TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

Experimental Neurology

Volumn 273, Issue , 2015, Pages 24-35

  Zhao, Weihua ^a   Beers, David R ^a   Bell, Shaughn ^b   Wang, Jinghong ^a   Wen, Shixiang ^a   Baloh, Robert H ^b   Appel, Stanley H ^a  

^a HOUSTON METHODIST HOSPITAL   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

CD14; Microglia; NF B; NLRP3 inflammasome; TDP 43

Indexed keywords

CD14 ANTIGEN; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TAR DNA BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; ANTIBODY; CARRIER PROTEIN; CYBB PROTEIN, MOUSE; DNA BINDING PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; NLRP3 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RETINOID; SR 11302;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EMBRYO; EXTRACELLULAR SPACE; MOTONEURON; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; MAMMALIAN EMBRYO; METABOLISM; MICROGLIA; MUTATION; NEWBORN; SPINAL CORD;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES; ANTIGENS, CD14; CARRIER PROTEINS; CASPASE 1; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; INTERLEUKIN-1BETA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROGLIA; MOTOR NEURONS; MUTATION; NADPH OXIDASE; NF-KAPPA B; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RETINOIDS; RNA, MESSENGER; SPINAL CORD; TRANSFECTION;

EID: 84938828009     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2015.07.019     Document Type: Article

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