); EUKARYOTA; PROKARYOTA; PROTOZOA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 77349101493     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.01.051     Document Type: Article

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