Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design

Journal of Medicinal Chemistry

Volumn 56, Issue 4, 2013, Pages 1748-1760

  Teng, Min ^a   Hilgers, Mark T ^a   Cunningham, Mark L ^a   Borchardt, Allen ^a   Locke, Jeffrey B ^a   Abraham, Sunny ^a   Haley, Gregory ^a   Kwan, Bryan P ^a   Hall, Courtney ^a   Hough, Grayson W ^a   Shaw, Karen J ^a   Finn, John ^a  

^a Trius Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 HYDROXY N [(4 PHENOXYPHENYL)SULFONYL]BUTANAMIDE; 2 AMINO N [[3 (1 AMINO 3 CHLOROISOQUINOLIN 6 YL)PHENYL]SULFONYL] 3 HYDROXYBUTANAMIDE; 2 AMINO N [[3 (1 AMINOISOQUINOLIN 6 YL)PHENYL]SULFONYL] 3 HYDROXYBUTANAMIDE; 2 AMINO N [[3 (2,4 DIAMINOQUINAZOLIN 7 YL)PHENYL]SULFONYL] 3 HYDROXYBUTANAMIDE; 2 AMINO N [[3 (4 AMINO 2 CHLOROQUINAZOLIN 7 YL)PHENYL]SULFONYL] 3 HYDROXYBUTANAMIDE; 2 AMINO N [[3 (4 AMINO 2 METHYLQUINAZOLIN 7 YL)PHENYL]SULFONYL] 3 HYDROXYBUTANAMIDE; 2 AMINO N [[7 (6 AMINOPYRIMIDIN 4 YL)NAPHTHALEN 2 YL]SULFONYL] 3 HYDROXYBUTANAMIDE; ANTIINFECTIVE AGENT; LIGASE INHIBITOR; TERT BUTYL [1 (3 BROMOBENZENESULFONAMIDO) 3 (TERTBUTOXY) 1 OXOBUTAN 2 YL]CARBAMATE; TERT BUTYL [1 (7 BROMONAPHTHALENE 2 SULFONAMIDO) 3 (TERTBUTOXY) 1 OXOBUTAN 2 YL]CARBAMATE; TERT BUTYL [3 (TERT BUTOXY) 1 OXO 1 [7 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)NAPHTHALENE 2 SULFONAMIDO]BUTAN 2 YL]CARBAMATE; THREONINE TRANSFER RNA LIGASE; THREONINE TRANSFER RNA LIGASE INHIBITOR; UNCLASSIFIED DRUG; [2 AMINE N [[ 3 (4 AMINOQUINAZOLIN 7 YL)PHENYL]SULFONYL] 3 HYDROXYBUTANAMIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; BURKHOLDERIA THAILANDENSIS; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HUMAN; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 84874602301     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301756m     Document Type: Article

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