Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury

Journal of Neuroscience

Volumn 34, Issue 14, 2014, Pages 4822-4836

  Bartus, Katalin ^a   James, Nicholas D ^a   Didangelos, Athanasios ^a   Bosch, Karen D ^a   Verhaagen, Joost ^b   Yáñez Muñoz, Rafael J ^c   Rogers, John H ^d   Schneider, Bernard L ^e   Muir, Elizabeth M ^d   Bradbury, Elizabeth J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e EPFL   (Switzerland)

Author keywords

Chondroitinase; Contusion; Gene therapy; Neuroprotection; Spinal cord injury

Indexed keywords

CD206 ANTIGEN; CD68 ANTIGEN; CHONDROITIN ABC LYASE; LENTIVIRUS VECTOR; LYMPHOCYTE ANTIGEN; PROTEOCHONDROITIN SULFATE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ELECTROPHORESIS; EXPERIMENTAL BEHAVIORAL TEST; EXPERIMENTAL SPINAL CORD CONTUSION; EXPERIMENTAL SPINAL CORD INJURY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INNERVATION; MACROPHAGE; MALE; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SENSORIMOTOR FUNCTION; SEROTONINERGIC NERVE CELL; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

CHONDROITINASE; CONTUSION; GENE THERAPY; NEUROPROTECTION; SPINAL CORD INJURY;

ANIMALS; CELLS, CULTURED; CHONDROITIN ABC LYASE; CHONDROITIN SULFATE PROTEOGLYCANS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; FEMALE; GENE EXPRESSION REGULATION; GENETIC THERAPY; INJECTIONS, SPINAL; MACROPHAGES; NERVE TISSUE PROTEINS; NEURAL CONDUCTION; PSYCHOMOTOR PERFORMANCE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TIME FACTORS;

EID: 84899446231     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4369-13.2014     Document Type: Article

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