AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury

Journal of Neuroscience

Volumn 34, Issue 30, 2014, Pages 9951-9962

  Lewandowski, Gail ^a   Steward, Oswald ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biomaterials; Combination therapy; PTEN; Regeneration; Spinal cord injury

Indexed keywords

COMPLEMENTARY DNA; FIBRIN; IMMUNOGLOBULIN G ANTIBODY; NEURON SPECIFIC NUCLEAR PROTEIN; PARVOVIRUS VECTOR; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN S6; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL SIGNALING ASSAY; CERVICAL SPINAL CORD INJURY; CONTROLLED STUDY; FEMALE; FUNCTIONAL ELECTRICAL STIMULATION; FUNCTIONAL TRAINING; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; MOTOR PERFORMANCE; MRNA EXPRESSION ASSAY; NERVE FIBER REGENERATION; NEUROANATOMICAL TRACT TRACING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SALMON; SENSORIMOTOR CORTEX; VOLUNTARY MOVEMENT;

BIOMATERIALS; COMBINATION THERAPY; PTEN; REGENERATION; SPINAL CORD INJURY;

AGE FACTORS; ANIMALS; AXONS; CERVICAL VERTEBRAE; DEPENDOVIRUS; FEMALE; FIBRIN; INJECTIONS, INTRAVENTRICULAR; NERVE REGENERATION; PTEN PHOSPHOHYDROLASE; PYRAMIDAL TRACTS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; RNA, SMALL INTERFERING; SALMON; SPINAL CORD INJURIES;

EID: 84904568163     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1996-14.2014     Document Type: Article

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